Bridging the Gap Between Intensivists and Primary Care Clinicians in ECMO for Respiratory Failure in Children

All pediatric clinicians should be aware not only of the potential benefits and complications of ECMO but also that survivors need effective screening, support, and follow-up. The 2009 influenza A(H1N1) pandemic, along... read more

Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines

Survival rates with good neurologic outcomes following conventional cardiopulmonary resuscitation (CPR) for cardiopulmonary arrest, either in the in-hospital (IH) or out-of-hospital settings, have improved but remain poor... read more

Insight into ECMO, mortality and ARDS

ARDS is a severe disease with a high mortality rate despite ECLS therapy. Although endpoints and timing of the evaluations differed from those of the CESAR and EOLIA studies and the Extracorporeal Life Support Organization... read more

EROCA: Results of a Randomized Feasibility Trial of Expedited Out-of-Hospital Transport

Outcomes of extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest depend on time to therapy initiation. We hypothesize that it would be feasible to select refractory out-of-hospital cardiac... read more

Timing, Outcome, and Risk Factors of Intracranial Hemorrhage in ARDS Patients During VV-ECMO

Intracranial hemorrhage occurs early during venovenous extracorporeal membrane oxygenation (VV-ECMO) and is a determinant for 60-day mortality. Appropriate adjustment of identified modifiable risk factors might lower... read more

Tocilizumorelikeit? The latest data on Tocilizumab

Our hats were then blown away when the REMAP-CAP team and the UK government fired an evidence-based carpet bomb in our direction. We saw a trial press release, a preprint article, an alert letter from the MHRA/DHSC, national... read more

ECMO for COVID-19 patients in Europe and Israel

As of October 17th the novel coronavirus (SARS-CoV-2) caused a pandemic disease (coronavirus disease 2019, COVID-19) 40 million people worldwide, with almost one million deaths. Although most patients have an uncomplicated... read more

Trauma ICU Rounds – The rEVOLUTION of ECMO

What are the indications for ECMO beyond ARDS and refractory cardiogenic shock? In which patients should we consider eCPR and is this the new standard of care for patients sustaining out-of-hospital cardiac arrest? Finally,... read more

Risk Factors of Ischemic and Hemorrhagic Strokes During Venovenous ECMO

Among venovenous extracorporeal membrane oxygenation patients in the Extracorporeal Life Support Organization registry, approximately 5% had acute brain injury. Mortality rates increased two-fold when ischemic or hemorrhagic... read more

Venoarterial ECMO in Elderly Patients with Refractory Cardiogenic Shock

The clinical utilization of extracorporeal membrane oxygenation (ECMO) has seen remarkable expansion since its inception in the early 1970s, including a period of exponential growth in the United States. Venoarterial... read more

Extracorporeal Membrane Oxygenation for COVID-19

The coronavirus disease 2019 (COVID-19) pandemic has placed extraordinary strain on global healthcare systems. Use of extracorporeal membrane oxygenation (ECMO) for patients with severe respiratory or cardiac failure attributed... read more

Prediction of Neurological Outcomes in Patients Treated With ECPR

This prognostic study develops and validates a prediction model for neurological outcomes of patients with out-of-hospital cardiac arrest with shockable rhythm treated with extracorporeal cardiopulmonary resuscitation. A... read more

Improved Oxygenation After Prone Positioning May Be a Predictor of Survival in Patients With ARDS

We found a significant difference in the Pao2:Fio2 ratio after the first prone positioning between ICU survivors and nonsurvivors. The improvement in oxygenation after the first prone positioning was a significant predictor... read more

The Feasibility of Studying Metabolites in PICU MODS

Metabolites are generated from critical biological functions and metabolism. This pediatric study reviewed plasma metabolites in patients suffering from multi-organ dysfunction syndrome (MODS) in the pediatric intensive care... read more

Will the asthma revolution fostered by biologics also benefit adult ICU patients?

Asthma exacerbations are inflammatory events that rarely result in full hospitalization following an ER visit. Unfortunately, certain patients require prolonged support, including occasional external lung support through... read more

Implantation of Impella CP Left Ventricular Assist Device Under the Guidance of 3D Intracardiac Echocardiography

Three-dimensional intracardiac echocardiography is a feasible option to guide implantation of the Impella CP for left ventricular mechanical support and should be carefully considered in cases where other imaging modalities... read more

Some Signs of Recovery From Severe COVID-19 Lung Damage

In two early studies, researchers said some patients showed signs of healing just weeks after leaving the hospital. Lingering shortness of breath and diminished stamina have dogged many COVID patients whose lungs were... read more

Clinical and Pathophysiologic Aspects of ECMO-associated Hemorrhagic Complications

Extracorporeal membrane oxygenation (ECMO) is increasingly used to treat severe cases of acute respiratory or cardiac failure. Hemorrhagic complications represent one of the most common complications during ECMO, and can... read more

Brain Injury Is More Common in vv-ECMO Than VA-ECMO

Brain injury was more common in venoarterial extracorporeal membrane oxygenation (VA-ECMO) compared with venovenous extracorporeal membrane oxygenation (vv-ECMO). While ischemic brain injury was more common in venoarterial... read more

Extracorporeal Cytokine Adsorption as an Alternative to Pharmacological Inhibition of IL-6 in COVID-19

With great interest we read the article by Convertino et al. discussing potential treatment targets for pharmacological immunomodulation in coronavirus disease 2019 (COVID-19) with acute respiratory distress syndrome (ARDS).... read more

Critical Care Medicine: Principles of Diagnosis and Management in the Adult

Now completely revised to bring you up to date with the latest advances in the field, Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 5th Edition, delivers expert, practical guidance on virtually... read more

Critical Care Medicine: Principles of Diagnosis and Management in the Adult

Thrombosis and Bleeding in ECMO without Anticoagulation

Extracorporeal membrane oxygenation (ECMO) causes both thrombosis and bleeding. Major society guidelines recommend continuous, systemic anticoagulation to prevent thrombosis of the ECMO circuit, though this may be undesirable... read more