Tag: sepsis
Effect of Adjunctive Vitamin C, Glucocorticoids, and Vitamin B1 on Sepsis
We aimed to compare the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock. MEDLINE, Embase, CENTRAL, ClinicalTrials.gov... read more
Can Early Cytokine Profile Discriminate Between GPB and GNB?
Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive... read more
Difference in Sepsis Patients Outcomes Between First and Second-Hit Infections
Our study identifies a fundamental difference in patient outcomes between first-hit and second-hit bacterial infections, which may be due to genetic, microbiological, immunological, and environmental factors. This finding... read more
Multicomponent Sepsis Transition Effect and Recovery Program After Sepsis
In a multisite randomized clinical trial of patients hospitalized with sepsis, patients provided with a 30-day program using a nurse navigator to provide best practices for postsepsis care experienced a lower proportion of... read more
ARDS vs. PseudoARDS – Failure of the Berlin Definition
True ARDS might be defined as a histological diagnosis involving diffuse alveolar damage throughout the lungs (characterized by hyaline membrane formation and thickening of the alveolar walls). PseudoARDS refers to patients... read more
The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks
Our data suggest that the sepsis risk stratification tools currently utilized in emergency departments and on the general wards do not predict mortality adequately. This is illustrated by the disparity in mortality risk... read more
Emerging Advances have the Potential to Change the Future of Sepsis Care
In recent years, many advances in the sepsis literature have occurred, including new definitions, changes to the Surviving Sepsis Campaign (SSC) bundles, new pharmacologic agents, and adjunct treatments. There are also... read more
Timing of Antibiotic Therapy in the ICU
Severe or life threatening infections are common among patients in the intensive care unit (ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial therapy for clinical resolution. Antibiotics... read more
Epidemiology of Intravenous Immune Globulin in Septic Shock
Intravenous immune globulin is used infrequently across the US in patients with septic shock. Regimens of IVIG in septic shock may be less intensive than those associated with a survival benefit in meta-analyses. Observed... read more
Higher ICU Sepsis Case Volume Associated with Significantly Lower Hospital Mortality
In this cohort study of 273,001 patients with sepsis at 231 ICUs in the UK, a higher annual sepsis case volume in the ICU was associated with significantly lower hospital mortality, and this association had no significant... read more
The Gut in COVID‑19
In the last year, a growing number of articles addressed coronavirus disease 2019 (COVID-19), including its link with gastrointestinal (GI) (dys)function. We here highlight the most important findings regarding the role of... read more
Sepsis: Clinical Diagnosis and Treatment
Sometimes our body's reaction to infection can result in damage to internal tissues and organs. Such a condition is referred to as sepsis. Some of the symptoms of sepsis are high fever, increased heart and breathing rate,... read more
Reducing the Global Sepsis Burden: A Positive Legacy for the COVID-19 Pandemic?
ESICM, SCCM, and the GSA published a consensus paper in Intensive Care Medicine, emphasising the importance of recognising that patients critically ill with COVID-19 have viral sepsis, despite some differences from sepsis... read more
Lactate = LactHATE
Like many others who attended SMACC earlier this year I returned home dazed and confused about the significance of lactate in the septic patient. So like any good (aspiring to be) evidence-based medicine practitioner,... read more
Sepsis Subclasses: A Framework for Development and Interpretation
Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based... read more
Sevoflurane in Murine Peritonitis-induced Sepsis
Sevoflurane exerts various protective effects in two murine peritonitis-induced sepsis models. These protective effects were linked with a functional adenosine A2B receptor. Sevoflurane reduced the neutrophil counts in... read more
Oral Midodrine Feasibility in Early Sepsis
This study proved the feasibility of clinical trial to use oral midodrine in early sepsis. The study was not powered to detect statistically significant differences between the two groups, and therefore, the results from... read more
