Tag: bleeding
CAR-T Therapy – Critical Care Considerations of Chimeric Antigen Receptor
Despite significantly improving the treatment of blood cancers, CAR T-cell therapy still faces significant hurdles due to its complex and varied toxicities, which require ongoing research to optimize management; while understanding... read more
Factors Associated with Delayed Extubation in Post Cardiac Surgery Patients
The process of extubation is a crucial phase in postoperative care. By comprehending the elements that impact DE, healthcare providers can effectively allocate medical resources to enhance the success of weaning, extubation,... read more
Anticoagulation Among COVID-19 Patients
In this prospectively designed meta-analysis of randomized trials, administration of therapeutic- compared with prophylactic-dose anticoagulation with heparins to patients hospitalized for COVID-19 was associated with 23%... read more
Sepsis Patients with Disseminated Intravascular Coagulation
Sepsis is a life-threatening organ dysfunction caused by dysregulation of the body's response to infection, and is one of the leading causes of death in intensive care units. In sepsis, the systemic inflammatory reaction... read more
Platelet Transfusions: Ten Things ICU Specialists Need to Know
Thrombocytopenia is common in critically ill patients and is associated with higher bleeding risk and worse outcomes. Platelet transfusions are frequently used to prevent or treat bleeding, though often with uncertain... read more
Non-invasive vs. Arterial Pressure Monitoring in the Pre-hospital Critical Care Environment
Non-invasive blood pressure measurements are often inaccurate within the pre-hospital critical care setting, particularly in patients with hemodynamic instability which are the group in which the accuracy of vital signs is... read more
Traumatic Major Hemorrhage in a Tertiary Trauma Center
Major traumatic hemorrhage is potentially preventable with rapid hemorrhage control and improved resuscitation techniques. The time from injury to hospital, resuscitation, diagnosis, and definitive bleeding control should... read more
Platelets and Fibrinogen Matter When Bleeding on ECMO
Fibrinolysis is poorly investigated in ECMO patients, partly due to a lack of routine laboratory tests evaluating fibrinolysis. Hence, hyperfibrinolysis may be a contributor to bleeding risk during ECMO treatment. However,... read more
ECPR in 2023
Extracorporeal cardiopulmonary resuscitation (ECPR) is invasive and resource intense. Data suggesting a survival benefit in patients after OHCA and ECPR derive from retrospective registries and meta-analyses. In order to... read more
Hyperlipidemia in Immune Thrombocytopenia
A high proportion of ITP patients suffered from metabolic disorders, especially hyperlipidemia. Patients with hyperlipidemia may have more severe bleeding symptoms and worse responses to ITP treatments. Statin may help... read more
Revisiting VA-ECMO in Infarct-related Cardiogenic Shock
Despite advances in medical therapies and coronary revascularization, infarct-related cardiogenic shock remains a life-threatening emergency with high death rates. Temporary mechanical circulatory support, including peripheral... read more
ECLS in Infarct-Related Cardiogenic Shock
In patients with acute myocardial infarction complicated by cardiogenic shock with planned early revascularization, the risk of death from any cause at the 30-day follow-up was not lower among the patients who received ECLS... read more
Anticoagulation in the ICU: Contact Pathway Inhibition Future
Bleeding and thrombotic complications are the main cause of morbidity and mortality in critically ill patients on the intensive care unit (ICU), receiving short-term percutaneous mechanical circulatory support (pMCS) by extracorporeal... read more
TXA Should be Urgently and Broadly Adopted for Brain Bleeds
Everything looked better with tranexamic acid (TXA), and none of it was statistically significant. True, in a subgroup analysis of patients who actually had a head bleed on imaging—which, gee whiz, seems like an important... read more
Prostacyclin Anticoagulation Efficacy in Critically Ill Patients Requiring Extracorporeal Support
Extracorporeal support modalities are highly prothrombotic. Anticoagulation is frequently used for patients receiving Continuous Renal Replacement Therapy (CRRT), Molecular Adsorbent Recirculating System (MARS), and Extracorporeal... read more
Disseminated Intravascular Coagulation in COVID-19 Setting
Disseminated intravascular coagulation (DIC) is an acquired syndrome that can lead to catastrophic thrombosis and hemorrhage. In DIC, an uncontrolled release of pro-inflammatory mediators activates tissue factor-dependent... read more
Thrombotic and Bleeding Complications During Antithrombotic Treatment
Remarkable progress has been made in the pharmacological management of patients with cardiovascular disease, including the frequent use of antithrombotic agents. Nonetheless, bleeding complications remain frequent and potentially... read more
Resuscitative TEE
The use of ED resuscitative transesophageal echocardiography (TEE) is a practical modality that provides useful diagnostic and therapeutic information for critically ill patients in the emergency department, with an excellent... read more
Advanced Bleeding Control in Combat Casualty Care
Consensus was reached on the contents of a standard bleeding control toolbox, where it should be available, providers and training requirements, international registries and guidelines, and potential indications for REBOA... read more
Bleeding and Thrombotic Events in Patients with Severe COVID‑19 on ECMO
In a nationwide cohort of COVID‑19 patients supported by extracorporeal membrane oxygenation (ECMO), bleeding incidence was high and associated with mortality. Intracranial hemorrhage incidence was higher than reported... read more
MECA in Medical Emergency Situations Significantly Reduced Failure Rates
In our simulation, the use of medical emergency cognitive aid (MECA) in medical emergency situations significantly reduced failure rates. The use of MECA was widely accepted, and MECA were easy to use. In a high percentage,... read more
