Tag: SOFA

Managing Recurrent Septic Shock – Dual Blood Purification with CytoSorb and oXiris

This case report presents a patient with recurrent septic shock who experienced significant clinical improvement after receiving adjunctive treatment with a combination of continuous renal replacement therapy (CRRT) using... read more

Cellular Therapy with Mesenchymal Stromal Cells in Sepsis

Cellular therapy with mesenchymal stromal cells (MSCs) is a promising therapeutic modality in sepsis. Positive effects are mainly associated with frequent infusions and the dose of 1 × 106 cell/kg. Larger scale studies... read more

Association Between Early Ondansetron Use and Sepsis Risk in ICU Patients

In both patients with SOFA 3, early ondansetron use was correlated with a reduced risk of sepsis. Patients with early ondansetron use had lower odds of experiencing sepsis than patients without early ondansetron use, which... read more

Predicting Sepsis Outcomes – Efficacy of Early Warning Scores

In resource-limited settings, NEWS proved to be the most effective tool for early risk stratification in sepsis patients. Its adoption could significantly enhance sepsis management and improve outcomes in emergency departments... read more

Using Critical Ultrasound To Predict Early Diagnosis of ICU-acquired Weakness in Septic Patients

This study uncovered pivotal indicators for predicting the occurrence of ICUAW in septic patients. Despite no significant difference in age, gender, BMI, BSA, or SOFA scores between the two groups, the significant differences... read more

Developing a Rapid Screening Tool for High-risk ICU Sepsis Patients

This study demonstrates that machine learning-based prediction models for sepsis can enhance clinical outcomes through accurate risk assessment during the critical first 24h of ICU admission. Despite healthcare system... read more

Establishment and Validation of a Risk Prediction Model for Sepsis-Associated Liver Injury in ICU Patients

This novel nomogram effectively predicts SALI risk in sepsis patients by integrating readily available clinical parameters. While external validation is needed, the model shows promise as a practical tool for early risk stratification,... read more

Increased Lactate Dehydrogenase to Albumin Ratio Associated with Short-term Mortality in Septic ICU Patients

Elevated lactate dehydrogenase to albumin ratio (LAR) was found to be significantly associated with an increased risk of all-cause mortality at 28 and 90 days in septic patients. LAR was suggested to be promising biomarker... read more

Procalcitonin Correlation with SEPSIS Severity in ICU Patients

High rates of morbidity and death are linked to sepsis, a potentially fatal illness. Procalcitonin (PCT), a biomarker of bacterial infection, is increasingly used in sepsis management to evaluate disease severity and guide... read more

Association Between SHR and Mortality in Patients with Heart Failure Complicated by Sepsis

This study suggests that stress hyperglycemia ratio (SHR) may be a valuable predictor of prognosis in patients with heart failure combined with sepsis. Both high and low SHR values are associated with poorer outcomes.... read more

Plasma Proteome Temporal Changes Associated with Sepsis Mortality

Our proteomics approach revealed significant associations between changes in the plasma proteome within the first days of sepsis and mortality as well as disease severity. We identified and characterised the underlying... read more

An Optimal Antibiotic Selection Framework for Sepsis Patients Using AI

In this work we present OptAB, the first completely data-driven online-updateable antibiotic selection model based on Artificial Intelligence (AI) for Sepsis patients accounting for side-effects. OptAB performs an iterative... read more

Lymphocyte Count Trajectories Associated with Prognosis of Sepsis Patients

Three distinct lymphocyte trajectories were identified in sepsis patients using GBTM. Trajectory 3 was a strong predictor of 7-day and 28-day mortality, while Trajectory 1 was associated with early death. These findings... read more

Rethinking Energy and Protein Provision for Critically Ill Patients

In critically ill patients, we suggest that energy and protein be delivered progressively in stable or recovering patients. If a patient deteriorates, regardless of days spent in the ICU, low-dose energy and protein should... read more

UFNET Fluid Removal Strategy Secured by Hemodynamic Monitoring vs. Standard of Care in patients with CRRT

An early and active UFNET strategy secured by an advanced hemodynamic protocol using dynamic indices of preload dependence had the capacity to control H72 FB in an ICU population of patients with acute circulatory failure,... read more

Correlation of Serum Albumin Levels With the Severity of Sepsis Among ICU Patients

In the present study, serum albumin level was noted as a reliable predictor of sepsis severity in ICU patients. Lower serum albumin levels were associated with higher SOFA scores, indicating more severe sepsis. This study... read more

Procalcitonin and Neutrophil to Lymphocyte Ratio Trends in ICU Sepsis Patients

Understanding the trends of PCT and NLR concerning the infection source can provide deeper insights into their diagnostic and prognostic capabilities. This comparative analysis of PCT, NLR, and SOFA score trends contributes... read more

Plasma Bioactive Adrenomedullin Predicts Mortality and Need for Dialysis in Critical COVID-19

In this study, serial bio-ADM samples in the ICU had limited predictive power for mortality in critically ill COVID-19 patients when looking at absolute values. Still, relative changes over time showed a much better prediction.... read more

Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy

In this randomized clinical trial of adults in the ICU with septic shock and severe endotheliopathy, infusion of iloprost, 1 ng/kg/min, for 72 hours did not reduce mean daily SOFA scores compared with placebo. In a clinical... read more