Predictive Biomarkers of Mortality in ICU Patients with Severe COVID-19

This study shows changes in hematological, biochemical, and inflammatory parameters in COVID-19 non-surviving patients. Lymphopenia, neutrophilia, and thrombocytopenia, as well as increased levels of CRP, AST, creatinine,... read more

Factors Affecting the Duration of Hospitalization in Urology and Nephrology Patients in the ICU

Factors affecting ICU stay length in Urology and Nephrology patients who required close monitoring and specialized medical staff were investigated. The study found a positive association between prolonged ICU stays and elevated... read more

Using Diuretic Therapy in the Critically Ill Patient

Using Diuretic Therapy in the Critically Ill Patient

Diuretics are routinely prescribed in critically ill patients but significant variation in practice exists. In this article, we summarize current data relevant to diuretic prescribing. What are the indications for diuretics... read more

AKI Risk Factors in ICU Patients Using Colistin

AKI Risk Factors in ICU Patients Using Colistin

Colistin, an antibiotic of polymyxin group, has recently been increasingly used in the treatment of multidrug resistant gram-negative bacteria. However, it has serious adverse effects such as acute kidney injury (AKI). We... read more

Omadacycline Treatment of Severe Pneumonia Complicated with ARDS During COVID-19

Omadacycline Treatment of Severe Pneumonia Complicated with ARDS During COVID-19

Metagenomic next-generation sequencing (mNGS) has a significant value in the diagnosis of Chlamydia psittaci infection. Timely treatment of omadacycline can improve prognosis and provide a promising new option for the treatment... read more

Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU

Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU

We analyzed unvaccinated critically ill ICU patients with COVID-19 and interpreted their demographics, clinical characteristics, comorbidities, and laboratory data upon ICU admission for a better understanding of their impact... read more

Urine Output-based Sepsis-associated AKI: Clinical Implications

Urine Output-based Sepsis-associated AKI: Clinical Implications

This paper offers comprehensive insights into the epidemiology of acute kidney injury (AKI), and we commend the authors for their significant contribution. They revealed an increase in the number of mild cases among AKI stage... read more

PLASMIC Score Role in the Management of Thrombotic Thrombocytopenic Purpura

PLASMIC Score Role in the Management of Thrombotic Thrombocytopenic Purpura

At centers that are resource-limited and where ADAMTS-13 testing is not readily available, it is imminent that treatment is started immediately based on the clinical presentation and PLASMIC score. A PLASMIC score can... read more

Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C

Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C

Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true injury or a pseudotoxicity characterized... read more

Acute Kidney Injury Related to Intoxication From Synthetic Cannabis

Acute Kidney Injury Related to Intoxication From Synthetic Cannabis

Acute kidney injury (AKI) occurs infrequently in young patients and often raises concern for irreversible or deadly etiologies. However, AKI related to synthetic marijuana, colloquially known as K2, is an increasingly common... read more

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin use is associated with a 26% raised risk of heart failure in people with at least one predisposing factor for the condition. That’s the finding of a study published today in ESC Heart Failure, a journal of the European... read more

Endothelial Glycocalyx Degradation Contributes to Metabolic Acidosis in Children After Cardiopulmonary Bypass Surgery

Endothelial Glycocalyx Degradation Contributes to Metabolic Acidosis in Children After Cardiopulmonary Bypass Surgery

Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary... read more

Contrast-enhanced Imaging in the Emergency Department

Contrast-enhanced Imaging in the Emergency Department

We continue with the topic of Contrast-enhanced imaging in the emergency department. "What is the creatinine?" asks the radiologist when an emergency contrast-enhanced computed tomography (CT) is requested for a patient with... read more

The Feasibility of Studying Metabolites in PICU MODS

The Feasibility of Studying Metabolites in PICU MODS

Metabolites are generated from critical biological functions and metabolism. This pediatric study reviewed plasma metabolites in patients suffering from multi-organ dysfunction syndrome (MODS) in the pediatric intensive care... read more

AKI Epidemiology, Risk factors, and Outcomes in Critically Ill Patients 16-25 Years of Age Treated in an Adult ICU

AKI Epidemiology, Risk factors, and Outcomes in Critically Ill Patients 16-25 Years of Age Treated in an Adult ICU

Using the KDIGO criteria for both serum creatinine and urine output to define acute kidney injury (AKI), 39.8% of patients between the ages of 16–25 met AKI criteria during admission to an adult tertiary care center, indicating... read more

Clinical Decision Support Systems: Future or Present in ICU?

Clinical Decision Support Systems: Future or Present in ICU?

Clinical decision support systems (CDSS) are today, a reality. More complex, useful systems will be developed in the near future, forging CDSS an essential part of ICU monitoring. However, we need to understand the algorithms... read more

Hyperchloremia Is Associated With AKI in Patients With Subarachnoid Hemorrhage

Hyperchloremia Is Associated With AKI in Patients With Subarachnoid Hemorrhage

Critically ill patients with subarachnoid hemorrhage show a strong association between hyperchloremia and acute kidney injury as well as acute kidney injury and mortality. Of 1,267 patients included in this cohort, 16.7%... read more