Tag: biomarkers
Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations
In uncontrolled, moderate-to-severe asthma, higher baseline FeNO levels were associated with greater risk of severe asthma exacerbations, particularly in combination with elevated eosinophil count and prior exacerbations,... read more
Diagnostic accuracy of prehospital serum S100B and GFAP in patients with mild TBI
Early prehospital and in-hospital S100B levels 0.10 μg/L was 100% (95%CI: 89.1;100.0) in prehospital samples and 100% (95% CI 89.1;100.0) in in-hospital samples. The specificity was 15.4% (95%CI: 12.4;18.7) in prehospital... read more
Neurological Complications Acquired During Pediatric Critical Illness
Graphical models that include biomarkers in addition to clinical data are promising methods to evaluate direct relationships in the development of neurologic complications in critically ill children. Future work is required... read more
Cardiac Markers Implication in Risk-stratification and Management for COVID-19 Patients
COVID-19 patients with pre-existing coronary artery disease represented a higher abnormal percentage of cardiac markers, accompanied by high mortality and ICU admission rate. BNP together with hs-TNI, α- HBDH, CK-MB and... read more
Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients
These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute... read more
Use of Biomarkers to Identify AKI to Help Detect Sepsis in Patients with Infection
Use of the urinary (tissue inhibitor of metalloproteinases-2) × (insulin-like growth factor binding protein 7) test could identify acute kidney injury in patients with infection, possibly helping to detect sepsis, nearly... read more
Biomarkers of Kidney Disease
Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection,... read more
Enhancing anti-tumour efficacy with immunotherapy combinations
Several tumour types are responsive to immunotherapy, as shown by regulatory approvals for immune checkpoint inhibitors. However, many patients either do not respond or do not have durable clinical benefit. Thus, there... read more
Prediction Model for Severe CAP among Patients with Diabetes Mellitus
Diabetes is an independent risk factor for the development of severe community-acquired pneumonia (CAP) and associated with pneumonia-related hospitalization as well as mortality. Here, we assessed several selected biomarkers... read more
Serum Amylase and Lipase for the Prediction of Pancreatic Injury in Critically Ill Children Admitted to the PICU
Serum amylase and lipase could serve as independent biomarkers to predict pancreatic injury in critically ill children. A group of 79 children who died of different causes were investigated by autopsy. They were divided... read more
Time-Controlled Adaptive Ventilation Versus Volume-Controlled Ventilation in Experimental Pneumonia
In the model of pneumonia used herein, at the same tidal volume and mean airway pressure, time-controlled adaptive ventilation, compared with volume-controlled ventilation, was associated with less lung damage and bacteremia... read more
Lipid Mediators in Critically Ill Patients: A Step Towards Precision Medicine
In this review, we provide an overview of the role of fatty acid-derived lipid mediators as endogenous regulators of the inflammatory, anti-inflammatory and pro-resolving response and future directions for use of clinical... read more
Increased Dead Space Ventilation and Refractory Hypercapnia in Patients with COVID-19
We speculate that thromboinflammation with pulmonary microvasculature occlusion leads to a sudden increase in dead space and shunt resulting in severe hypercapnia and hypoxemia in coronavirus disease 2019 patients. Early... read more
Cancer Biomarker Measurement using a Smartphone
Canadian researchers create technology that reads cancer biomarker like a blood-sugar monitor. Researchers at the Canadian McMaster and Brock universities have created the prototype for a smartphone device to measure a biomarker... read more
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS
In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more
Biomarkers of Sepsis: Time for a Reappraisal
The precise roles of most biomarkers in the management of septic patients have not been well defined, and of the many biomarkers that have been studied, only a few have been evaluated in large or repeated studies. As... read more
Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients
Humanigen, the clinical stage biopharmaceutical company focused on preventing and treating cytokine storm, has reported positive data from the first clinical use of lenzilumab, its humaneered anti-human granulocyte macrophage-colony... read more
