Surfactant Therapies for Pediatric ARDS

Surfactant Therapies for Pediatric ARDS

We advocate for well-designed preclinical and explanatory clinical studies to investigate the use of surfactant for pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome. Given the accumulating knowledge... read more

The Mysterious Vanishing of MIS-C

The Mysterious Vanishing of MIS-C

Whilst the overwhelming majority of Covid-19 infections in healthy children are mild or asymptomatic, the serious risk which remained was of the hyperinflammatory syndrome known as MIS-C (Multi-system Inflammatory Syndrome... read more

Inflammation Causes COVID-19-related Loss of Smell Not The Virus

Inflammation Causes COVID-19-related Loss of Smell Not The Virus

This study found that COVID-19 infection is associated with axon injuries and microvasculopathy in olfactory tissue. The striking axonal pathology in some cases indicates that olfactory dysfunction in COVID-19 infection may... read more

Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia

Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia

Airway infection is a major cause of mortality worldwide. The identification of new mechanisms aiding in effective host immune response is therefore required. Here, we show that the specific depletion of the pleural immune... read more

tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?

tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?

How do you define a last-ditch effort to save someone's life from COVID-19? Perhaps giving tPA to a severe COVID patient? At this point, I am certain many of us have attempted, with informed consent of course, therapies for... read more

Thromboinflammation and Antithrombotics in COVID-19

Thromboinflammation and Antithrombotics in COVID-19

Thrombotic complications of SARS-CoV-2 infection were recognized early in the pandemic, when infected patients often presented with abnormal coagulation findings and acute macrovascular obstruction, and evidence of pulmonary... read more

Vasopressor Choice and Timing in Vasodilatory Shock

Vasopressor Choice and Timing in Vasodilatory Shock

Vasodilatory shock is the most common form of circulatory shock encountered in patients admitted to the intensive care unit (ICU). Sepsis is the predominant etiology, but other causes of vasodilatory shock include postoperative... read more

Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients

Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients

Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32)... read more

Obstructive Airway Diseases: Role of Lipid Mediators

Obstructive Airway Diseases: Role of Lipid Mediators

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is... read more

Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema

Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema

This study compared the effect of placebo versus the bradykinin B2 receptor antagonist icatibant on symptoms of ACE inhibitor–associated angioedema in a mixed race population of patients. The study does not support the... read more

Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis

Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis

Bacterial sepsis patients had early, severe inflammation, profound immune suppression, and life-threatening organ dysfunction that resolved over time; SARS-CoV-2 patients had less severe early inflammation and organ dysfunction... read more

Predicting Sepsis Severity at First Clinical Presentation

Predicting Sepsis Severity at First Clinical Presentation

The severity and endotype signatures indicate that distinct immune signatures precede the onset of severe sepsis and lethality, providing a method to triage early sepsis patients. Gene expression signatures were obtained... read more

Critical COVID-19 Pneumonia Determinants

Critical COVID-19 Pneumonia Determinants

SARS-CoV-2 infection is benign in most individuals but, in approx. 10% of cases, it triggers hypoxemic COVID-19 pneumonia, which becomes critical in ˜3% of cases. The ensuing risk of death (˜1%) doubles every five years... read more

Postoperative Critical Care for Adult Cardiac Surgical Patients

Postoperative Critical Care for Adult Cardiac Surgical Patients

This text reviews the postoperative management of patients who have undergone cardiac surgical procedures, some of the most common and most complicated forms of surgery. These patients and their management are characterized... read more