Tag: coronavirus
Let’s stop the blame game over the ICU beds shortage for COVID-19 patients
The situation in UK intensive care units (ICUs) is grave. Across the UK, units are under immense pressure and are as busy or busier than they were in the first wave. All plans enacted over the summer to provide support for... read more
Allergic Reactions After First Dose of Pfizer-BioNTech COVID-19 Vaccine
Anaphylactic reactions to the first dose of the Pfizer-BioNTech COVID-19 vaccine are rare, usually occur within 30 minutes of administration, and are readily treatable. From December 14-23, 2020, following administration... read more
High-dose Vitamin C in Critically Ill COVID-19 Patients
This pilot trial showed that high-dose intravenous vitamin C (HDIVC) failed to improve IMVFD28, but might show a potential signal of benefit in oxygenation for critically ill patients with COVID-19 improving PaO2/FiO2 even... read more
Colchicine, the only effective oral medication for treating non-hospitalized COVID-19 patients
The Montreal Heart Institute announced COLCORONA clinical trial has provided clinically persuasive results of colchicine's efficacy to treat COVID-19. The study results show that colchicine reduces the risk of death or... read more
Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe
In a small sample, prone positioning non-intubated COVID-19 patients with severe hypoxemia was safe; however, many patients did not tolerate prolonged durations. Although patients had improved oxygenation and respiratory... read more
Full-dose blood thinners decreased need for life support and improved outcomes in COVID-19 patients
Full dose anticoagulation (blood thinner) treatments given to patients hospitalized for COVID-19 reduced the requirement of vital organ support in a large clinical trial conducted worldwide. With large numbers of COVID-19... read more
RAPID UPDATE: Clinical Guide for the Management of Critical Care for Adults with COVID-19
This RAPID UPDATE to the FICM/ICS "Clinical guide for the management of critical care for adults with COVID-19 during the Coronavirus pandemic" highlights five clinically urgent issues for practising clinicians caring for... read more
Tocilizumorelikeit? The latest data on Tocilizumab
Our hats were then blown away when the REMAP-CAP team and the UK government fired an evidence-based carpet bomb in our direction. We saw a trial press release, a preprint article, an alert letter from the MHRA/DHSC, national... read more
ICU Strain and Mortality Risk Among Critically Ill Patients with COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has affected numerous communities, and reports of overburdened hospitals, specifically critical care units, have become commonplace. High-quality supportive care remains the... read more
De Novo Renal Failure and Clinical Outcomes of Patients With Critical COVID-19
This case series concludes that respiratory failure conveys significant mortality risk in patients with coronavirus disease 2019 and that survival with concomitant renal failure is rare. This is a case series of patients... read more
Harnessing a Pioneering Cell Therapy Treatment for COVID-19 Patients with ARF
A world-leading UK-wide trial supported by NIHR is offering a pioneering cell therapy treatment for patients with acute respiratory failure (ARF) caused by COVID-19. The groundbreaking study, led by experts at Queen's... read more
Is Cardiopulmonary Resuscitation Futile in COVID-19 Patients Experiencing In-Hospital Cardiac Arrest?
COVID-19 patients suffering from in-hospital cardiac arrest had 100% in-hospital mortality regardless of the baseline comorbidities, presenting illness severity, and location of arrest. Out of 1,094 patients hospitalized... read more
COVID-19: Antibody-Dependent Enhancement
The simple definition of ADE is “raising antibodies that don’t protect, but actually make a viral infection even worse”. And obviously, that’s the opposite of what you want. Remember that there are “neutralizing”... read more
Bacterial Superinfection Pneumonia in COVID-19 Respiratory Failure
Severe community-acquired pneumonia secondary to SARS-CoV-2 is a leading cause of death. Current guidelines recommend patients with SARS-CoV-2 pneumonia receive empirical antibiotic therapy for suspected bacterial superinfection,... read more
COVID-19 Pneumonia: Typical or Atypical Form of ARDS?
Evidence-based guidelines can never help a doctor resolve whether a patient is best managed by inserting an endotracheal tube or avoiding its use. That decision is based on clinical judgment, gestalt, and tacit knowledge.... read more
Deep RNA Sequencing of ICU Patients with COVID-19
Current upper respiratory tract testing for COVID-19 only determines if the virus is present. Deep RNA sequencing with appropriate computational biology may provide important prognostic information and point to therapeutic... read more
Pre-hospital critical care management of severe hypoxemia in victims of COVID-19
Patients with Covid-19 and severe hypoxemia may pose a considerable challenge for the pre-hospital emergency medical services. Intubation may be associated with a high risk of complications in these patients and should be... read more
Why COVID-19 Pneumonia is More Deadly than Typical Pneumonia
Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung within hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or... read more
ECMO for COVID-19 patients in Europe and Israel
As of October 17th the novel coronavirus (SARS-CoV-2) caused a pandemic disease (coronavirus disease 2019, COVID-19) 40 million people worldwide, with almost one million deaths. Although most patients have an uncomplicated... read more
Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients
Acute brain dysfunction was highly prevalent and prolonged in critically ill patients with COVID-19. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium, and thus these... read more
COVID-19 Blood Plasma Trial Finds No Benefit in Severely Ill Patients
An international trial testing convalescent blood plasma on COVID-19 patients with moderate and severe illness has halted enrolment of severely ill COVID-19 patients requiring intensive care after it found no benefit. The... read more
