Tag: study
We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt
Melbourne’s second wave of COVID-19 last year, which led to a lockdown lasting more than 100 days, provided us with many lessons about controlling transmission. Some of these are pertinent as New South Wales endures its... read more
Dynamic and Hybrid Configurations for ECMO
Dynamic or hybrid configurations for extracorporeal membrane oxygenation (ECMO) are needed when patient physiology or clinical conditions change. Dynamic configurations included configurations converting from veno-arterial... read more
Educational Initiatives for EEG in the Critical Care Setting
It is feasible to teach basic electroencephalography (EEG) to participants in critical care settings from different clinical backgrounds, including physicians and nurses. Brief training programs can enable bedside providers... read more
Patients Discharged From the ICU on a Dopamine Infusion
Despite a higher ICU readmission rate, ICU discharge of patients on dopamine infusion was not associated with increased mortality. The hospital mortality rate was comparable in both groups, despite that the median logistic... read more
Convalescent Plasma for COVID-19 in Hospitalised Patients
Convalescent plasma (CP) and standard of care (SOC) did not result in a higher proportion of clinical improvement on at day 28 in hospitalised patients with COVID-19 compared to SOC alone. This is an investigator-initiated,... read more
Predicting Adverse Outcomes in COVID-19 Patients Using BV5%
Evidence suggests that vascular inflammation and thrombosis may be important drivers of poor clinical outcomes in patients with COVID-19. We hypothesized that a significant decrease in the percentage of blood vessels with... read more
Inhaled Budesonide Improves Time to COVID-19 Recovery
Inhaled budesonide improves time to recovery, with a chance of also reducing hospital admissions or deaths (although our results did not meet the superiority threshold), in people with COVID-19 in the community who are at... read more
Impact of ABCDE Bundle Implementation in the ICU on Specific Patient Costs
Full ABCDE bundle implementation resulted in a decrease in total hospital laboratory costs and total hospital laboratory and diagnostic resource utilization while leading to an increase in physical therapy costs. The full... read more
Time Course of Risk Factors Associated with COVID-19 Mortality
The present multicentric study describes 1,260 critically ill patients with COVID-19-associated acute respiratory failure consecutively admitted to 24 Italian ICUs during the first pandemic wave. This study specifically... read more
COVID-19 Variants in Patients with Immunosuppression
Patients with immunosuppression are at risk for prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In several case reports, investigators have indicated that multimutational SARS-CoV-2... read more
Full Vaccination Suppresses COVID-19 Delta Variant Mutation Frequency
This study presents the first evidence that full vaccination against COVID-19 suppresses emergent mutations of SARS-CoV-2 delta variants. An evolution algorithm, Tajima's D test with a threshold value as -2.50, can provide... read more
Diagnostic Errors in Pediatric Critical Care
Knowledge of diagnostic errors in the PICU is limited. Future work to understand diagnostic errors should involve a balanced focus between studying the diagnosis of individual diseases and uncovering common system- and process-related... read more
Use of Bivalirudin for Anticoagulation in Pediatric ECMO
This study describes the use of bivalirudin in children on extracorporeal membrane oxygenation (ECMO). Pediatric patients receiving bivalirudin were compared to patients receiving heparin as the anticoagulant on ECMO. Data... read more
Expanding ECMO Cannulation Strategies in Neonatal Respiratory Failure
Infants with refractory respiratory failure who require extracorporeal membrane oxygenation (ECMO) have traditionally been cannulated via the venoarterial route or by using a dual-lumen venovenous cannula in the right internal... read more
Variations in End-of-Life Practices in ICUs Worldwide
Limitation of life-sustaining therapies is common worldwide with regional variability. Withholding treatment is more common than withdrawing treatment. Variations in type, frequency, and timing of end-of-life decisions were... read more
RECOVERY-RS trial finds CPAP reduces need for invasive ventilation in hospitalised COVID-19 patients
The NIHR-supported Respiratory Strategies in COVID-19; CPAP, High-flow, and Standard Care (RECOVERY-RS) trial has demonstrated that treating hospitalised COVID-19 patients who have acute respiratory failure with continuous... read more
Cystic Fibrosis in the COVID-19 Pandemic
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of life-threatening COVID-19 are believed to disproportionately affect certain at-risk populations. However, it is not clear whether... read more
Progressive Increase in Virulence of COVID-19 Variants
The progressive increase in transmissibility and virulence of SARS-CoV-2 VOCs will result in a significantly larger, and more deadly, pandemic than would have occurred in the absence of variants of concern (VOC) emergence. The... read more
Intubation Timing As Determinant Of Outcome in Patients with ARDS By COVID-19 Infection
In COVID-19 patients, late intubation, Pafi ... read more
Higher ICU Sepsis Case Volume Associated with Significantly Lower Hospital Mortality
In this cohort study of 273,001 patients with sepsis at 231 ICUs in the UK, a higher annual sepsis case volume in the ICU was associated with significantly lower hospital mortality, and this association had no significant... read more
Reliability of Mechanical Ventilation During Continuous Chest Compressions
All investigated transport ventilators were able to provide alveolar ventilation even though chest compressions considerably decreased tidal volumes. Our results support the concept of using ventilators to avoid excessive... read more
Intensive care–treated cardiac arrest: a retrospective study on the impact of extended age on mortality, neurological outcome, received treatments and healthcare-associated costs
The elderly ICU-treated CA patients in this study had worse neurological outcomes, higher mortality and lower cost-effectiveness than younger patients. Elderly received less intense treatment. Further efforts are needed... read more
