Acute Respiratory Failure in COVID-19: Typical ARDS?

Acute Respiratory Failure in COVID-19: Typical ARDS?

COVID-19 is highly infectious and can lead to fatal comorbidities especially ARDS. There are currently no recommended specific anti-COVID-19 treatments, so supportive treatment is important. Fully understanding the characteristics... read more

COVID-19 Patients with Respiratory Failure: What Can We Learn From Aviation Medicine?

COVID-19 Patients with Respiratory Failure: What Can We Learn From Aviation Medicine?

Patients with COVID-19 may present to hospitals and emergency medical services with an atypical form of acute respiratory distress syndrome (ARDS). Although anecdotal, a common clinical pattern has emerged, with a remarkable... read more

Severe Influenza in Critically Ill Patients

Severe Influenza in Critically Ill Patients

The present review summarizes current knowledge on pathogenesis and clinical manifestations of severe influenza. Immunological dysfunction during viral infection correlates with severity and mortality among ICU patients.... read more

High-Flow Nasal Cannula vs. Noninvasive Ventilation

High-Flow Nasal Cannula vs. Noninvasive Ventilation

High-flow conditioned oxygen therapy delivered through nasal cannulae and noninvasive mechanical ventilation (NIV) may reduce the need for reintubation. Therefore, Hernández et al set out to test if high-flow conditioned... read more

Effect of Vitamin C Infusion on Organ Failure in Patients With Sepsis and ARDS

Effect of Vitamin C Infusion on Organ Failure in Patients With Sepsis and ARDS

In this preliminary study of patients with sepsis and Acute Respiratory Distress Syndrome (ARDS), a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers... read more

Early Mobilization Reduces Duration of Mechanical Ventilation and Intensive Care Unit Stay in Patients With ARF

Early Mobilization Reduces Duration of Mechanical Ventilation and Intensive Care Unit Stay in Patients With ARF

The introduction of early mobilization for patients with mechanical ventilation (MV) in the ICU shortened MV durations and ICU stays. A multidisciplinary team that includes the patient's family can work together to improve... read more

Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care

Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care

Randomized clinical trials (RCTs) are conducted to guide clinicians' selection of therapies for individual patients. Currently, RCTs in critical care often report an overall mean effect and selected individual subgroups.... read more

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults

Lower respiratory tract infections (LRTIs) are the leading cause of infectious disease-related deaths worldwide yet remain challenging to diagnose because of limitations in existing microbiologic tests. In critically ill... read more

Noninvasive Ventilation Through the Helmet Can Be Used For Early Mild and Moderate ARDS

Noninvasive Ventilation Through the Helmet Can Be Used For Early Mild and Moderate ARDS

Debating data have been published as regards the beneficial or deleterious effect of spontaneous breathing (SB) in comparison to controlled mechanical ventilation (CMV) during acute respiratory failure. Spontaneous breathing... read more

Midazolam Dose Optimization in Critically Ill Pediatric Patients with ARF

Midazolam Dose Optimization in Critically Ill Pediatric Patients with ARF

This work leveraged available knowledge on non-heritable and heritable factors affecting midazolam pharmacokinetic in pediatric subjects with primary respiratory failure requiring mechanical ventilation, providing the basis... read more

Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With ARF

Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With ARF

Among critically ill immunocompromised patients with acute respiratory failure (ARF), high-flow oxygen therapy did not significantly decrease day-28 mortality compared with standard oxygen therapy. Of 778 randomized patients... read more

Optimizing Respiratory Management in Resource-limited Settings

Optimizing Respiratory Management in Resource-limited Settings

This review focuses on the emerging body of literature regarding the management of acute respiratory failure (ARF) in low- and middle-income countries (LMICs). The aim is to abstract management principles that are of relevance... read more

Optimizing Ceftolozane-tazobactam Dosage in Critically Ill Patients During Continuous Venovenous Hemodiafiltration

Optimizing Ceftolozane-tazobactam Dosage in Critically Ill Patients During Continuous Venovenous Hemodiafiltration

Ceftolozane-tazobactam (C/T), the combination of a new cephalosporin with a classic β-lactamase inhibitor, is currently considered the most active betalactam antibiotic against P. aeruginosa. Despite several case reports... read more

A Prospective Investigation of Interleukin-8 Levels in Pediatric ARF and ARDS

A Prospective Investigation of Interleukin-8 Levels in Pediatric ARF and ARDS

The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure (ARF) at risk for PARDS has not been examined.... read more