Tag: coronavirus
Effect of Helmet Noninvasive Ventilation vs. High-Flow Nasal Oxygen in Patients with COVID-19
Among patients with COVID-19 and moderate to severe hypoxemia, treatment with helmet noninvasive ventilation, compared with high-flow nasal oxygen, resulted in no significant difference in the number of days free of respiratory... read more
SARS-CoV Replication-transcription Complex Can Initiate RNA Synthesis
How viruses from the Coronaviridae family initiate viral RNA synthesis is unknown. Here we show that the SARS-CoV-1 and −2 Nidovirus RdRp-Associated Nucleotidyltransferase (NiRAN) domain on nsp12 uridylates the viral cofactor... read more
COVID-19 Infects Mouth Cells
Scientists have shown that SARS-CoV-2, the virus that causes COVID-19, can infect specific cells in the salivary gland in the mouth. The study by researchers from the Wellcome Sanger Institute, National Institutes of Health... read more
Correlation Between COVID-19 Mortality and Autoantibodies in Patients Treated with Corticosteroids
Auto-reactivity in COVID-19 is increasingly being recognized and may identify a group of patients with inflammation severe enough to result in loss of self-tolerance. Corticosteroids are potent anti-inflammatory agents and... read more
Can Ultrasound Predict Histologic Pattern of Lung Injury in COVID‑19 patient?
We have read with great interest the study by de Almeida Monteiro et al. recently published in Intensive Care Medicine, where authors studied the relationship between histopathological data and lung ultrasonographic (LUS)... read more
An overview of the current AstraZeneca vaccine situation in Europe
On Thursday, March 11, 2021, Denmark suspended the use of the AstraZeneca vaccine (developed in collaboration with the University of Oxford) completely. Some other European countries followed suit. This prompted an investigation... read more
Increased risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1
We started estimating the SARS-CoV-2 reproduction number in the UK using Public Health England data in March 2020, contributing to the Scientific Pandemic Influenza Modelling subgroup (SPI-M) weekly consensus estimates. In... read more
The Influence of Airflow Via High-Flow Nasal Cannula on Duration of Laryngeal Vestibule Closure
The purpose of this experimental study was to investigate the influence of airflow via high-flow nasal cannula (HFNC) on the duration of laryngeal vestibule closure (dLVC) and Penetration-Aspiration Scale (PAS) scores. 29... read more
Outcomes and Risk Factors Associated with COVID-19 Infection of Patients with Multiple Sclerosis
In this registry-based cross-sectional study, increased disability was independently associated with worse clinical severity including death from COVID-19. Other risk factors for worse outcomes included older age, Black race,... read more
Effect of Intermediate-Dose vs. Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, ECMO Treatment, or Mortality Among Patients With COVID-19 in ICU
Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome... read more
Timing of Intubation in Patients With COVID-19
The timing of intubation in hypoxemic patients with COVID-19 has been hotly debated. Early in the pandemic, there was a push to intubate early, driven by the effort to reduce transmission of the virus. With time, high-flow... read more
A Systematic Review of Indoor Air Sampling for COVID-19 Detection
In a post-pandemic scenario, indoor air monitoring may be required seeking to safeguard public health, and therefore well-defined methods, protocols, and equipment play an important role. Considering the COVID-19 pandemic,... read more
Apremilast Not Likely to Reduce Time to Recovery or Mortality in Critically Ill Patients in I-SPY COVID-19 Trial
Quantum Leap Healthcare Collaborative (QLHC), the sponsor of the I-SPY COVID Trial, announced that apremilast (Otezla), made by Amgen, has been dropped for futility. Apremilast was chosen for testing in the I-SPY COVID Trial... read more
Endemic COVID-19 Needs Novel, Prognostic Tests to Predict Severity and Progression
COVID-19 has evolved into a long-term population health problem that requires new types of diagnostics. Diagnostic developers, therefore, are called on to expand their developmental focus to include novel tests to predict... read more
Could a Glass of Wine Diagnose Long COVID?
Acute COVID-19 infection ranges from no symptoms (asymptomatic) to life-threatening. What about long COVID (the symptoms occurring more than three weeks after infection, also known as post-acute COVID syndrome)? Could... read more
Body Mass Index and Risk for COVID-19
Obesity* is a recognized risk factor for severe COVID-19, possibly related to chronic inflammation that disrupts immune and thrombogenic responses to pathogens as well as to impaired lung function from excess weight. Obesity... read more
Convalescent Plasma Doesn’t Prevent Further COVID-19 Progression in At-Risk Patients
Convalescent plasma (CP) from recovered patients with COVID-19 doesn't prevent further COVID-19 progression in at-risk people who visit the emergency room (ER). Early this week, the National Institutes of Health (NIH)... read more
