Mechanical Ventilators for Non-invasive Ventilation

Mechanical Ventilators for Non-invasive Ventilation

This book analyzes and describes the whole spectrum of technical elements related with non-invasive mechanical ventilators technologies, ventilator modes and complementary technologies for correct interpretation and clinical... read more

Effect of Tocilizumab vs. Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia

Effect of Tocilizumab vs. Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia

The administration of tocilizumab in patients with COVID-19 pneumonia and a Pao2/Fio2 ratio between 200 and 300 mm Hg did not reduce the risk of clinical worsening. Further blinded, placebo-controlled randomized clinical... read more

Some Signs of Recovery From Severe COVID-19 Lung Damage

Some Signs of Recovery From Severe COVID-19 Lung Damage

In two early studies, researchers said some patients showed signs of healing just weeks after leaving the hospital. Lingering shortness of breath and diminished stamina have dogged many COVID patients whose lungs were... read more

Synthesis and Systematic Review of Reported Neonatal COVID-19 Infections

Synthesis and Systematic Review of Reported Neonatal COVID-19 Infections

A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present... read more

VTE and COVID-19: Would you like to know more?

Who wouldn't want to know more about a disease that has killed >1 million people to date, worldwide. Who wouldn't want to know more about the thromboembolic risk associated with COVID-19 when we have been told that the VTE... read more

Bacterial Profile of Ventilator Associated Pneumonia: Concept, Review, Methods, Observations, Inference

Bacterial Profile of Ventilator Associated Pneumonia: Concept, Review, Methods, Observations, Inference

ICU is a hotbed of infections and measures are taken to prevent these infections. Ventilator associated pneumonia is one of the Intensive Care Unit related infections. This book tells us what ventilator associated pneumonia... read more

Awake Prone Positioning for COVID-19 Hypoxemic Respiratory Failure

Awake Prone Positioning for COVID-19 Hypoxemic Respiratory Failure

Infection with SARS-CoV-2 can result in Coronavirus Disease–19 (COVID-19). While the majority of patients are asymptomatic or have mild disease, approximately 14% develop more severe disease including hypoxemic respiratory... read more

Anaphylatoxin C5a Impairs Phagocytosis by Neutrophils

Anaphylatoxin C5a Impairs Phagocytosis by Neutrophils

This study provides new insight into the mechanisms underlying immunocompromise in critical illness and suggests novel avenues for therapy and prevention of nosocomial infection. Critically ill patients are at heightened... read more

POCUS is Having Its Moment

POCUS is Having Its Moment

Ultrasound performed at the point of care (POCUS) is having its moment. The COVID-19 pandemic has seemingly caused the acceleration of POCUS acceptance by hospital leaders, and POCUS examinations are increasingly performed... read more

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Approximately two-thirds of patients admitted to the intensive care unit (ICU) for coronavirus disease-19 (COVID-19) pneumonia present with the acute respiratory distress syndrome (ARDS). COVID-19-associated acute cardiac... read more

Hydrocortisone Prevents Immunosuppression by interleukin-10+ Natural Killer Cells After Trauma-Hemorrhage

Hydrocortisone Prevents Immunosuppression by interleukin-10+ Natural Killer Cells After Trauma-Hemorrhage

These data demonstrate that trauma-induced immunosuppression is characterized by an interleukin-10-dependent elimination of dendritic cell by natural killer cells and that hydrocortisone improves outcome by limiting this... read more

Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients

Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients

Humanigen, the clinical stage biopharmaceutical company focused on preventing and treating cytokine storm, has reported positive data from the first clinical use of lenzilumab, its humaneered anti-human granulocyte macrophage-colony... read more

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more

A Mass Casualty In Slow Motion: Emergency Medicine During the COVID-19 Surge in New York City

A Mass Casualty In Slow Motion: Emergency Medicine During the COVID-19 Surge in New York City

The first time I really took notice of coronavirus was when a few providers started wearing masks during their shifts. This was in mid-February when the virus was a Wuhan problem, and we were screening people with travel... read more