Tag: study
Comparing Procedural Amnesia and Respiratory Depression vs. MS and DS with Propofol
Targeting moderate sedation (MS) or deep sedation (DS) did not reliably result in the intended sedation level. Targeting MS, however, resulted in a lower rate of total AREs and fewer patients had multiple AREs with no difference... read more
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS
In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more
Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status
Moderate to severe anxiety at ICU admission is associated with early occurrence of new organ failure in critically ill patients, independently of respiratory status and severity of critical illness. The causality link could... read more
Physiologic Assessment: Variation in Fluid and Vasopressor Use in Shock
The decision whether to give more fluid during the management of shock can be somewhat provider-dependent. This multicenter prospective cohort study evaluated 1639 patients with hypotension requiring vasopressors. The... read more
Serum Levels of Receptor-interacting Protein Kinase-3 in Patients with COVID-19
Patients with coronavirus disease 2019 (COVID-19) can develop acute respiratory distress syndrome (ARDS), which has been linked to poor prognosis and is a major contributor to patient death. A better understanding of the... read more
Holding and Mobility of Pediatric Patients With Transthoracic Intracardiac Catheters
Pediatric patients with transthoracic intracardiac catheters can be safely held and mobilized out of bed. A total of 1,358 patients had activity and positioning documented while transthoracic intracardiac catheters were... read more
COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis
Glucocorticoids probably reduce mortality and mechanical ventilation in patients with COVID-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials... read more
Hypothermia Plus Melatonin in Asphyctic Newborns
The early addition of IV melatonin to asphyctic neonates is feasible and may improve long-term neurodevelopment. To our knowledge, this is the first clinical trial to analyze the administration of IV melatonin as an adjuvant... read more
Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19
Recent studies have provided insights into the pathogenesis of COVID-19. Yet, longitudinal immunological correlates of disease outcome remain unclear. Here, we serially analysed immune responses in 113 COVID-19 patients with... read more
30% of COVID-19 Patients Had No Symptoms of Fever, Cough, or Shortness of Breath
The findings of this cohort study suggest that screening based on conventional COVID-19 symptoms or corresponding examination findings of febrile respiratory illness may not possess the necessary sensitivity for early diagnostic... read more
Rapid Advancement in Enteral Nutrition Does Not Affect Systemic Inflammation and Insulin Homeostasis Following Pediatric Cardiopulmonary Bypass Surgery
A FF strategy was not associated with changes to early enteral nutrition delivery. Inflammation, insulin resistance, and morbidity were similar, but FF may modify the relationship between inflammation and adverse event. Multicenter... read more
Dexmedetomidine for Prolonged Sedation in the PICU
High-quality data on dexmedetomidine use for prolonged sedation and a consensus on correct dosing and weaning protocols in children are currently missing. Infusion of dexmedetomidine can be considered relatively safe in pediatrics... read more
Preventing Major Airway Complications
Every anaesthetist fears the moment they might become faced with a "can't intubate, can't oxygenate" (CICO) scenario, but thankfully such events are exceedingly rare. They nevertheless receive much attention in the academic... read more
Factors Associated With Death in Critically Ill Patients With COVID-19 in the US
This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies... read more
