Tag: SOFA

Septic Shock Metabolic Subgroups and Clinical Outcome

Three metabolic clusters exist in patients with septic shock with most metabolites differing between clusters and lipid species being most influential. Cluster proportions evolved over time with a high metabolite group... read more

Rapid Clinical Effects of Convalescent Plasma Therapy in Severe COVID-19 ARDS

Administration of convalescent plasma (CP) in critically ill COVID-19 patients leads to a rapid and highly significant improvement of sequential organ failure assessment (SOFA) score along with improvements in respiratory... read more

TyG Index And Short-term Mortality in Patients with Cardiogenic Shock

The triglyceride-glucose (TyG) index is significantly associated with short-term mortality in patients with cardiogenic shock (CS) and may serve as a useful biomarker for risk stratification. This retrospective cohort... read more

Promising Prognostic Predictors in Sepsis Patients Using Lactate and Albumin Ratio

Serum Lactate/Albumin ratio and BAR ratio were significantly higher in sepsis and/or septic shock and associated with increased length of hospital stay and increased in-hospital mortality and poor clinical outcome inside... read more

Association Between Ketamine Use and Mortality in Critically Ill Patients Receiving Mechanical Ventilation

In this retrospective study, we observed that younger patients with acute respiratory distress syndrome (ARDS) may benefit from ketamine use in terms of 14-day mortality. However, these benefits were not observed in longer-term... read more

Peripheral and Respiratory Muscle Weakness and Functional Impairments in ICU Patients

This study demonstrated that patients discharged from ICU in this resource-constrained setting presented with peripheral and respiratory muscle weakness at unit discharge. Muscle weakness occurred despite a short ICU... read more

Standard vs. Double Dosing of Beta-lactam Antibiotics in Critically Ill Sepsis Patients

The BULLSEYE trial is a randomized controlled study designed to enhance the treatment of critically ill patients with septic shock. The concept of administering higher and double doses of beta-lactams in such patients... read more

Eosinopenia as a Predictor of Clinical Outcomes in CAP Patients

Contrary to previously published data, our analysis did not demonstrate an association between eosinopenia and increased mortality risk in hospitalized patients with community-acquired pneumonia (CAP), highlighting the complexity... read more

Methylprednisolone vs. Hydrocortisone in Septic Shock Patients

Corticosteroids play an important role in the management of septic shock patients, especially in those with higher doses of vasopressor. However, the therapeutic benefits of corticosteroids are not limited to hydrocortisone... read more

Assessing the Risk of Poor Clinical Outcomes in Preterm Neonates with Late-onset Sepsis

A predictive calculator for assessing the risk of poor clinical outcomes in preterm neonates with late-onset sepsis (LOS) has been developed. By leveraging readily available clinical data at the time of blood culture collection,... read more

Electrical Impedance Tomography for PEEP Titration in ARDS Patients

ARDS patients may benefit from electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration. The real-time bedside assessment of regional ventilation provided by EIT may result in improved... read more

Evaluation of Vitamin D Supplementation in Critically Ill Patients

Vitamin D supplementation in critically ill patients may shorten ICU or hospital length of stay, improve SOFA scores, or reduce the duration of mechanical ventilation. Its ability to lower 28-day mortality remains uncertain,... read more

Rapid and Accurate Sepsis Identification Using AI

This study demonstrates that by providing streamlined predictions using CBC+DIFF data without requiring extensive clinical parameters, the AI-CDSS can be seamlessly integrated into clinical workflows, enhancing rapid, accurate... read more

Managing Recurrent Septic Shock – Dual Blood Purification with CytoSorb and oXiris

This case report presents a patient with recurrent septic shock who experienced significant clinical improvement after receiving adjunctive treatment with a combination of continuous renal replacement therapy (CRRT) using... read more

Cellular Therapy with Mesenchymal Stromal Cells in Sepsis

Cellular therapy with mesenchymal stromal cells (MSCs) is a promising therapeutic modality in sepsis. Positive effects are mainly associated with frequent infusions and the dose of 1 × 106 cell/kg. Larger scale studies... read more

Association Between Early Ondansetron Use and Sepsis Risk in ICU Patients

In both patients with SOFA 3, early ondansetron use was correlated with a reduced risk of sepsis. Patients with early ondansetron use had lower odds of experiencing sepsis than patients without early ondansetron use, which... read more

Predicting Sepsis Outcomes – Efficacy of Early Warning Scores

In resource-limited settings, NEWS proved to be the most effective tool for early risk stratification in sepsis patients. Its adoption could significantly enhance sepsis management and improve outcomes in emergency departments... read more

Using Critical Ultrasound To Predict Early Diagnosis of ICU-acquired Weakness in Septic Patients

This study uncovered pivotal indicators for predicting the occurrence of ICUAW in septic patients. Despite no significant difference in age, gender, BMI, BSA, or SOFA scores between the two groups, the significant differences... read more

Developing a Rapid Screening Tool for High-risk ICU Sepsis Patients

This study demonstrates that machine learning-based prediction models for sepsis can enhance clinical outcomes through accurate risk assessment during the critical first 24h of ICU admission. Despite healthcare system... read more

Establishment and Validation of a Risk Prediction Model for Sepsis-Associated Liver Injury in ICU Patients

This novel nomogram effectively predicts SALI risk in sepsis patients by integrating readily available clinical parameters. While external validation is needed, the model shows promise as a practical tool for early risk stratification,... read more

Increased Lactate Dehydrogenase to Albumin Ratio Associated with Short-term Mortality in Septic ICU Patients

Elevated lactate dehydrogenase to albumin ratio (LAR) was found to be significantly associated with an increased risk of all-cause mortality at 28 and 90 days in septic patients. LAR was suggested to be promising biomarker... read more

Procalcitonin Correlation with SEPSIS Severity in ICU Patients

High rates of morbidity and death are linked to sepsis, a potentially fatal illness. Procalcitonin (PCT), a biomarker of bacterial infection, is increasingly used in sepsis management to evaluate disease severity and guide... read more