Tag: study
Early Oseltamivir Therapy Improves the Outcome in Critically Ill with Influenza
This real-life study emphasizes oseltamivir efficacy on in-hospital outcome when administrated within 2 days of the onset of symptoms. Even if physicians' awareness of the influenza disease has been undeniably enhanced... read more
Humanizing the Treatment of Hyperactive Delirium in the Last Days of Life
When patients with advanced cancer near the end of their life, it is important for physicians, nurses, and other health care personnel to respect and dignify the dying process of the patient. This requires a shift in focus... read more
Sound and Light Levels Are Similarly Disruptive in ICU and non-ICU Wards
Quieter, non-ICU wards have as many SLCs as ICUs do, which has implications for quality improvement measurements. Efforts to further reduce average noise levels might be counterproductive. Light levels in the hospital (ICU... read more
2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis
Sepsis is a leading cause of death in the United States, but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on... read more
Rapid Retriage of Critically Injured Trauma Patients
Critically injured patients presenting to nontrauma hospitals require timely transfer to trauma centers; however, the transfer process varies and differences in outcomes for patients from trauma centers are unknown. We evaluated... read more
Acute Kidney Injury Is Risk Factor for Delirium and Coma
For critically ill adults, acute kidney injury is a risk factor for delirium and coma. Stage 2 acute kidney injury was associated with increased risk of delirium and coma (odds ratios, 1.55 and 2.04, respectively), as was... read more
Does Early Mobilization Reduce Time in the Surgical ICU?
Is early mobilization in the surgical intensive care unit (ICU) beneficial? Here is a multicenter, randomized, controlled trial in five university hospitals, where they recruited a total of 200 patients.... read more
Oestrogen Inhibition Reverses PAH and Associated Metabolic Defects
Increased oestrogen is a strong epidemiological risk factor for development of pulmonary arterial hypertension (PAH) in patients, associated with metabolic defects. In addition, oestrogens drive penetrance in mice carrying... read more
Should Transfusions Be Matched by Sex?
In the first large study to look at how blood transfusions from previously pregnant women affect recipients' health, researchers discovered men under 50 were 1.5 times more likely to die in the three years following a transfusion... read more
Risk of AKI After Intravenous Contrast Media Administration
In the largest well-controlled study of acute kidney injury (AKI) following contrast administration in the ED to date, intravenous contrast was not associated with an increased frequency of acute kidney injury. Rates of acute... read more
Understanding Patient Outcomes After ARDS
We identified four post-ARDS outcome subtypes that were predicted by sex, ethnicity, pre-ARDS smoking status and other baseline factors. These subtypes may help develop tailored rehabilitation strategies, including investigation... read more
A Better Way to Detect Sepsis in Kids in the ED
We have been interested in this question for a long time here at CHOP and have done several interventions over the past several years to try to improve our ability to recognize children with septic shock. When we started... read more
Longer hospital stay linked to low health literacy
Low health literacy is associated with a longer hospital length of stay among general medicine patients, according to a study published in the Journal of Hospital Medicine. Ethan G. Jaffee, MD, from Massachusetts General... read more
Frailty Association with Perioperative Morbidity in Patients After Ambulatory General Surgery Operations
Frailty is associated with increased perioperative morbidity in common ambulatory general surgery operations, independent of age, type of anesthesia, and other comorbidities. Surgeons should consider frailty rather than chronological... read more
Comparison of Postoperative Outcomes Among Patients Treated by Male and Female Surgeons
After accounting for patient, surgeon, and hospital characteristics, patients treated by female surgeons had a small but statistically significant decrease in 30 day mortality and similar surgical outcomes (length of stay,... read more
Tenfold increase in childhood and adolescent obesity in four decades
The number of obese children and adolescents (aged five to 19 years) worldwide has risen tenfold in the past four decades. If current trends continue, more children and adolescents will be obese than moderately or severely... read more
Rapid genetic testing useful for diagnosis of critically ill children
In a cohort of children under the age of 12 months admitted to the intensive care unit (ICU) without a clear diagnosis, rapid, targeted genetic testing revealed a diagnosis in about one-third of patients. Genetic diagnoses... read more
Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients
This prospective observational multicentre study (ARREVE) was done in 43 French ICUs to compare terminal weaning and immediate extubation, as chosen by the ICU team. Terminal weaning was a gradual decrease in the amount of... read more
Hypothermia No Help When Cardiac Arrest Occurs in Hospital
While therapeutic hypothermia may help improve some outcomes, it doesn't appear to provide benefit when cardiac arrest happens in a hospital setting, according this study.... read more
Cooling therapy might not help all cardiac arrest patients
While cooling patients whose hearts stop suddenly outside the hospital may help improve outcomes, it doesn't seem to show the same benefit when cardiac arrest happens in a hospital setting, a new study suggests.... read more
Study suggests a new tool for diagnosing post-concussion syndrome
Unlike more common diagnostic tools, including magnetic resonance imaging and computerized axial tomography scan, diffusion tensor imaging, or DTI, effectively scans for micro abnormalities that may often go undetected by... read more
Post-ICU syndrome signals need for better transition between life-saving care and return to life
Studies show that there are a range of reactions to a stay in the ICU, from the physical wasting that patients experience when they're prone and immobilized to the emotional problems that can come with surviving a near-death... read more
