Haloperidol, Clonidine and Resolution of Delirium in Critically Ill Patients

Haloperidol and clonidine use in delirious ICU patients may be associated with reduced probability of delirium resolution. This finding, however, merits further investigation given inherent limitations of this observational... read more

Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?

COVID-19 is an infectious respiratory disease caused by a coronavirus called SARS-CoV-2. If the infection becomes severe, people may need intensive care and support in hospital, including mechanical ventilation. Drugs... read more

Surviving Sepsis Campaign Guidelines on the Management of Adults with COVID-19 in the ICU

The Surviving Sepsis Campaign Coronavirus Disease 2019 panel issued several recommendations to guide healthcare professionals caring for adults with critical or severe coronavirus disease 2019 in the ICU. Based on a living... read more

Resident competencies before and after short ICU rotations

A monthly multi-competency assessment for specialty residents rotating in the ICU is likely feasible for most programs with appropriate resources, and generally acceptable for residents. Specialty residents' cognitive reasoning... read more

Pharyngeal abscess: a rare complication of repeated nasopharyngeal swabs

A 73-year-old end-stage renal disease patient who had undergone craniopharyngioma resection 30 years previously was admitted to hospital after a fall. He developed hospital-acquired laboratory-confirmed SARS-CoV-2 that required... read more

Priorities in Critical Care Nursing

With its succinct coverage of all core critical care nursing topics, this evidence-based text is the perfect resource for both practicing nurses and nursing students alike. Using the latest, most authoritative research, this... read more

Priorities in Critical Care Nursing

Opioid Use After Intensive Care

Mean opioid consumption is increased 24 months after ICU admission despite the lack of evidence for long-term opioid treatment. Given the high number of ICU entries and risk of excess mortality for chronic users, preventing... read more

Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19

Delirium without coma occurred in 29.1% of patients admitted to the ICU. Delirium persisted for a median of 5 days and was severe. Mechanical ventilation was significantly associated with odds of delirium even after adjustment... read more

Effectiveness of Bundle Interventions on ICU Delirium

This meta-analysis fails to support that bundle interventions are effective in reducing ICU delirium prevalence and duration, but supports that bundle interventions are effective in reducing the proportion of patient-days... read more

Mortality of Older Patients Admitted to an ICU

In this systematic review of older patients admitted to intensive care, we have documented substantial variation in short- and long-term mortality as well as in prognostic factors evaluated. To better understand this... read more

Full-dose blood thinners decreased need for life support and improved outcomes in COVID-19 patients

Full dose anticoagulation (blood thinner) treatments given to patients hospitalized for COVID-19 reduced the requirement of vital organ support in a large clinical trial conducted worldwide. With large numbers of COVID-19... read more

Tocilizumorelikeit? The latest data on Tocilizumab

Our hats were then blown away when the REMAP-CAP team and the UK government fired an evidence-based carpet bomb in our direction. We saw a trial press release, a preprint article, an alert letter from the MHRA/DHSC, national... read more

Antimicrobial‑associated Harm in Critical Care

The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents. Antimicrobial... read more

ICU Strain and Mortality Risk Among Critically Ill Patients with COVID-19

The coronavirus disease 2019 (COVID-19) pandemic has affected numerous communities, and reports of overburdened hospitals, specifically critical care units, have become commonplace. High-quality supportive care remains the... read more

Overcoming Enteral Nutrition Delivery Challenges in Critical Care

It is the essential implementation of this new evidence occurs to overcome real and perceived EN challenges. This data should lead to increased standardization/protocolization of ICU nutrition therapy to ensure personalized... read more

Is Cardiopulmonary Resuscitation Futile in COVID-19 Patients Experiencing In-Hospital Cardiac Arrest?

COVID-19 patients suffering from in-hospital cardiac arrest had 100% in-hospital mortality regardless of the baseline comorbidities, presenting illness severity, and location of arrest. Out of 1,094 patients hospitalized... read more

Deep RNA Sequencing of ICU Patients with COVID-19

Current upper respiratory tract testing for COVID-19 only determines if the virus is present. Deep RNA sequencing with appropriate computational biology may provide important prognostic information and point to therapeutic... read more

Why COVID-19 Pneumonia is More Deadly than Typical Pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung within hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or... read more

Critical Care Management of Infectious Meningitis and Encephalitis

Central nervous system (CNS) infections represent 2.9% of the infections encountered in the intensive care unit (ICU). Among them, infectious meningitis and encephalitis, regardless of their community or healthcare-associated... read more

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

Acute brain dysfunction was highly prevalent and prolonged in critically ill patients with COVID-19. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium, and thus these... read more

Adverse Events in the ICU During Bed-Bath Procedures

Serious adverse events were observed in one-half of patients and concerned one-fifth of nurses, confirming the need for caution. Further studies are needed to test systematic serious adverse event prevention strategies. The... read more

Unexpectedly High Frequency of Enterococcal Bloodstream Infections in COVID-19 Patients

Coronavirus disease 2019 seemed to increase the frequency of bloodstream infections (particularly Enterococcus-related bloodstream infection) after ICU admission. This may have been due to enteric involvement in patients... read more