Improving Spontaneous Breathing Trials With a Respiratory Therapist-Driven Protocol

This quality improvement (QI) project aimed to standardize and re-establish RT-driven protocol for screening patients for SBT readiness and administering SBTs to appropriate patients. Endotracheally intubated and mechanically... read more

Improving Spontaneous Breathing Trials With a Respiratory Therapist-Driven Protocol

Tezepelumab in a case of severe asthma exacerbation and influenza-pneumonia on VV-ECMO

We present a case of 43-year-old male patient with broadly by Omalizumab, Mepolizumab and Benralizumab pretreated allergic asthma, who suffered a near fatal exacerbation, triggered by an influenza A infection. Due to... read more

Tezepelumab in a case of severe asthma exacerbation and influenza-pneumonia on VV-ECMO

A nomogram predicting pneumonia after cardiac surgery

Three preoperative indicators (age, preoperative malnutrition, diabetes mellitus), one intraoperative indicator (CPB > 135 min) and three postoperative indicators (moderate to severe ARDS, use of ECMO or IABP or CRRT, MV>... read more

A nomogram predicting pneumonia after cardiac surgery

Prone Positioning During ECMO for Severe ARDS

The ongoing debate on optimal extracorporeal membrane oxygenation (ECMO) care emphasizes the need for rigorous investigation, acknowledging the value of observational data in routine The PRONECMO study, with its pragmatic... read more

Prone Positioning During ECMO for Severe ARDS

Managing the Cerebral Complications of ARDS

Acute respiratory distress syndrome (ARDS) comprises 10–30% of critical care admissions worldwide. ARDS outcomes have improved secondary to ventilatory strategies that may potentially mitigate ventilator-induced lung injury.... read more

Managing the Cerebral Complications of ARDS

ARDS Guidelines: Oceans Apart or Rivers That Merge?

The updated guidelines from the ATS and ESICM reached overwhelmingly similar conclusions. Both sets of guidelines emphasize the challenges in issuing blanket recommendations that apply to all patients with ARDS, and both... read more

ARDS Guidelines: Oceans Apart or Rivers That Merge?

Extracorporeal Life Support for Adults

This book presents a concise, evidence-based review of extracorporeal life support (ECLS) for adult diseases. It describes the use of ECLS with patients who are experiencing severe hypoxemic respiratory failure (ARDS and... read more

Extracorporeal Life Support for Adults

Platelets and Fibrinogen Matter When Bleeding on ECMO

Fibrinolysis is poorly investigated in ECMO patients, partly due to a lack of routine laboratory tests evaluating fibrinolysis. Hence, hyperfibrinolysis may be a contributor to bleeding risk during ECMO treatment. However,... read more

Platelets and Fibrinogen Matter When Bleeding on ECMO

ECPR in 2023

Extracorporeal cardiopulmonary resuscitation (ECPR) is invasive and resource intense. Data suggesting a survival benefit in patients after OHCA and ECPR derive from retrospective registries and meta-analyses. In order to... read more

ECPR in 2023

Propofol-Related Infusion Syndrome in a Child with RSE

Propofol is used for sedation, anxiolysis, anesthesia induction, and as an anticonvulsant. In cases of refractory status epilepticus (RSE), propofol is more efficient than barbiturates. We present a case of a 3-year-old... read more

Propofol-Related Infusion Syndrome in a Child with RSE

Age and Associated Outcomes Among Patients Receiving V-A ECMO

In a multinational study using the ELSO Registry, we found that increasing age was strongly associated with higher risk of hospital mortality and complications among patients receiving V-A ECMO for cardiogenic shock, with... read more

Age and Associated Outcomes Among Patients Receiving V-A ECMO

Revisiting VA-ECMO in Infarct-related Cardiogenic Shock

Despite advances in medical therapies and coronary revascularization, infarct-related cardiogenic shock remains a life-threatening emergency with high death rates. Temporary mechanical circulatory support, including peripheral... read more

Revisiting VA-ECMO in Infarct-related Cardiogenic Shock

Using Deep Neural Networks for Survival Prediction in VA-ECMO

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a complex and high-risk life support modality used in severe cardiorespiratory failure. ECMO survival scores are used clinically for patient prognostication... read more

Using Deep Neural Networks for Survival Prediction in VA-ECMO

Anticoagulation in the ICU: Contact Pathway Inhibition Future

Bleeding and thrombotic complications are the main cause of morbidity and mortality in critically ill patients on the intensive care unit (ICU), receiving short-term percutaneous mechanical circulatory support (pMCS) by extracorporeal... read more

Anticoagulation in the ICU: Contact Pathway Inhibition Future

The impact of diabetes mellitus on morbidity and mortality in patients with COVID-19

During the COVID-19 pandemic, healthcare delivery was affected in various ways. For example, acute and chronic cardiovascular diseases (CVDs) and events were less frequently observed in hospitals, both because public health... read more

The impact of diabetes mellitus on morbidity and mortality in patients with COVID-19

Updated Systematic Review on Remdesivir’s Safety and Efficacy in COVID-19 Patients

Remdesivir, an antiviral medication, may benefit patients who are infected with mild or moderate forms of COVID-19 infection. Several research findings have suggested the safety and efficacy of remdesivir for a five- to 10-day... read more

Updated Systematic Review on Remdesivir’s Safety and Efficacy in COVID-19 Patients

VA-ECMO in High-Risk Pulmonary Embolism

High-risk Pulmonary Embolism (PE) has an ominous prognosis and requires emergent reperfusion therapy, primarily systemic thrombolysis (ST). In deteriorating patients or with contraindications to ST, Veno-Arterial Extracorporeal... read more

VA-ECMO in High-Risk Pulmonary Embolism

Verticalization Therapy for ARDS Patients Receiving VV-ECMO

Persistent hypoxemia during veno-venous extracorporeal membrane oxygenation (VV-ECMO) for supporting acute respiratory distress syndrome (ARDS) patients is a clinical challenge for intensive care medical providers. Prone... read more

Verticalization Therapy for ARDS Patients Receiving VV-ECMO

Prostacyclin Anticoagulation Efficacy in Critically Ill Patients Requiring Extracorporeal Support

Extracorporeal support modalities are highly prothrombotic. Anticoagulation is frequently used for patients receiving Continuous Renal Replacement Therapy (CRRT), Molecular Adsorbent Recirculating System (MARS), and Extracorporeal... read more

Prostacyclin Anticoagulation Efficacy in Critically Ill Patients Requiring Extracorporeal Support

Barotrauma Rate Is 25% in ARDS Patients Receiving ECMO

Patients with acute respiratory distress syndrome (ARDS) receiving mechanical ventilation have a high risk of barotrauma, which often has poor prognosis and high mortality. Although ECMO should theoretically protect patients... read more

Barotrauma Rate Is 25% in ARDS Patients Receiving ECMO

Heparin-based vs. Bivalirudin-based Anticoagulation in Pediatric ECMO

Bivalirudin may be a safe, cost-effective alternative to heparin in achieving anticoagulation in pediatric extracorporeal membrane oxygenation (ECMO) patients. Prospective multicenter studies and randomized control trials... read more

Heparin-based vs. Bivalirudin-based Anticoagulation in Pediatric ECMO

ECMO in Adult Patients Receiving HCT

Combined advances in hematopoietic cell transplantation (HCT) and intensive care management have improved the survival of patients with hematological malignancies admitted to the intensive care unit. In cases of refractory... read more

ECMO in Adult Patients Receiving HCT