Tag: inflammation
Fluid Management Impact on Outcomes in Sequential Extracorporeal Support
Sepsis is a life-threatening condition characterized by dysregulated inflammatory responses, often leading to multiple organ dysfunction and high mortality rates. Continuous renal replacement therapy (CRRT) and extracorporeal... read more
Leptin and Linterlukin-6 Relationship and Influence of Mortality in Sepsis
High leptin levels might counteract the adverse prognostic effect of elevated IL-6 on septic mortality. At the same IL-6 level, leptin could predict septic mortality. Leptin might be a protecting factor for men and gender-different... read more
Predicting Sudden Decrease in Oxygenation in Mechanically Ventilated ICU Patients as a Surrogate Marker for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening form of respiratory failure characterized by widespread lung inflammation that severely impairs oxygenation. Affecting millions of patients worldwide, ARDS... read more
Unlocking the Predictive Power of Nutritional Scores in Septic Patients
The study highlights the mNUTRIC score's practicality and reliability in assessing nutritional and inflammatory risks in septic patients, particularly in non-ICU settings. These findings suggest its potential utility... read more
VEGFR1 Genetic Regulation During Sepsis and Association with ARDS Susceptibility
We identified biologically relevant protein quantitative trait loci (pQTLs) of vascular endothelial growth factor receptor 1 (VEGFR1) levels during sepsis in TCF20 and identified CYP2D6 as the gene more biologically implicated.... read more
Cytokeratin-18 Levels in COVID-19 Patients
This study analyzed 176 samples, including 63 ICU-admitted patients and 88 non-ICU-admitted patients. A substantial difference was found between the AST and CK-18 levels of the patients receiving ICU care and those who did... read more
Prognostic Value of Composite Inflammatory Markers in COPD Patients
Elevated systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), pan-immune inflammation value (PIV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are associated... read more
Using Critical Ultrasound To Predict Early Diagnosis of ICU-acquired Weakness in Septic Patients
This study uncovered pivotal indicators for predicting the occurrence of ICUAW in septic patients. Despite no significant difference in age, gender, BMI, BSA, or SOFA scores between the two groups, the significant differences... read more
Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection
The interplay of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and Clostridioides difficile infection (CDI) poses a critical clinical challenge. The resultant inflammatory milieu and its impact... read more
Fluid Bolus Therapy with 20% Albumin vs. Crystalloid-based Regimen
In this trial involving adult patients undergoing cardiac surgery with cardiopulmonary bypass, 20% albumin fluid bolus therapy (FBT) compared to crystalloid FBT did not decrease the occurrence of acute kidney injury (AKI).... read more
Sepsis Patients with Disseminated Intravascular Coagulation
Sepsis is a life-threatening organ dysfunction caused by dysregulation of the body's response to infection, and is one of the leading causes of death in intensive care units. In sepsis, the systemic inflammatory reaction... read more
Evaluation Effects of Nebulized Hypertonic Saline and Nebulized Corticosteroids in Patients with ARDS
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute respiratory failure as a result of diffuse lung inflammation and oedema manifested by hypoxemia and stiffness in the lungs. This study... read more
Personalized Therapies in ARDS
Acute respiratory distress syndrome (ARDS) can result from a variety of clinical conditions, causing lung injury either directly through local inflammation or indirectly because of systemic inflammatory mediators ARDS is... read more
Relationship between Concentrations of Oxygen and Levels of Oxidative Stress in Patients Receiving Oxygen Therapy for Severe COVID-19 Pneumonia
We evaluated the potential of high-flow oxygen therapy to increase oxidative stress and inflammation in COVID-19 patients. Our observation of decreased MDA levels when transitioning hypertensive patients from high-flow to... read more
Outcomes and inflammation changes in different types of immunocompromised patients with critically ill COVID-19 admitted to ICU
Critically ill COVID-19 patients admitted to the ICU exhibit distinct clinical outcomes based on their immunosuppression status, with cancer patients facing the highest mortality rate due to variations in inflammatory responses... read more
Distinct Immune Profiles and Clinical Outcomes in Sepsis Subphenotypes Based on Temperature Trajectories
Sepsis subphenotypes identified using the universally available measurement of body temperature had distinct immune profiles. Hypothermic patients, who had the highest mortality rate, also had the lowest levels of most pro-... read more
COVID-19 Pneumonia: Different Respiratory Treatments for Different Phenotypes?
Type L and Type H patients are best identified by CT scan and are affected by different pathophysiological mechanisms. If not available, signs which are implicit in Type L and Type H definition could be used as surrogates:... read more
Disease Progression Associated Cytokines in COVID-19 Patients with Deteriorating and Recovering Health Conditions
Understanding the immune response to COVID-19 is challenging due to its high variability among individuals. To identify differentially expressed cytokines between the deteriorating and recovering phases, we analyzed the Electronic... read more
Army Scientists’ Technique for Early Sepsis Detection in Burn Patients Submitted to FDA
A new invention developed at the U.S. Army Medical Research and Development Command uses an artificial intelligence machine learning algorithm to identify whether burn patients are at risk of experiencing life-threatening... read more
Corticosteroid Treatment and Survival in Critically Ill COVID-19 Patients
Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid... read more
Hematological, Inflammatory and Serological Responses Among COVID-19 ICU Patients
A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission. Significant... read more
Glucose Metabolism Disorders: Pre-hospital Oxygen Therapy and Saturation Variability in COVID-19 Patients
The COVID-19 pandemic has revealed that viruses can have multiple receptor properties, penetrating various tissues and causing mutations in various genes, thus promoting a range of metabolic disorders. The purpose of... read more
