Tag: mortality
Galectin-3 in Septic AKI
This translational study demonstrates the importance of Gal-3 in the pathogenesis of sepsis acute kidney injury (S-AKI), and its potential utility as a therapeutic target. In 57 patients admitted to the intensive care... read more
Increased risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1
We started estimating the SARS-CoV-2 reproduction number in the UK using Public Health England data in March 2020, contributing to the Scientific Pandemic Influenza Modelling subgroup (SPI-M) weekly consensus estimates. In... read more
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial
In critically ill mechanically ventilated patients, early sedation with dexmedetomidine exhibited a high probability of reduced 90-day mortality in older patients regardless of operative or non-operative cluster status. Conversely,... read more
Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation
Among patients with unhealthy alcohol use receiving mechanical ventilation, treatment with high-dose baclofen, compared with placebo, resulted in a statistically significant reduction in agitation-related events. The primary... read more
Antiviral Drugs in Hospitalised COVID-19 Patients
These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital... read more
The Association of Platelet Decrease Following CRRT Initiation and Increased Rates of Secondary Infections
Platelet count drop by greater than 40% following continuous renal replacement therapy (CRRT) initiation is associated with an increased risk of secondary infection, particularly in patients with thrombocytopenia at the time... read more
Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19
Treatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence... read more
Management of Neonates With Tetralogy of Fallot
What are the differences in outcomes between a strategy of staged repair (SR) (initial palliation [IP] and subsequent complete repair [CR]) as compared with primary repair (PR) for infants with symptomatic tetralogy of Fallot... read more
SOFA Score Accuracy For Determining Mortality Of Severely Ill Patients With COVID-19 Pneumonia
The SOFA score possesses inadequate discriminant accuracy to be used for ventilator triage of COVID-19 patients. A better option is needed that incorporates variables specifically related to mortality in patients with COVID-19... read more
Retrospective validation of a risk stratification tool developed for the management of patients with blunt chest trauma
The STUMBL score at a cut‐off of 15 predicted prolonged LOS and a score >18 predicted mortality sufficiently to be clinically useful for these outcomes. The STUMBL Score is composed of five simple predictors; patient... read more
Insight into ECMO, mortality and ARDS
ARDS is a severe disease with a high mortality rate despite ECLS therapy. Although endpoints and timing of the evaluations differed from those of the CESAR and EOLIA studies and the Extracorporeal Life Support Organization... read more
Haloperidol, Clonidine and Resolution of Delirium in Critically Ill Patients
Haloperidol and clonidine use in delirious ICU patients may be associated with reduced probability of delirium resolution. This finding, however, merits further investigation given inherent limitations of this observational... read more
Mediastinal lymphadenopathy may predict 30-day mortality in COVID-19 patients
Along with older age and consolidation pattern,enlarged mediastinal lymphadenopathy was found to be an independent predictor of 30-day mortality in patients with COVID-19. Although enlarged mediastinal lymphadenopathy... read more
Prediction Model for Severe CAP among Patients with Diabetes Mellitus
Diabetes is an independent risk factor for the development of severe community-acquired pneumonia (CAP) and associated with pneumonia-related hospitalization as well as mortality. Here, we assessed several selected biomarkers... read more
