Handbook of Drugs in Intensive Care: An A-Z Guide

Handbook of Drugs in Intensive Care: An A-Z Guide

Now in its sixth edition, the Handbook of Drugs in Intensive Care is the essential guide to using drugs safely and effectively in the intensive care setting. The book is split into two sections: an A-Z guide to the drugs... read more

The developing kidney: Perinatal aspects and relevance throughout life

The developing kidney: Perinatal aspects and relevance throughout life

Human perinatal nephrology is a very diverse field in medicine, shared—among others—between obstetricians, neonatologists and nephrologists. Extremely low birth weight infants, babies with growth restriction, and specific... read more

The Association of Platelet Decrease Following CRRT Initiation and Increased Rates of Secondary Infections

The Association of Platelet Decrease Following CRRT Initiation and Increased Rates of Secondary Infections

Platelet count drop by greater than 40% following continuous renal replacement therapy (CRRT) initiation is associated with an increased risk of secondary infection, particularly in patients with thrombocytopenia at the time... read more

Pharyngeal abscess: a rare complication of repeated nasopharyngeal swabs

Pharyngeal abscess: a rare complication of repeated nasopharyngeal swabs

A 73-year-old end-stage renal disease patient who had undergone craniopharyngioma resection 30 years previously was admitted to hospital after a fall. He developed hospital-acquired laboratory-confirmed SARS-CoV-2 that required... read more

De Novo Renal Failure and Clinical Outcomes of Patients With Critical COVID-19

De Novo Renal Failure and Clinical Outcomes of Patients With Critical COVID-19

This case series concludes that respiratory failure conveys significant mortality risk in patients with coronavirus disease 2019 and that survival with concomitant renal failure is rare. This is a case series of patients... read more

Cardiothoracic Critical Care

Cardiothoracic Critical Care

This new bedside manual guides you through all the practical aspects of managing patients following cardiothoracic surgery and critically ill cardiology patients. Primarily designed to use in cardiothoracic intensive care... read more

Perioperative Management of Glucose-lowering Drugs in Type 2 Diabetes Patients

Perioperative Management of Glucose-lowering Drugs in Type 2 Diabetes Patients

Patients with type 2 diabetes are commonly referred for elective or emergency surgery. In case of scheduled surgical procedures, previous guidelines recommended to withhold oral glucose-lowering drugs. Based on recent... read more

AKI in Critically Ill Patients with COVID-19

AKI in Critically Ill Patients with COVID-19

Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting,... read more

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more

Unfractionated Heparin (UFH), LMWH, Fondaparinux, Argatroban, and Bivalirudin

Unfractionated Heparin (UFH), LMWH, Fondaparinux, Argatroban, and Bivalirudin

Unfractionated heparin (UFH) binds to anti-thrombin III (AT-III), which enhances antithrombin's inhibition of several coagulation factors – especially factor Xa and factor IIa (thrombin). Low Molecular-Weight Heparin... read more

Effects of Paracentesis on Hemodynamic Parameters and Respiratory Function in Critically Ill Patients

Effects of Paracentesis on Hemodynamic Parameters and Respiratory Function in Critically Ill Patients

Paracentesis in critically ill patients is safe regarding hemodynamic function, renal function and intervention-related complications. Furthermore, paracentesis in critically ill and mechanically ventilated patients results... read more

Renal Function-Adjusted D-Dimer Levels in Critically Ill Patients With Suspected Thromboembolism

Renal Function-Adjusted D-Dimer Levels in Critically Ill Patients With Suspected Thromboembolism

D-Dimer cutoff levels adjusted for renal dysfunction appear feasible and safe assessing thromboembolic disease in critically ill patients. Furthermore, adjusted D-dimer cutoff levels seem reliable in patients with acute kidney... read more

Low-dose vs. High-dose Magnesium in Rapid Afib

Low-dose vs. High-dose Magnesium in Rapid Afib

Magnesium sulfate has been used as an adjunct medication for the treatment of atrial fibrillation (AF) due to its ability to lessen sinus node depolarization via calcium antagonism. Prior studies investigating magnesium in... read more

IV Fluids and Solutions Quick Reference Guide Cheat Sheet

IV Fluids and Solutions Quick Reference Guide Cheat Sheet

Intravenous solutions are used in fluid replacement therapy by changing the composition of the serum by adding fluids and electrolytes. Quick reference guide on the different intravenous solutions.... read more

Acute Kidney Injury is not Associated with IV Contrast Use in the ED

Acute Kidney Injury is not Associated with IV Contrast Use in the ED

Intravenous (IV) iodinated contrast media is used routinely to improve the accuracy of computed tomography (CT) in the emergency department (ED).  Prior studies have linked contrast media with the development of acute kidney... read more

Vasopressin vs. norepinephrine for vasoplegic shock after cardiac surgery

Vasopressin vs. norepinephrine for vasoplegic shock after cardiac surgery

Patients in the VANISH trial treated with vasopressin had a lower incidence of renal failure requiring hemodialysis. However, this was a secondary endpoint which seemed to contradict the primary endpoint (defined as a milder... read more