Tag: delirium
Dexmedetomidine vs. Propofol Sedation in Critically Ill Adults Requiring Mechanical Ventilation
Dexmedetomidine did not significantly impact ICU length of stay compared with propofol, but it significantly reduced the duration of mechanical ventilation and the risk of delirium in cardiac surgical patients. It also significantly... read more
Feelings of Strangeness in ICU Patients
After several weeks in the intensive care unit (ICU) following a lung infection, Mr Pol wakes up from a coma and gradually becomes aware of his situation. The healthcare team rejoice in the successful outcome of his extubation:... read more
Difficulties Faced by Nurses Who Care For Patients with Delirium in the ICU
We developed a difficulty scale for nurses caring for patients with delirium in the intensive care unit and confirmed its reliability and validity. The difficulty factors were developed with the intention to identify educational... read more
Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients
Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32)... read more
The Family in Preventing Delirium in the ICU
Extended visits, development of family-mediated activities, and redirection are non-pharmacological strategies that reduce the incidence of delirium in the ICU and offer multiple benefits to the patient and family/caregiver. The... read more
Melatonin in ICU Delirium: Shining Light on the Hormone of Darkness
Delirium represents a form of acute brain dysfunction predictive of excess death and long-term cognitive impairment in critically ill patients. For many years, we have wondered whether pharmacological doses of melatonin would... read more
Incidence of Delirium in ICU Inpatients After Cognitive Exercise Intervention
In this study, the relevant RCTs on cognitive exercise in ICU inpatients with delirium were screened for systematic evaluation and meta-analysis, aiming to explore the impact of cognitive exercises and routine nursing on... read more
Processed Electroencephalography-guided General Anaesthesia to Reduce Postoperative Delirium
Our primary analysis demonstrated a highly sensitive result with a pooled analysis of trials in which the intervention group adhered to manufacturer's recommended guidelines showing reduced incidence of postoperative delirium... read more
Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC)
Enteral melatonin initiated within 48 h of ICU admission did not reduce the prevalence of delirium compared to placebo. These findings do not support the routine early use of melatonin in the critically ill. A total of... read more
Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score
The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S) is an automated, physiologic measure of delirium severity that predicts clinical outcomes with a level of performance comparable to conventional... read more
Association Between Incident Delirium Treatment with Haloperidol and Mortality in Critically Ill Adults
Treatment of incident delirium and its symptoms with haloperidol may be associated with a dose-dependent improvement in survival. Future randomized trials need to confirm these results. Patients were evaluated tid for... read more
Post-acute Neurological Consequences of COVID-19
COVID-19 and its neurological consequences particularly burden marginalized communities, and so can only be effectively treated by advancing health equity. Our world has witnessed over 275 million confirmed cases of COVID-19... read more
Preoperative POCUS to Identify Frailty and Predict Postoperative Outcomes
Similar to computed tomography measurements of psoas muscle area, preoperative ultrasound measurements of quadriceps depth shows promise in discriminating between frail and not-frail patients before surgery. It was also associated... read more
Dynamic Delirium Severity Trajectories and Healthcare Utilization
This secondary analysis did not identify a significant relationship between delirium severity trajectories and healthcare utilization or mortality within 2 years of hospital discharge. The overall sample (n = 431) had... read more
Point of Care Venous Doppler Ultrasound
Accurate assessment of the hemodynamic status is vital for appropriate management of patients with critical illness. As such, there has been a constant quest for reliable and non-invasive bedside tools to assess and monitor... read more
The Nexus Between Sleep Disturbance and Delirium Among Intensive Care Patients
Sleep in intensive care is hampered due to many factors; the clinical environment itself exacerbates sleep disturbance. Research suggests that interventions aimed at improving sleep quality have produced positive effects... read more
Perioperative Dexmedetomidine on the Incidence of Postoperative Delirium
Delirium occurs commonly following major non-cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive dysfunction; increased length of hospital stay; and major postoperative... read more
Impact of ABCDE Bundle Implementation in the ICU on Specific Patient Costs
Full ABCDE bundle implementation resulted in a decrease in total hospital laboratory costs and total hospital laboratory and diagnostic resource utilization while leading to an increase in physical therapy costs. The full... read more
Melatonin for Delirium Prevention in Hospitalized Patients
Melatonin/ramelteon are associated with reduction in delirium incidence in hospitalized patients. However, this effect seems confined to surgical and ICU patients. The optimum dosage and formulation of melatonin, and... read more
Dealing with missing delirium assessments in prospective clinical studies of the critically ill
For longitudinal data where a summary exposure is of interest, we recommend practitioners adopting the passive imputation strategy. Simulations show that all methods performed comparably when the proportion of missingness... read more
The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness
The advent of modern critical care medicine has revolutionized care of the critically ill patient in the last 50 years. The Society of Critical Care Medicine (was formed in recognition of the challenges and need for specialized... read more
