Massive Alveolar Hemorrhage Presenting During the COVID-19 Pandemic
The coronavirus disease (COVID-19) pandemic has challenged healthcare systems and has resulted in complex diagnostic processes for patients with non-COVID-19 pathology. Here, we demonstrate a case of massive alveolar... read more
90 Day Outcomes of COVID-19 Patients in European ICUs
This communication delineates outcomes in COVID-19 patients in the context of ARDS severity, ventilatory management, and variables associated with mortality on a 90-day follow-up for subgroups of patients after ICU admission.... read more
Pharmacokinetic-Pharmacodynamic Modeling and Simulation
This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized... read more
Sedation with Midazolam After Cardiac Surgery in Children with and without Down Syndrome
The majority of children with and without Down syndrome required additional sedation after cardiac surgery. This pharmacokinetic and pharmacodynamic analysis does not provide evidence for different dosing of midazolam in... read more
Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual... read more
Effect of Infusion Set Replacement Intervals on Catheter-related Bloodstream Infections
The optimal duration of infusion set use to prevent life-threatening catheter-related bloodstream infection (CRBSI) is unclear. We aimed to compare the effectiveness and costs of 7-day (intervention) versus 4-day (control)... read more
The Blood-Clot Problem Is Multiplying
For weeks, Americans looked on as other countries grappled with case reports of rare, sometimes fatal blood abnormalities among those who had received the AstraZeneca vaccine against COVID-19. That vaccine has not yet... read more
Co-infection in Critically Ill Patients with COVID-19
During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness and death was complicated by bacterial co-infection,... read more
Patient’s Clinical Presentation and CPPopt Availability: Any Association?
In this retrospective multicenter study, none of the selected admission and treatment variables were related to the CPPopt yield. The median CPPopt yield was 80.7% (interquartile range 70.9–87.4%). None of the selected... read more
ACEP Task Force on Septic Shock Should Replace the Surviving Sepsis Campaign
The critical care community has long been plagued by a series of antiquated, overbearing guidelines created by the Surviving Sepsis Campaign (SSC). The campaign was originally sponsored by Eli Lilly and Edwards Life Sciences,... read more
Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities
Targeted temperature management at 33–34°C was associated with a significantly higher rate of a good neurologic outcome in the moderate-severity postcardiac arrest syndrome group, but not in the low- or high-severity group. A... read more
Mortality Outcomes with Hydroxychloroquine and Chloroquine in COVID-19 Patients
Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate... read more
Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target?
Our results suggest that patients with septic shock and chronic hypertension treated with angiotensin II receptor blocker may benefit from a high mean arterial pressure target to reduce the risk of acute kidney injury occurrence. We... read more
Ketamine: A Review of an Established Yet Often Underappreciated Medication
has proven to be a complex medication with unusual properties, heterogeneous, interconnected mechanisms, and diverse, sometimes contested, clinical uses. Ketamine's story begins in 1956 when scientists identified a new... read more
Outcomes of Patients with COVID-19 and Relationship with Lung Ultrasound Signs
In patients with COVID-19 pneumonia, Lung Ultrasound Signs (LUS) signs, including the aeration score, were related to respiratory and systemic symptoms 1 month after ultrasound screening examination. In these patients, a... read more
Understanding The Links Between COVID-19 Vaccines and Thrombosis
The Advisory Committee on Immunization Practices (ACIP) is convening an emergency meeting to discuss adverse events that recently led to thrombotic events in 6 women administered the Johnson & Johnson COVID-19 vaccine in... read more
Sunlight Linked to Lower COVID-19 Deaths
Our analysis suggests that higher ambient UVA exposure is associated with lower COVID‐19 specific mortality. Further research on the mechanism may indicate novel treatments. Optimised UVA exposure may have population health... read more
Peripheral Arteriovenous Malformations: Classification and Endovascular Treatment
In this review we cover the classification and endovascular management of arteriovenous malformations (AVMs). We begin by viewing AVMs in relation to the broader class of congenital vascular malformations and subsequently... read more
Use of Biomarkers to Identify AKI to Help Detect Sepsis in Patients with Infection
Use of the urinary (tissue inhibitor of metalloproteinases-2) × (insulin-like growth factor binding protein 7) test could identify acute kidney injury in patients with infection, possibly helping to detect sepsis, nearly... read more
Trauma: My Life as an Emergency Surgeon
TRAUMA is Dr. Cole's harrowing account of his life spent in the ER and on the battlegrounds, fighting to save lives. In addition to his gripping stories of treating victims of gunshot wounds, stabbings, attempted suicides,... read more
Individualized vs. Fixed Positive End-expiratory Pressure for Intraoperative Mechanical Ventilation in Obese Patients
This secondary analysis of obese patients undergoing laparoscopic surgery found better oxygenation, lower driving pressures, and redistribution of ventilation toward dependent lung areas measured by electrical impedance tomography... read more
Operative Techniques and Recent Advances in Acute Care and Emergency Surgery
The aim of this book is to identify and shed new light on the main surgical practices involved in acute care and trauma surgery. Adopting an evidence-based approach, a multidisciplinary team of surgeons and intensivists... read more
