Tag: analysis
Evidence-Based Critical Care
This is the premier evidence-based textbook in critical care medicine. The Third Edition features updated and revised chapters, numerous new references, streamlined content, and new chapters on key topics such as the new... read more
Predicting Deterioration of Sepsis Patients Using Continuous HVR Analysis
We showed that continuous electrocardiograms (ECG) recordings can be automatically analyzed and used to extract heart rate variability (HRV) features associated with clinical deterioration in sepsis. The predictive accuracy... read more
Loved Ones Are Not “Visitors” in a Patient’s Life
Hospitals are institutions whose primary task is to treat patients. Family-centered care, which considers loved ones as equal partners in patient care, has been gaining recognition in the adult care setting. Our aim was... read more
Trauma Group Publishes Action Plan, Makes Data Available for Secondary Analyses
The American College of Surgeons (ACS) has long advocated for the creation of a US National Trauma System to improve quality of care, decrease inequities, and save lives as one of its top legislative priorities, part of which... read more
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest
Targeting a mean arterial blood pressure of 77 mm Hg or 63 mm Hg in patients who had been resuscitated from cardiac arrest did not result in significantly different percentages of patients dying or having severe disability... read more
Bougie vs. Endotracheal Tube with Stylet on Successful Intubation
Among critically ill adults undergoing tracheal intubation, use of a bougie did not significantly increase the incidence of successful intubation on the first attempt compared with use of an endotracheal tube with stylet. Among... read more
Optimizing the Design and Analysis of Future AKI Trials
Acute kidney injury (AKI) is a complex clinical syndrome associated with an increased risk of morbidity and mortality, particularly in critically ill and perioperative patient populations. Most AKI clinical trials have... read more
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19
Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. The... read more
Multi-Organ Point-Of-Care Ultrasound in AKI
Acute kidney injury (AKI) is a clinical syndrome caused by a multitude of hemodynamic, toxic, and structural insults to the kidney, and portends worse patient outcomes. Despite careful history taking, physical examination,... read more
Sotrovimab Effect Among High-risk COVID-19 Patients
Among nonhospitalized patients with mild to moderate COVID-19 and at risk of disease progression, a single intravenous dose of sotrovimab, compared with placebo, significantly reduced the risk of a composite end point of... read more
Processed Electroencephalography-guided General Anaesthesia to Reduce Postoperative Delirium
Our primary analysis demonstrated a highly sensitive result with a pooled analysis of trials in which the intervention group adhered to manufacturer's recommended guidelines showing reduced incidence of postoperative delirium... read more
Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC)
Enteral melatonin initiated within 48 h of ICU admission did not reduce the prevalence of delirium compared to placebo. These findings do not support the routine early use of melatonin in the critically ill. A total of... read more
Physiologically Difficult Airway Evaluation
Multiple international airway societies have created guidelines for the management of the difficult airway. In critically ill patients, there are physiologic derangements beyond inadequate airway protection or hypoxemia.... read more
Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis
The incidence of postoperative atelectasis was lower in patients undergoing either laparoscopic colectomy or robot-assisted prostatectomy who received pressure support ventilation during emergence from general anesthesia... read more
Anti-interleukin Drugs Effect on COVID-19 Patients
Drugs targeting IL-1 or IL-6 did not shorten the time to clinical improvement in this sample of patients with COVID-19, hypoxic respiratory failure, low SOFA score, and low baseline mortality risk. Between April 4, and... read more
Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest
Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation. However, there is uncertainty... read more
Neurological Complications Acquired During Pediatric Critical Illness
Graphical models that include biomarkers in addition to clinical data are promising methods to evaluate direct relationships in the development of neurologic complications in critically ill children. Future work is required... read more
