Burn Resuscitation: The Shift to Precision

Paradigm Shift: The focus is moving away from rigid formulas toward individualized, goal-directed strategies to manage severe burn injury. The Goldilocks Problem: There is increasing emphasis on avoiding both under-resuscitation... read more

Coordinated Critical Care: Essential ICU Strategies for Severe Trauma

The effective management of severe trauma patients hinges on seamless, perfect coordination across prehospital care, the trauma bay, and the ICU. Once in the Intensive Care Unit, the primary goals are the prompt control of... read more

A Shift in Strategy: Rethinking Blood Transfusions for Brain Injury

Recent clinical trials have challenged the standard practice of using a restrictive Red Blood Cell (RBC) transfusion strategy for critically ill brain-injured patients (ABI). Restrictive Approach is Questioned: The prevailing... read more

Restrictive vs. Liberal Transfusion Strategy in Patients with Spontaneous ICH

Red blood cell transfusions are commonly administered to anemic patients with spontaneous intracerebral hemorrhage (ICH); however, the optimal hemoglobin threshold to initiate transfusion is uncertain in this population.... read more

Recent Advances in Severe Sepsis and Septic Shock Management

This review highlights recent advances in the treatment of severe sepsis and septic shock, emphasizing new strategies aimed at improving overall survival and reducing mortality in this patient population. Despite years... read more

Awareness Strategies and the Physiological Pain Impact in Prehospital Analgesia Management

Developing awareness strategies for prehospital pain management could improve analgesic outcomes, but further research is needed to understand the physiological impact of pain on vital systems. Investigating these dynamics... read more

Barriers to Early Mobilization Perceived by PICU Staff

There is a need to implement educational and organizational interventions in the PICU to overcome the identified barriers. Training staff, clarifying roles and responsibilities, as well as promoting a culture that values... read more

COVID-19 Airway Management and Ventilation Strategy for Critically Ill Older Patients

This book describes the issues and challenges that clinicians encountered in the management of older critically ill patients during the COVID-19 pandemic, and offers practical information on how to manage them. Older... read more

COVID-19 Airway Management and Ventilation Strategy for Critically Ill Older Patients

Effect of Antimicrobial De-escalation Strategy on 14-day Mortality Among ICU Patients

The prevalence of antimicrobial de-escalation (ADE) strategy was low among intensive care unit patients. The ADE strategy demonstrated a protective effect or no adverse effect on 14-day mortality compared to the No Change... read more

Clarifying the Fictions Surrounding Sepsis: Strategies for Improved Management and Outcomes

It is important to clarify the myths surrounding sepsis and to provide a clear understanding of the condition. This can help set realistic expectations about outcomes and inform effective strategies for managing sepsis, including... read more

The Family in Preventing Delirium in the ICU

Extended visits, development of family-mediated activities, and redirection are non-pharmacological strategies that reduce the incidence of delirium in the ICU and offer multiple benefits to the patient and family/caregiver. The... read more

Effect of Intra-arrest Transport, ECPR, and Treatment on Functional Neurologic Outcome

Among patients with refractory out-of-hospital cardiac arrest, the bundle of early intra-arrest transport, extracorporeal cardiopulmonary resuscitation (ECPR), and invasive assessment and treatment did not significantly improve... read more

Cluster ICU Treatment Strategies for TBI by Hospital Treatment Preferences?

Although correlations between treatment policies within domains were found, the failure to cluster hospitals indicates that a specific treatment choice within a domain is not a proxy for other treatment choices within or... read more

Mesenchymal Stem/Stromal Cell-based Therapies for Severe Viral Pneumonia

Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited... read more

Endotracheal Intubation vs. Supraglottic Procedure in Pediatric OHCA

The findings of this large cohort study suggest that endotracheal intubation (ETI) in pediatric out-of-hospital cardiac arrest (OHCA), although performed by trained physicians, is associated with a worse outcome, regardless... read more

The Effect of Lowering Tidal Volume on Mortality

The use of low tidal volume (4-8 ml/kg of predicted body weight) has been considered the default way to ventilate patients with acute respiratory distress syndrome (ARDS) to minimize ventilator-induced lung injury (VILI).... read more

Expanding ECMO Cannulation Strategies in Neonatal Respiratory Failure

Infants with refractory respiratory failure who require extracorporeal membrane oxygenation (ECMO) have traditionally been cannulated via the venoarterial route or by using a dual-lumen venovenous cannula in the right internal... read more

Imputation Strategies for Missing Baseline Neurological Assessment Covariates After TBI

Statistical models for outcome prediction are central to traumatic brain injury (TBI) research and critical to baseline risk adjustment. Glasgow coma score (GCS) and pupil reactivity are crucial covariates in all such models... read more

Factors Associated With Initiation of ECPR in the Pediatric Population

Although extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly utilized in the pediatric critical care environment, our understanding regarding pediatric candidacy for ECPR remains unknown. Our objective... read more

Delayed Strategies for RRT Initiation for Severe AKI

In severe acute kidney injury (AKI) patients with oliguria for more than 72 h or blood urea nitrogen concentration higher than 112 mg/dL and no severe complication that would mandate immediate RRT, longer postponing of renal... read more

Rapid Design & Implementation of Post-COVID Clinics

Survivors of COVID-19 are a vulnerable population, with complex needs owing to lingering symptoms and complications across multiple organ systems. Those who required hospitalization or intensive care are also at risk for... read more

Transfusion Strategies for Acute Upper Gastrointestinal Bleeding

As compared with a liberal transfusion strategy, a restrictive strategy significantly improved outcomes in patients with acute upper gastrointestinal bleeding. We enrolled 921 patients with severe acute upper gastrointestinal... read more