Tag: ICU
Unmasking the Burden: High IAH Prevalence, Associated Morbidity, and Novel Mortality Predictors in Critical Care
This study on 85 critically ill patients revealed a high prevalence of Intra-Abdominal Hypertension (IAH) (54.1%). Key Findings: Primary Contributors: The main factors driving IAH were intravenous (IV) fluid administration... read more
A Critical Curve: Unveiling the U-Shaped Relationship Between the TG/HDL Ratio and All-Cause Mortality in Obese Sepsis
This study analyzed 938 obese sepsis patients to investigate the prognostic significance of lipid metabolism abnormalities, focusing specifically on the Triglyceride-to-HDL (TG/HDL) ratio as a predictor of all-cause mortality. Key... read more
Beyond Creatinine: A Systematic Review of Biomarker Performance (NGAL, KIM-1, TIMP-2·IGFBP7) for Acute Kidney Injury in the ICU
This systematic review analyzed 35 studies to assess the performance of three key Acute Kidney Injury (AKI) biomarkers—NGAL, KIM-1, and TIMP-2 ⋅ IGFBP7—in the Intensive Care Unit (ICU) setting. NGAL (Neutrophil Gelatinase-Associated... read more
Peripheral Perfusion-Targeted Resuscitation Improves Outcomes in Septic Shock
This study, which included 200 sepsis and septic shock patients in the emergency department, compared the effectiveness of management guided by peripheral perfusion measurements against standard care protocols. The study... read more
The Beginner’s Guide to Intensive Care: A Handbook for Junior Doctors and Allied Professionals
Ideal for any medic or health professional embarking upon an intensive care rotation or specialism, this simple bedside handbook provides handy, pragmatic guidance to the day-to-day fundamentals of working in an intensive... read more
Rethinking Blood Pressure Goals: Why High vs. Low MAP Targets Affect Patients with Septic Shock
Based on a study of 776 patients, there's no evidence that different groups of people with septic shock respond differently to a high versus low mean arterial pressure (MAP) target. In other words, there wasn't a "one-size-fits-all"... read more
Reduce Delirium in Critically Ill Patients Using Depth of Sedation Monitors
Delirium impacts up to 80% of patients in the intensive care unit (ICU). Current clinical sedation scales depend on subjective measurements, which are unreliable. We hypothesize processed EEG (pEEG) may be effective at monitoring... read more
Intravenous High-Dose Magnesium for New-Onset Rapid Atrial Fibrillation in the ICU
New-onset atrial fibrillation (AF) is a frequent complication in the intensive care unit (ICU) and is associated with poorer patient outcomes. Despite international guidelines offering limited recommendations, a growing body... read more
The Long-term Impact of nirsevimab on RSV-related Hospitalizations
Following two consecutive RSV seasons, nirsevimab immunization demonstrated significant protection against severe outcomes. The first season showed a substantial reduction in severe disease, and this protective effect continued... read more
Clot Formation Within Tracheostomy Tube in Surgical Unit
Clotting inside tracheostomy tubes is a major problem that can block the airway and trigger breathing problems, more especially among critical care patients. This clinical audit is a full report of the Tracheostomy Care Practice... read more
Hemodynamic and Neurological Presentations of Invasive Meningococcal Disease in Adults
Neurological and hemodynamic presentation of invasive meningococcal disease (IMD) are clinically and prognostically distinct. Recognition of these phenotypes is critical for appropriate management and prediction of outcome. Of... read more
Heterogenous Treatment Effect of Neuromuscular Blocking Agents for Moderate-to-severe ARDS
The systematic and short-term administration of cisatracurium in patients with moderate-to-severe ARDS appears to confer greater survival benefit in those with a higher baseline life expectancy. Further validation through... read more
Meropenem and Piperacillin/Tazobactam Optimized Dosing Regimens for Critically Ill Patients Receiving RRT
This study provides optimized dosing regimens for meropenem and piperacillin/tazobactam in critically ill patients receiving diverse renal replacement therapy (RRT) prescriptions. Daily dosing is dependent on the target... read more
Critical Care Ultrasonography Usage in the Management of Cardiogenic Shock
Despite advancements in treatment, cardiogenic shock (CS) still has a very high mortality rate. To improve patient outcomes, a timely diagnosis and the correct management are crucial. This is especially true given the changing... read more
Endotracheal Intubation Preoxygenation in Resource-limited Settings
Optimal preoxygenation strategies for endotracheal intubation (ETI) in LRS require both protocol adaptation and clinical resourcefulness. An individualized approach using the most feasible combination of techniques should... read more
Increased Driving Pressure During Assisted Ventilation for Hypoxemic Respiratory Failure Is Associated with Lower ICU Survival
Driving pressure is marker of severity and a possible target for lung protection during controlled ventilation, but its value during assisted ventilation is unknown. Inspiratory holds provide an estimate of driving pressure... read more
Airway Management Success in Out-of-hospital Cardiac Arrest Using Different Devices
Although this study found no significant difference in the FPS rates between direct laryngoscopy and video laryngoscopy, the more frequent use of conventional laryngoscopy was associated with a lower FPS rate among anesthetists.... read more
Altered Lower Brainstem Neurophysiological Response Is Associated with Mortality In Deeply Sedated Critically Ill Patients
Absent cough reflex is associated with mortality in intensive care unit (ICU) patients requiring deep sedation, suggesting that lower brainstem dysfunction contributes to adverse outcomes. We conducted a multicenter observational... read more
TBI Management in the ICU
Despite advances in the management of traumatic brain injury (TBI) in the intensive care unit (ICU), and the implementation of new diagnostic techniques and monitoring modalities, the rate of poor neurological outcomes remains... read more
TBI: Quantifying Methodological Uncertainties and Navigating Feasibilities in Monitoring of Cerebral Autoregulation
Traumatic brain injury (TBI) remains a critical medical challenge due to its heterogeneous nature and complex pathophysiological mechanisms. Individualized management of TBI patients, taking advantage of such technologies... read more
Severe Listeriosis in the ICU: Critical Insights from a Multicenter Study
A retrospective multicenter study across 23 French hospitals over 10 years analyzed critically ill ICU patients with culture-confirmed "Listeria monocytogenes" infections. The study aimed to describe patient characteristics,... read more
Seraph-100 Hemoperfusion: Clearing Pathogens and Enhancing Outcomes in Sepsis
This study evaluated Seraph-100 hemoperfusion (HP) as a treatment for sepsis in intensive care unit (ICU) patients admitted after cardiac surgery for infective endocarditis (IE). Thirteen septic patients received Seraph-100... read more
