Failure to Rescue in ALF

The concept of failure to rescue has been used to measure the quality of care for complications developed following surgery. In patients with acute liver failure (ALF), the concept of failure to rescue highlights the... read more

Textbook of Neurointensive Care: Volume 1: Neuroanatomy, Diagnostic Assessment, Disease Management

This extensively updated edition provides a comprehensive review of intensive care for neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period in two comprehensive... read more

Textbook of Neurointensive Care: Volume 1: Neuroanatomy, Diagnostic Assessment, Disease Management

Oral Health Care and VAP in ICU Patients

Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more

Prone Position: Achieving Nutritional Goals

Critically ill patients in the prone position had longer hospital stays and higher mortality rates, while being more likely to initiate and remain on enteral nutrition for a longer period. However, no significant differences... read more

Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence... read more

Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

Different Anticoagulation Regimens Effectiveness in Critically Ill Patients

This study compared the efficacy of therapeutic anticoagulation guided by anti-Xa levels vs. a D-dimer-based protocol in ICU patients with COVID-19. Given the heightened risk of thrombosis despite anticoagulation therapy... read more

Methylprednisolone vs. Hydrocortisone in Septic Shock Patients

Corticosteroids play an important role in the management of septic shock patients, especially in those with higher doses of vasopressor. However, the therapeutic benefits of corticosteroids are not limited to hydrocortisone... read more

Elevated BCR Risk Factor For CHF in Critically Ill COPD Patients

Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and death. The blood urea nitrogen-to-creatinine ratio (BCR) is recognized as a crucial marker to assess renal function and cardiovascular... read more

Patients Under Mechanical Ventilation Are Highly Perceptive

This meta-synthesis provides insights into the perception of intensive care patients under Mechanical Ventilation (MV) who are continuously observing their own lives. This process is complex and involves a highly differentiated... read more

Hemoglobin Glycation Index vs. Adverse Outcomes in Critically Ill Patients with Myocardial Infarction

Based on the MIMIC-IV database, this study found that lower HGI is significantly associated with an increased risk of short-, mid- and long-term all-cause mortality in critically ill myocardial infarction (MI) patients. As... read more

Thromboprophylaxis Preferences in the ICU

Low-molecular-weight heparin (LMWH) was the preferred agent for thromboprophylaxis in critically ill patients. There was considerable variation in the application of LMWH for prophylaxis, reflected by the use of different... read more

Machine Learning Model for Predicting Acute Pancreatitis Mortality in the ICU

Machine learning model has been proved to be superior to existing prediction scores for mortality prediction of Acute Pancreatitis (AP). The use of most of previous ML models is limited in clinical practice, mainly due... read more

Electrical Impedance Tomography for PEEP Titration in ARDS Patients

ARDS patients may benefit from electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration. The real-time bedside assessment of regional ventilation provided by EIT may result in improved... read more

Association Between Aspirin and AKI in Critical Patients with Chest Trauma

This analysis of two datasets reveals that aspirin usage is associated with an increased risk of acute kidney injury (AKI) in critical patients with chest trauma; however, no significant association was observed between the... read more

Predicting SA-AKI Mortality Using XGBoost Algorithm

The integration of advanced techniques with the XGBoost algorithm yielded a highly accurate and interpretable model for predicting Sepsis-Associated Acute Kidney Injury (SA-AKI) mortality across diverse populations. It... read more

Pharmacokinetics of Opioid Infusions in the Adult ICU Setting

To counter these pharmacokinetics (PKs) alterations, new therapeutic avenues must be further explored in the ICU to individualize opioid infusions. Embase, MEDLINE, PubMed, CINAHL, and Evidence-Based Medicine Reviews (EBMR)... read more

Clinical Efficacy of Nafamostat Mesylate-assisted CRRT Therapy in SA-AKI Patients

Nafamostat Mesylate (NM)-assisted continuous renal replacement therapy (CRRT) therapy significantly improves the therapeutic efficacy of patients with sepsis-associated acute kidney injury (SA-AKI). This combined approach... read more

Impact of Short-Acting Beta-Blockers on the Outcomes of Septic Shock Patients

In patients with septic shock, short-acting beta-blockers may improve survival and reduce new-onset tachyarrhythmias. However, these findings were based on low certainty evidence and given ongoing concerns regarding adverse... read more

Thiamine and Ascorbic Acid in Sepsis and Septic Shock

Exploring the individual and synergistic effects of ascorbic acid and thiamine on key pathways implicated in sepsis pathophysiology has not yielded unequivocal evidence supporting their use without concomitant corticosteroids. Heterogeneity... read more

Evaluation of Vitamin D Supplementation in Critically Ill Patients

Vitamin D supplementation in critically ill patients may shorten ICU or hospital length of stay, improve SOFA scores, or reduce the duration of mechanical ventilation. Its ability to lower 28-day mortality remains uncertain,... read more

ARDS Predictors in ICU Patients with Sepsis Using Dynamic Immune Indicator Changes

This study underscores the pivotal role of dynamic immune indicator changes in predicting acute respiratory distress syndrome (ARDS) development among ICU sepsis patients. By incorporating immune cell and immunoglobulin dynamics... read more

Alcohol Consumption Association with the Risk of Bacterial Infection and Pneumonia

Alcohol consumption has a nonlinear J-shaped dose–response association with the risk of acquiring and dying due to bacterial infection and pneumonia, where moderate consumption between one-half and four UK units per day... read more