Tag: coronavirus
Liver Dysfunction and COVID-19 Infection
Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019 (COVID-19), which predominantly affects the respiratory system; it also causes systemic and multi-organic disease. Liver... read more
Psychological burden in patients with COVID-19 and their relatives 90 days after hospitalization
COVID-19 is linked to clinically relevant psychological distress in a subgroup of patients and their relatives 90 days after hospitalization. If confirmed in an independent and larger patient cohort, knowledge about these... read more
Moderna Vaccine 94.1% Efficacy Preventing Symptomatic COVID-19
The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants... read more
COVID-19 Surges Increased Patient Mortality
A recent study by scientists at the National Institutes of Health suggests that one in every four COVID-19 deaths in the United States may be attributed to hospitals strained by surging caseloads. Published in the Annals... read more
Reduced Sensitivity of COVID-19 Variant Delta to Antibody Neutralization
The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes... read more
Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP
Oxygen therapy and non-invasive ventilation in COVID-19 should be based on pathophysiological changes and a step-by-step approach should be adopted in choosing the right therapeutic strategy for each patient. Continuous... read more
Thrombosis vs. Hemorrhage Rates in Patients with Severe Respiratory Failure Due to COVID-19
Significant rates of pulmonary thromboembolism and of catheter-associated deep vein thrombosis were seen in both viral infections but were greater in those requiring the use of extracorporeal membrane oxygenation in coronavirus... read more
Single-use Endoscopy
Endoscopy is used in a variety of medical specialties ranging from gastroenterology to urology, cardiology and critical care. Traditionally, health systems have invested in reusable endoscopy equipment, but an industrywide... read more
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum
Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe... read more
REGN monoclonal antibodies work in selected hospitalised COVID-19 patients
New findings suggest a significant benefit from REGN in terms of the primary outcome of mortality for patients who have low levels of their own antibodies at the time of admission. This was an unexpected result for me... read more
Percutaneous Dilational Tracheostomy for COVID-19 Patients Requiring Mechanical Ventilation
Patients with COVID-19 who survive the early days of MV experience severe and prolonged respiratory failure. An early modified percutaneous dilational tracheostomy (PDT) was safe for patients and healthcare providers and... read more
Virtual Handover of Patients in the PICU During the COVID-19 Crisis
Video-conferencing applications for online handovers could supplement traditional face-to-face intensive care unit patient handover during outbreaks of infectious diseases. The use of video streaming and more emphasis on... read more
RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more
Imatinib in COVID-19: Hope and Caution
Despite the undoubted progress achieved with the first vaccines against SARS-CoV-2 infection, the COVID-19 pandemic continues to affect thousands of people across the globe, particularly in those countries where vaccination... read more
Breath-holding as a Novel Approach to COVID-19 Risk Stratification
Despite considerable progress, it remains unclear why some patients admitted for COVID-19 develop adverse outcomes while others recover spontaneously. Clues may lie with the predisposition to hypoxemia or unexpected absence... read more
Do Not Attempt CPR Decisions in People Admitted with Suspected COVID-19
Early do not attempt cardiopulmonary resuscitation (DNACPR) decisions were associated with recognised predictors of adverse outcome, and were inversely associated with Asian ethnicity. Most people with an early DNACPR decision... read more
Reducing the Global Sepsis Burden: A Positive Legacy for the COVID-19 Pandemic?
ESICM, SCCM, and the GSA published a consensus paper in Intensive Care Medicine, emphasising the importance of recognising that patients critically ill with COVID-19 have viral sepsis, despite some differences from sepsis... read more
