Tag: study
COVID-19 Surges Increased Patient Mortality
A recent study by scientists at the National Institutes of Health suggests that one in every four COVID-19 deaths in the United States may be attributed to hospitals strained by surging caseloads. Published in the Annals... read more
Reduced Sensitivity of COVID-19 Variant Delta to Antibody Neutralization
The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes... read more
New Device for Intubation Through a Laryngeal Mask Airway
On review of the literature, it is abundantly obvious that an endotracheal tube (ETT) with a posterior-facing bevel and curved or tapered tip to center the tube on the scope and reduce hang-up is ideal for intubation over... read more
Is Daily Enoxaparin Dosing As Good As Twice Daily?
Venous thromboembolism (VTE) remains a big problem for trauma professionals and the patients they take care of. Every trauma center has some sort of VTE prophylaxis protocol for stratifying risk, prescribing mechanical... read more
Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations
In uncontrolled, moderate-to-severe asthma, higher baseline FeNO levels were associated with greater risk of severe asthma exacerbations, particularly in combination with elevated eosinophil count and prior exacerbations,... read more
Melatonin for Delirium Prevention in Hospitalized Patients
Melatonin/ramelteon are associated with reduction in delirium incidence in hospitalized patients. However, this effect seems confined to surgical and ICU patients. The optimum dosage and formulation of melatonin, and... read more
Preoperative vena cava filter placement in recurrent cerebral fat embolism following traumatic multiple fractures
Despite scarce evidence, we reckon that Inferior Vena Cava Filter (IVCF) could improve prognosis in selected patients with fat embolism syndrome (FES), especially those presenting high risk factors, after accurately weighing... read more
REGN monoclonal antibodies work in selected hospitalised COVID-19 patients
New findings suggest a significant benefit from REGN in terms of the primary outcome of mortality for patients who have low levels of their own antibodies at the time of admission. This was an unexpected result for me... read more
Multimorbidity on Long-Term Outcomes Following ICU Discharge
This national cohort study has demonstrated increased resource use for critical care survivors in the year following discharge but fails to replicate past findings of increased longer-term mortality. Multimorbidity, lifestyle... read more
Percutaneous Dilational Tracheostomy for COVID-19 Patients Requiring Mechanical Ventilation
Patients with COVID-19 who survive the early days of MV experience severe and prolonged respiratory failure. An early modified percutaneous dilational tracheostomy (PDT) was safe for patients and healthcare providers and... read more
Dealing with missing delirium assessments in prospective clinical studies of the critically ill
For longitudinal data where a summary exposure is of interest, we recommend practitioners adopting the passive imputation strategy. Simulations show that all methods performed comparably when the proportion of missingness... read more
RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more
Imatinib in COVID-19: Hope and Caution
Despite the undoubted progress achieved with the first vaccines against SARS-CoV-2 infection, the COVID-19 pandemic continues to affect thousands of people across the globe, particularly in those countries where vaccination... read more
ICP Monitoring in Patients with Acute Brain Injury
The use of intracranial pressure (ICP) monitoring and ICP management varies greatly across centres and countries. The use of ICP monitoring might be associated with a more intensive therapeutic approach and with lower 6-month... read more
Do Not Attempt CPR Decisions in People Admitted with Suspected COVID-19
Early do not attempt cardiopulmonary resuscitation (DNACPR) decisions were associated with recognised predictors of adverse outcome, and were inversely associated with Asian ethnicity. Most people with an early DNACPR decision... read more
Reducing the Global Sepsis Burden: A Positive Legacy for the COVID-19 Pandemic?
ESICM, SCCM, and the GSA published a consensus paper in Intensive Care Medicine, emphasising the importance of recognising that patients critically ill with COVID-19 have viral sepsis, despite some differences from sepsis... read more
Optimizing the Timing of RRT in AKI
The optimal timing of renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI) has been much debated. Over the past five years several studies have provided new guidance for evidence-based... read more
Standardized post-resuscitation damage assessment of two mechanical chest compression devices
The LUCAS 2 device shows superior resuscitation outcomes and less thoracic injuries compared to Corpuls cpr when used for experimental CPR in juvenile pigs. Researchers should be aware that different mCCDs for experimental... read more
Effects of 5% Albumin Plus Saline vs. Saline Alone on Outcomes From Large-Volume Resuscitation in Critically Ill Patients
During large-volume resuscitation, 5% albumin was associated with reduced mortality and major adverse kidney event at 30, 90, and 365 days. However, a higher rate of acute kidney injury of any stage was observed that did... read more
Evolving Changes in Mortality of Critically Ill with COVID-19 Over 8 Months
Age and mortality rates have declined over the first 8 months of the pandemic. The use of non-invasive respiratory support (NIRS) as the first respiratory support measure was associated with survival, but causal inference... read more
What is the Ideal Approach for Emergent Pericardiocentesis Using POCUS Guidance?
A total of 166 pericardial effusions were identified during the study period. The mean skin-to-pericardial fluid distance was 5.6 cm for the subxiphoid views, which was significantly greater than that for the parasternal... read more
Do team and task performance improve after training situation awareness?
This intervention study shows that a 2-h education in situation awareness improved parts of team performance in an acute care situation. Team leadership and task management improved in the intervention group, which may indicate... read more
