A Dedicated VV-ECMO Unit during a Respiratory Pandemic

A Dedicated VV-ECMO Unit during a Respiratory Pandemic

Background: The most critically ill patients with coronavirus disease 2019 (COVID-19) may require advanced support modalities, such as veno-venous extracorporeal membrane oxygenation (VV-ECMO). A systematic, methodical approach... read more

The Practice and Principles of Extra-Corporeal Membrane Oxygenation (ECMO)

The Practice and Principles of Extra-Corporeal Membrane Oxygenation (ECMO)

As demonstrated in the first book, the management of patients with profound respiratory failure or cardiogenic shock has evolved significantly over the years with advances in diagnostic and therapeutic options. While the... read more

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

COVID-19: Dual Oxygen Concentrator System for Mechanical Ventilation

Sabah in Malaysian Borneo is among the Malaysian states which reported a high number of detected COVID-19 cases during the current pandemic. Due to geographical challenges and limited resources, clinicians developed novel... read more

Prone Positioning in Spontaneously Breathing Subjects With Moderate or Severe ARDS During Invasive Ventilation

Prone Positioning in Spontaneously Breathing Subjects With Moderate or Severe ARDS During Invasive Ventilation

In a retrospective analysis of consecutive intubated subjects with moderate or severe ARDS, related or not to COVID-19, spontaneous breathing during prone positioning (PP) was well tolerated and achieved significant improvement... read more

Prone Positioning of Nonintubated Patients with COVID-19

Prone Positioning of Nonintubated Patients with COVID-19

Despite the significant variability in frequency and duration of prone positioning and respiratory supports applied, prone positioning was associated with improvement in oxygenation variables without any reported serious... read more

Cerebral Oxygen Saturation and Autoregulation During Hypotension in Extremely Preterm Infants

Cerebral Oxygen Saturation and Autoregulation During Hypotension in Extremely Preterm Infants

Dopamine had no effect on rScO2 compared to placebo in hypotensive infants. Hypotension and cerebral hypoxia are associated with early intraventricular hemorrhage or death. Prospective cohort study of blinded rScO2 measurements... read more

Expiratory Flow Limitation During Mechanical Ventilation

Expiratory Flow Limitation During Mechanical Ventilation

Expiratory flow limitation (EFL) is present when the flow cannot rise despite an increase in the expiratory driving pressure. The mechanisms of EFL are debated but are believed to be related to the collapsibility of small... read more

Escalation and Withdrawal of Treatment for Patients on ECMO

Escalation and Withdrawal of Treatment for Patients on ECMO

Discussion between clinicians and families about prognosis and goals was frequent but did not occasion decision-making moments. This study helps explain why communication interventions intended to maintain patient autonomy... read more

Operative Techniques and Recent Advances in Acute Care and Emergency Surgery

Operative Techniques and Recent Advances in Acute Care and Emergency Surgery

The aim of this book is to identify and shed new light on the main surgical practices involved in acute care and trauma surgery. Adopting an evidence-based approach, a multidisciplinary team of surgeons and intensivists... read more

Relationship Between Skeletal Muscle Area and Density and Clinical Outcome in Adults Receiving VV-ECMO

Relationship Between Skeletal Muscle Area and Density and Clinical Outcome in Adults Receiving VV-ECMO

Low skeletal muscle index at the commencement of venovenous extracorporeal membrane oxygenation (VV-ECMO) was associated with a longer duration of venovenous extracorporeal membrane oxygenation, whereas preserved skeletal... read more

Left Ventricular Unloading and ECpella Role

Left Ventricular Unloading and ECpella Role

The main reason for the emergency implantation of venoarterial extracorporeal membrane oxygenation (VA-ECMO) is the restoration of adequate systemic perfusion, while protecting the failing heart and promoting myocardial recovery... read more

Effects of Ventilatory Rescue Therapies on the Cerebral Oxygenation of COVID-19 Patients

Effects of Ventilatory Rescue Therapies on the Cerebral Oxygenation of COVID-19 Patients

A new study by Masimo published in Critical Care evaluated the impact of a variety of rescue therapies on the systemic and cerebral oxygenation of mechanically ventilated COVID-19 patients suffering from acute respiratory... read more

Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients

Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients

In this observational study of intubation practices in critically ill patients from a convenience sample of 197 sites across 29 countries, major adverse peri-intubation events—in particular cardiovascular instability—were... read more

Improving Outcomes for Children Requiring ECMO Therapy Following Hematopoietic Stem Cell Transplantation

Improving Outcomes for Children Requiring ECMO Therapy Following Hematopoietic Stem Cell Transplantation

Pediatric patients posthematopoietic stem cell transplantation supported with extracorporeal membrane oxygenation have improving survival rates over time. With 26% of patients (16/62) surviving to hospital discharge in the... read more

Effect of Intermediate-Dose vs. Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, ECMO Treatment, or Mortality Among Patients With COVID-19 in ICU

Effect of Intermediate-Dose vs. Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, ECMO Treatment, or Mortality Among Patients With COVID-19 in ICU

Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome... read more

Timing of Intubation in Patients With COVID-19

Timing of Intubation in Patients With COVID-19

The timing of intubation in hypoxemic patients with COVID-19 has been hotly debated. Early in the pandemic, there was a push to intubate early, driven by the effort to reduce transmission of the virus. With time, high-flow... read more

Monitoring tissue oxygenation index using near‐infrared spectroscopy during pre‐hospital resuscitation

Monitoring tissue oxygenation index using near‐infrared spectroscopy during pre‐hospital resuscitation

In this pilot study, we demonstrated the feasibility of ∆TOI as a dynamic value rather than single static value among OHCA patients in a pre-hospital setting. ∆TOI can be considered as a predictor of return of spontaneous... read more