Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Among critically ill pediatric patients, the use of fresh red blood cells did not reduce the incidence of new or progressive multiple organ dysfunction syndrome (including mortality) compared with standard-issue red blood... read more

Comprehensive Review of Infectious Diseases

Perfect for board review or quick reference in clinical practice, Comprehensive Review of Infectious Diseases is a balanced, high-yield resource covering the full range of infectious disease topics. Whether you're preparing... read more

Comprehensive Review of Infectious Diseases

Wuhan Coronavirus Infections Could Be 30 Times Higher Than Official Total

The number of people infected with a SARS-like form of coronavirus in Wuhan, China could already be more than 30 times higher the the official tally, researchers in Hong Kong have warned. Gabriel Leung, the chair of public... read more

Animal Viruses and Humans, a Narrow Divide: How Lethal Zoonotic Viruses Spill Over and Threaten Us

"To reproduce promiscuously and to wreak havoc wherever they can find a home," this is the sole raison d'être of viruses writes Dr. Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious... read more

Animal Viruses and Humans, a Narrow Divide: How Lethal Zoonotic Viruses Spill Over and Threaten Us

Clinical Features of Patients Infected with Coronavirus in Wuhan, China

A cohort of 41 patients with laboratory-confirmed 2019-nCoV infection. Patients had serious, sometimes fatal, pneumonia and were admitted to the designated hospital in Wuhan, China, by Jan 2, 2020. Clinical presentations... read more

Spillover: Animal Infections and the Next Human Pandemic

The next big human pandemic, the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza, is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event "spillover"... read more

Spillover: Animal Infections and the Next Human Pandemic

The New Coronavirus: What We Do And Don’t Know

A rapidly evolving health story broke in late December when a novel illness originating in Wuhan, China made the news. Reports of the number of infected people swiftly rose, and isolated cases of this new coronavirus —... read more

The Next Pandemic: On the Front Lines Against Humankind’s Gravest Dangers

In this riveting book, Khan tells the dramatic stories of these crises—as well as the stories we don't know—of congo-crimean hemorrhagic fever infecting abattoirs in the United Arab Emirates, as cigarette-smoking local... read more

The Next Pandemic: On the Front Lines Against Humankind’s Gravest Dangers

Superbugs: The Race to Stop an Epidemic

A New York Times bestselling author shares this exhilarating story of cutting-edge science and the race against the clock to find new treatments in the fight against the antibiotic-resistant bacteria known as superbugs. Physician,... read more

Superbugs: The Race to Stop an Epidemic

Neonatal Lung Ultrasonography

This book presents lung ultrasound as an accurate, reliable, low-cost and simple imaging technique, which poses no risk of radiation damage, making bedside use both feasible and convenient in neonatal wards. The aim of... read more

Neonatal Lung Ultrasonography

Coronavirus Can Spread Between Humans

The leader of a Chinese government team of experts announced Monday that human-to-human transmission of a new coronavirus has been confirmed. The finding could raise fears that the infection might not require contact with... read more

Vitamin Treatment For Sepsis Fails In Large Trial

Hope for an effective and inexpensive treatment for the deadly condition sepsis has dimmed following results of a major new study. Researchers had hoped that a simple treatment involving infusions of vitamin C, vitamin... read more

Finding a New Way to Fight Late-stage Sepsis by Boosting Cells’ Antibacterial Properties

Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection. The scientists used nanotechnology... read more

Sepsis Kills Twice as Many People as Experts Feared

Sepsis, which is triggered by an infection, is the cause of 1 in 5 deaths worldwide. It is thought to have killed 47,860 in 2017 - ranking us 45th worst out of 195 countries. Researchers estimate the condition claimed... read more

Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus Aureus Bacteremia

The results of this study further support the importance of prompt appropriate antibiotic administration for patients with septic shock. Physicians should consider acting quickly to administer antibiotics with S. aureus... read more

Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery

Preoperative vitamin D was not associated with a composite of postoperative 30-day cardiac outcomes. However, there was a significant association between vitamin D deficiency and a composite of infectious complications and... read more

Improving Community Recognition of Sepsis Using Early Warning Scores

Introducing a community version of National Early Warning Score (NEWS) to clinical assessments in acute clinical care has shown benefits for both patients and staff, and could be disseminated to all community services across... read more

Serum Protein Changes in Pediatric Sepsis Patients Identified with an Aptamer-Based Multiplexed Proteomic Approach

The serum protein changes identified with the aptamer-based multiplexed proteomics approach used in this study can be useful to distinguish between sepsis and noninfectious systemic inflammation. A cohort of 40 children... read more

Endogenous Agmatine Metabolism Correlated with the Progression of Sepsis

Supplemental exogenous agmatine could ameliorate the lipopolysaccharide-induced systemic inflammatory responses and multiple organ injuries through the 2 receptor">imidazoline I2 receptor-ribosomal S6 kinase 2-nuclear factor-κB... read more

Cannula and Circuit Management in Peripheral ECMO

Variable practices regarding extracorporeal membrane oxygenation (ECMO) line management exist worldwide based on recommendations lacking specific ECMO content and context. This survey identified evidence gaps regarding... read more

Optimal Duration of Mechanical Ventilation and Influencing Factors Following Mandibular Distraction Osteogenesis in Infants

Mandibular distraction osteogenesis (MDO) is an effective treatment for tongue-based airway obstruction in infants with severe Pierre Robin sequence (PRS). Most infants receiving MDO require postoperative mechanical ventilation... read more

Impaired Cerebral Auto-regulation is Associated with Brain Dysfunction in Patients with Sepsis

Cerebral auto-regulation was altered in half of the patients with sepsis and was associated with the development of SABD. These findings support the concept that cerebral hypoxia could contribute to the development of... read more