Delirium Prevention in the ICU: Melatonin or Ramelteon

Melatonin modulates the circadian rhythm and has been studied as a preventive measure against the development of delirium in hospitalized patients. Such an effect may be more evident in patients admitted to the ICU, but findings... read more

Delphi Approach to 5-level Priority Triage Systems

This study proposes a standard of 49 outcomes divided into two sets tied to red and orange priority respectively, to be used when evaluating 5-level priority triage systems; Lund Outcome Set for Evaluation of Triage (LOSET).... read more

Predicting Readmission or Death After Discharge From the ICU with Machine Learning

In this era of expanding availability of ML models, external validation and retraining are key steps to consider before applying machine learning (ML) models to new settings. Clinicians and decision-makers should take... read more

Increased Risk of Hospitalization in Celiac Disease with COVID-19 Infection Is Mitigated by Vaccination

Celiac disease (CD) patients with COVID-19 have a higher risk of hospitalization compared with non-CD referents. This risk is mitigated by vaccination in CD patients as it is in non-CD referents. ICU requirement occurred... read more

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

The study evaluated the use of heart rate variability (HRV) to predict the outcome of patients in the ICU. HRV is a way to evaluate the cardiac effects of the autonomic nervous system, and a relation between HRV and outcome... read more

A Young Doctor’s Perspective Was Forever Changed by ICU Experience

A healthy 30-year-old doctor had an unexpected medical emergency while preparing for a procedure, which led to the discovery of a small hemorrhage in her dorsal brainstem. She was transferred to the neuro ICU and experienced... read more

I Was a Doctor Through COVID. Then One Case Pushed Me Over the Edge

On some days I can almost forget that COVID ever happened. The old rhythms of the ICU at University College London, where I am a consultant in critical care and anesthesia, have returned. The bed pressures, the worrying cases,... read more

Life Lessons After a Career in Intensive Care Medicine

I have spent the past 30 years working in intensive care medicine. I was drawn to intensive care as a trainee for several reasons. First, I enjoyed the opportunity to care for the sickest patients in the hospital and to use... read more

Bayesian Reanalysis of the Standard vs. Accelerated Initiation of RRT in AKI Trial

Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy (RRT) in Acute Kidney Injury (STARRT-AKI)... read more

Use of Cardiac POCUS in Diagnosis of HFrEF in a Patient with Ischemic Stroke

Ischemic strokes in younger adults, those 18 to 50 years old, account for approximately 10% to 15% of all ischemic strokes. Risk factors for stroke between younger and older patients tend to be similar. Younger patients... read more

Acid-Base Disorders in the Critically III Patient

Acid-base disorders are common in the intensive care unit. By utilizing a systematic approach to their diagnosis, it is easy to identify both simple and mixed disturbances. These disorders are divided into four major categories:... read more

Clinical Applications of Magnets on Cardiac Rhythm Management Devices

The growing indications for permanent pacemaker and implantable cardioverter defibrillator (ICD) implantation have increased the number of patients with these cardiac rhythm management devices (CRMDs). Cardiac rhythm... read more

Mechanical Ventilation for the ICU Resident: A Concept Based Approach

This book is written primarily with the intent of helping medical residents understand the basics of mechanical ventilation. It is meant to be read during a one-month rotation in the ICU. It is a compilation of concepts... read more

Mechanical Ventilation for the ICU Resident: A Concept Based Approach

House Officer’s Guide to ICU Care

Your Must-Have Guide for Navigating the ICU The House Officer's Guide to ICU Care is an eminently practical handbook for junior house officers, medical students, PAs, and nurses that offers nuts-and-bolts guidelines for optimal... read more

House Officer’s Guide to ICU Care

Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients

Feed intolerance (FI) is common in critically-ill cirrhosis patients and non-resolution carries high mortality. Early recognition and treatment with prokinetics is recommended to improve short-term survival. Of the 1,030... read more

Current Practice Updates in Emergency Medicine

Medicine is an ever-growing specialty. With new research and trials being conducted frequently, it becomes difficult to remain updated on the subject by just reading the textbook. Moreover, the postgraduate examination also... read more

Current Practice Updates in Emergency Medicine

Plasma Exchange in the ICU

In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement... read more

Septic Shock Developing Later During Hospital Stay Associated with Higher Mortality

In-hospital mortality continued to rise as admission-shock-onset-time increased in patients with septic shock. No clear dichotomization between early and late septic shock could be ascertained, and this categorization may... read more

Care Step Pathway an Effective Tool For Clinicians Caring for Mechanical Ventilated COVID-19 Patients

The Care Step Pathway (CSP) described in this article was developed to increase awareness of the potential association of SARS-CoV-2 infection with invasive fungal infections, particularly pulmonary aspergillosis. The... read more

Dexmedetomidine vs. Propofol Sedation in Critically Ill Adults Requiring Mechanical Ventilation

Dexmedetomidine did not significantly impact ICU length of stay compared with propofol, but it significantly reduced the duration of mechanical ventilation and the risk of delirium in cardiac surgical patients. It also significantly... read more

The Effect of ICU Diaries on PTSD, Anxiety, and Depression

Providing an ICU diary to patients admitted to the ICU reduced the rate of posttraumatic stress disorder (PTSD) symptoms compared with usual care. We included 7 RCTs. Patients who received a diary during the ICU admission... read more

Etomidate, Adrenal Insufficiency and Mortality Associated with Severity of Illness

Whereas etomidate causes adrenal insufficiency, it was not shown to increase mortality in many analyzed here in ICU settings. However, etomidate associated relative mortality rates increased progressively and correlated with... read more