90 Day Outcomes of COVID-19 Patients in European ICUs

This communication delineates outcomes in COVID-19 patients in the context of ARDS severity, ventilatory management, and variables associated with mortality on a 90-day follow-up for subgroups of patients after ICU admission.... read more

The Blood-Clot Problem Is Multiplying

For weeks, Americans looked on as other countries grappled with case reports of rare, sometimes fatal blood abnormalities among those who had received the AstraZeneca vaccine against COVID-19. That vaccine has not yet... read more

Co-infection in Critically Ill Patients with COVID-19

During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness and death was complicated by bacterial co-infection,... read more

Mortality Outcomes with Hydroxychloroquine and Chloroquine in COVID-19 Patients

Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate... read more

Outcomes of Patients with COVID-19 and Relationship with Lung Ultrasound Signs

In patients with COVID-19 pneumonia, Lung Ultrasound Signs (LUS) signs, including the aeration score, were related to respiratory and systemic symptoms 1 month after ultrasound screening examination. In these patients, a... read more

Understanding The Links Between COVID-19 Vaccines and Thrombosis

The Advisory Committee on Immunization Practices (ACIP) is convening an emergency meeting to discuss adverse events that recently led to thrombotic events in 6 women administered the Johnson & Johnson COVID-19 vaccine in... read more

Sunlight Linked to Lower COVID-19 Deaths

Our analysis suggests that higher ambient UVA exposure is associated with lower COVID‐19 specific mortality. Further research on the mechanism may indicate novel treatments. Optimised UVA exposure may have population health... read more

A Scenario Modeling Pipeline for COVID-19 Emergency Planning

Coronavirus disease 2019 (COVID-19) has caused strain on health systems worldwide due to its high mortality rate and the large portion of cases requiring critical care and mechanical ventilation. During these uncertain... read more

Clinical Features and Predictors in Critically Ill COVID-19 Patients

We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was a multicentered prospective study with clinical and laboratory details. Details for fifty uncomplicated COVID-19... read more

COVID-19: Critical Care and Airway Management Issues

Among patients hospitalized with coronavirus disease 2019 (COVID-19), up to one-quarter require intensive care unit (ICU) admission. Profound hypoxemic respiratory failure from acute respiratory distress syndrome (ARDS)... read more

Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections

Secondary bacterial infections enhance the disease burden of influenza infections substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the synergism between bacterial and viral pathogens, which... read more

ICU-specific Virtual Reality for Psychological Recovery After ICU COVID-19 Treatment

A substantial number of ICU survivors are expected due to the SARS-CoV-2 outbreak, who are at risk for psychological impairments, such as post-traumatic stress disorder (PTSD), anxiety, and depression. We designed a COVID-19... read more

Prone Position in Intubated, Mechanically Ventilated COVID-19 Patients

During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely... read more

Effects of Ventilatory Rescue Therapies on the Cerebral Oxygenation of COVID-19 Patients

A new study by Masimo published in Critical Care evaluated the impact of a variety of rescue therapies on the systemic and cerebral oxygenation of mechanically ventilated COVID-19 patients suffering from acute respiratory... read more

Effect of intubation timing on clinical outcomes of critically ill patients with COVID-19

The synthesized evidence suggests that timing of intubation may have no effect on mortality and morbidity of critically ill patients with COVID-19. These results might justify a wait-and-see approach, which may lead to fewer... read more

Could Physical Therapy Interventions Be Adopted in the Management of Critically Ill Patients with COVID-19?

As part of COVID-19 consequences, it has been estimated that 5% of patients affected by this disease will require admission to the intensive care unit (ICU), and physical therapy techniques have been implemented in patients... read more

People with long-COVID at high risk of ongoing mental health issues

People living with long-COVID are at significant risk of experiencing depression and post-traumatic stress disorder (PTSD), according to research published in the European Respiratory Journal. The research is one of the... read more

Drug Treatments for COVID-19

Corticosteroids and interleukin-6 inhibitors probably confer important benefits in patients with severe covid-19. Janus kinase inhibitors appear to have promising benefits, but certainty is low. Azithromycin, hydroxychloroquine,... read more

On Cytokines, Fluvoxamine and COVID-19

Early in the COVID-19 pandemic, the role of ‘cytokine storm’ in patients with severe course was raised. Indeed, this triggered multiple investigations centred around calming excessive inflammation with pharmacotherapies... read more

Practice Recommendations on Neuraxial Anesthesia and Peripheral Nerve Blocks during the COVID-19 Pandemic

General anesthesia (GA) with airway intervention leads to aerosol generation, which exposes the health care team to risk of transmission of COVID-19 both during intubation and extubation. The odds of transmission of acute... read more

COVID-19 vaccines effective for pregnant women, likely protect their babies too

COVID-19 mRNA vaccines are extremely effective at protecting pregnant and lactating women against the virus, and likely provide protection for their babies as well, according to a study published March 25 in the American... read more

Vaccine-Induced Prothrombotic Immune Thrombocytopenia After AstraZeneca COVID-19 Vaccination

The United Kingdom, European Union, and Scandinavian countries have reported that the AstraZeneca COVID-19 vaccine appears to be associated with rare cases of serious blood clots, including blood clots in the brain. These... read more