Tag: mortality
COVID-19-related Death in Fully Vaccinated People in Scotland – Characteristics and Risk
Vaccines are highly effective in preventing COVID-19 hospitalisations and deaths. COVID-19-related deaths in fully vaccinated individuals have, however, been reported. To inform public health strategy and vaccination... read more
The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks
Our data suggest that the sepsis risk stratification tools currently utilized in emergency departments and on the general wards do not predict mortality adequately. This is illustrated by the disparity in mortality risk... read more
Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest
In comatose survivors of out-of-hospital cardiac arrest, a target temperature of 31 °C did not significantly reduce the rate of death or poor neurologic outcome at 180 days compared with a target temperature of 34 °C. However,... read more
Time Course of Risk Factors Associated with COVID-19 Mortality
The present multicentric study describes 1,260 critically ill patients with COVID-19-associated acute respiratory failure consecutively admitted to 24 Italian ICUs during the first pandemic wave. This study specifically... read more
COVID-19 Surges Increased Patient Mortality
A recent study by scientists at the National Institutes of Health suggests that one in every four COVID-19 deaths in the United States may be attributed to hospitals strained by surging caseloads. Published in the Annals... read more
Effects of 5% Albumin Plus Saline vs. Saline Alone on Outcomes From Large-Volume Resuscitation in Critically Ill Patients
During large-volume resuscitation, 5% albumin was associated with reduced mortality and major adverse kidney event at 30, 90, and 365 days. However, a higher rate of acute kidney injury of any stage was observed that did... read more
Evolving Changes in Mortality of Critically Ill with COVID-19 Over 8 Months
Age and mortality rates have declined over the first 8 months of the pandemic. The use of non-invasive respiratory support (NIRS) as the first respiratory support measure was associated with survival, but causal inference... read more
Protecting The Injured RV in COVID-19 ARDS
The abnormal interaction between the right ventricle (RV) and pulmonary vasculature in various disease states is associated with adverse clinical outcomes. Impaired RV physiology in acute respiratory distress syndrome (ARDS)... read more
Tocilizumab Use May Be Associated with a Short-term Mortality Benefit
For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required. Its benefits may also lie in reducing the... read more
Severity of Hypoxemia may Explain Indeterminate Results in Pediatric Trials of iNO
Inhaled nitric oxide (iNO) is used for refractory hypoxemia in acute respiratory distress syndrome (ARDS) via vasodilation of pulmonary arterioles to ventilated alveoli, particularly in pediatrics. However, iNO has not affected... read more
Major Trauma Definition Using Different Revisions of the Abbreviated Injury Scale
Injury Severity Score (ISS) 08 ≥ 11 and ISS 15 ≥ 12 perform similarly to a threshold ISS 98 ≥ 16 for in-hospital mortality and ICU admission. This confirms studies evaluating mapped datasets, and is the... read more
d-dimer and Death in COVID-19 Patients
In this multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs across the United States, higher d-dimer was independently associated with a greater risk of death. The added value of d-dimer in... read more
Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients
In a cohort of critically ill patients with a high prevalence of thromboembolic events, ET was associated with reduced ICU mortality without an increased burden of haemorrhagic complications. This study suggests ET strategies... read more
Precision Medicine in ARDS
Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for... read more
Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes
This study suggests that β-blocker exposure prior to sepsis, especially to noncardioselective β blockers, may be associated with better outcome. The findings suggest prospective evaluation of β-blocker use in the management... read more
Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults
In this study, low baseline diaphragm muscle mass in critically ill patients was associated with prolonged mechanical ventilation, complications of acute respiratory failure, and an increased risk of death in the hospital. A... read more
90 Day Outcomes of COVID-19 Patients in European ICUs
This communication delineates outcomes in COVID-19 patients in the context of ARDS severity, ventilatory management, and variables associated with mortality on a 90-day follow-up for subgroups of patients after ICU admission.... read more
Sunlight Linked to Lower COVID-19 Deaths
Our analysis suggests that higher ambient UVA exposure is associated with lower COVID‐19 specific mortality. Further research on the mechanism may indicate novel treatments. Optimised UVA exposure may have population health... read more
