The Sepsis Tightrope: Tracking Antibiotic Levels to Hit the Sweet Spot in the ICU
This prospective, observational study examined the beta-lactam antibiotic concentrations in the crucial first 48 hours of treatment for patients with community-acquired sepsis in the Intensive Care Unit (ICU). The study... read more
Brain Imaging Reveals Hidden Awareness in Critically Ill ICU Patients
This study investigated covert awareness—preserved consciousness without observable behavioral signs—in critically ill patients with acute brain injuries in the Intensive Care Unit (ICU). Researchers used functional... read more
Predicting Transfusion Risks to Power Safer Blood Management
This systematic review analyzed the use of Artificial Intelligence (AI) models over the past decade in identifying and predicting Adverse Transfusion Reactions (ATRs) and their implications for clinical management. The... read more
Bedside Procedures in the ICU
This handbook is a guide to best practice in interventions commonly encountered in the ICU. It is clinically orientated providing step-by-step explanations and illustrations of most invasive procedures, check lists to make... read more
The Hidden Danger of Insufficient Sedation in ARDS
This prospective observational study highlights a critical issue in the Intensive Care Unit (ICU): a substantial number of patients with Acute Respiratory Distress Syndrome (ARDS) receiving continuous neuromuscular blockade... read more
Hemodynamics: The Key to Noninvasive Ventilation (NIV) Success
This large multicenter observational study found that hemodynamic instability—defined as needing vasopressor support within 24 hours of starting NIV—was linked to a significantly higher risk of NIV failure. The crucial... read more
VIS to Win: Predicting Mortality After Infective Endocarditis Surgery
This study explored the predictive power of the Vasoactive-Inotropic Score (VIS) in patients who underwent valve replacement surgery for infective endocarditis (IE). The key finding is that the VIS is a strong and superior... read more
AI Alert: Machine Learning Predicts Septic Shock Early in the ICU
This study developed and successfully validated a machine learning (ML) model designed to provide an early prediction of septic shock in intensive care unit (ICU) patients diagnosed with sepsis. Best Performer: Out of... read more
AI Reinforcement Learning Slashes Kidney Injury Risk After Surgery
This study explored the use of Reinforcement Learning (RL)-a type of artificial intelligence—to personalize hemodynamic management (managing blood flow and pressure) in the intensive care unit (ICU) immediately following... read more
Better Kidney Score: 6-Hour Urine Test Outperforms Standard Measures for ICU Mortality
This prospective, single-center observational study investigated whether using 6-hour urine creatinine clearance (CrCl) could serve as a more effective measure for the kidney component of the SOFA score in ICU patients. Key... read more
Basics of Mechanical Ventilation
This book is a practical and easily understandable guide for mechanical ventilation. With a focus on the basics, this text begins with a detailed account of the mechanisms of spontaneous breathing as a reference point to... read more
Nomogram Predicts Mortality Risk for Sepsis Brain Injury
This retrospective cohort study developed and validated a nomogram—a graphic calculating tool—to predict ICU mortality in patients with Sepsis-Associated Encephalopathy (SAE), a serious complication where sepsis affects... read more
No Survival Edge for LUCAS Device in Obese Cardiac Arrest Patients
This retrospective cohort study compared LUCAS®-assisted mechanical CPR with high-quality manual chest compressions in overweight and obese patients experiencing in-hospital cardiac arrest (IHCA). Summary of Findings: No... read more
Intra-Abdominal Hypertension – Core Critical Care
The most popular book at ISICEM meeting. Despite increasing interest in intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as causes of significant morbidity and mortality among the critically ill,... read more
Beyond the Diaphragm: Combined Muscle Ultrasound Predicts Extubation Success in Sepsis
This prospective observational study investigated a novel approach using combined ultrasound measurements of both the diaphragm and intercostal muscles to better predict extubation outcomes in mechanically ventilated patients... read more
Basic Ultrasound Skills “Head to Toe” for General Intensivists (Lessons from the ICU)
The aim of this book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, is to educate and train practitioners in the safe and competent use of diagnostic ultrasound imaging in the visualization... read more
Most ICU Infections Miss the Mark for Classic Fever
The large number of patients being treated for infection without a high fever suggests that many could be ideal candidates for a clinical trial investigating induced hyperthermia (purposely raising body temperature) as a... read more
Remimazolam Triumphs Over Propofol for Safer ICU Sedation During Bronchoscopy
This randomized controlled trial compared remimazolam to propofol for moderate sedation during fiberoptic bronchoscopy (FB) in critically ill patients in the Surgical Intensive Care Unit (SICU) who had pre-existing liver... read more
Sepsis Danger: High Ferritin Levels Flag Risk of Acute Liver Injury
This study used data from the MIMIC-IV database (training group) and an external hospital dataset (clinical validation group) to develop and validate a prediction model for sepsis-associated acute liver injury (SALI). The... read more
Melatonin for Delirium Prevention: The Sleep Hormone Doesn’t Pass the ICU Test
Despite its frequent occurrence and association with increased mortality in critically ill patients, delirium prevention remains challenging. A recent meta-analysis sought to resolve conflicting results from randomized controlled... read more
ICU Risk Check: Simple Blood Biomarker Predicts Mortality in Heart Attack Patients
A study using data from the MIMIC-IV database investigated the prognostic value of the Neutrophil-Platelet Activity Ratio (NPAR) in critically ill adult patients admitted to the ICU with a first acute myocardial infarction... read more
A Shift in Strategy: Rethinking Blood Transfusions for Brain Injury
Recent clinical trials have challenged the standard practice of using a restrictive Red Blood Cell (RBC) transfusion strategy for critically ill brain-injured patients (ABI). Restrictive Approach is Questioned: The prevailing... read more
