Tag: TBI
Lung Protection Saves Brains: Low Tidal Volume Tied to Lower Mortality
This international cohort study involving 1,510 patients with Acute Brain Injury (ABI) across 73 ICUs investigated the impact of Low-Tidal-Volume Ventilation (LTVV) on outcomes. In this group, where the most common etiology... read more
Neuro-ICU Admissions: Lower Mortality, Higher Disability Risk
This large-scale retrospective cohort study analyzed the clinical and epidemiological profiles of over 62,000 Intensive Care Unit (ICU) patients across seven hospitals, finding that the 10,884 patients admitted for primary... read more
Brain Imaging Reveals Hidden Awareness in Critically Ill ICU Patients
This study investigated covert awareness—preserved consciousness without observable behavioral signs—in critically ill patients with acute brain injuries in the Intensive Care Unit (ICU). Researchers used functional... read more
A Shift in Strategy: Rethinking Blood Transfusions for Brain Injury
Recent clinical trials have challenged the standard practice of using a restrictive Red Blood Cell (RBC) transfusion strategy for critically ill brain-injured patients (ABI). Restrictive Approach is Questioned: The prevailing... read more
The REGULATE Trial: Finding the Best Blood Pressure Drug for Severe Brain Injury
The REGULATE trial is a crucial, large-scale, randomized study designed to determine the optimal vasopressor (blood pressure medication) strategy for patients with severe traumatic brain injury (TBI). The goal is to see... read more
REGULATE Trial: Norepinephrine vs. Vasopressin – The Head-to-Heart Showdown in Severe TBI
REGULATE is the first adequately powered trial to systematically compare these vasopressor strategies in severe TBI. The results are expected to provide an evidence-based foundation for developing individualized vasopressor... read more
Medication Management: Spontaneous vs. Traumatic Intracerebral Hemorrhage (sICH vs. tICH)
Pharmacological management for BP control and seizure prophylaxis differs between tICH and sICH. ICH etiology should be accounted for in determining appropriate BP goals and the necessity of seizure prophylaxis. Intracerebral... read more
Restrictive vs. Liberal Transfusion Strategy in Patients with Spontaneous ICH
Red blood cell transfusions are commonly administered to anemic patients with spontaneous intracerebral hemorrhage (ICH); however, the optimal hemoglobin threshold to initiate transfusion is uncertain in this population.... read more
Impact of Low-Dose Ketamine Infusion on Intracranial Pressure and Hemodynamics in Septic Shock Patients
Adult patients with septic shock, on hemodynamic support, had high-to-normal intracranial pressure (ICP). Low-dose continuous ketamine infusion as an adjunct sedative appeared to have favorable outcomes concerning ICP and... read more
The Role of Neuroimaging in Brain Death Diagnosis
Brain death remains a medically and ethically complex topic, due to its religious and philosophical implications, despite the attempt to "scientificise" what is death and what is not. BD is characterized by a lack of universal... read more
TBI Management in the ICU
Despite advances in the management of traumatic brain injury (TBI) in the intensive care unit (ICU), and the implementation of new diagnostic techniques and monitoring modalities, the rate of poor neurological outcomes remains... read more
TBI: Quantifying Methodological Uncertainties and Navigating Feasibilities in Monitoring of Cerebral Autoregulation
Traumatic brain injury (TBI) remains a critical medical challenge due to its heterogeneous nature and complex pathophysiological mechanisms. Individualized management of TBI patients, taking advantage of such technologies... read more
Prophylactic IV Antibiotics Outcomes in Patients with Acute Severe Brain Injury on Mechanical Ventilation
Among critically ill patients with acute brain injury, prophylactic IV antibiotics were associated with less VAP but not with changes in length of stay, mortality, or neurologic outcomes. Patients with structural brain... read more
Ventilation Practices in ABI Patients and Association with Outcomes
Current mechanical ventilation practices for patients with acute brain injury (ABI) are poorly defined. This study aimed to describe ventilator settings/parameters used in intensive care units (ICUs) and evaluate their association... read more
Management of Severe Traumatic Brain Injury
"Management of Severe Traumatic Brain Injury" is a practical, comprehensive guide to the treatment of patients (both adults and children) with such injuries, from the time of initial contact through to the rehabilitation... read more
Non-invasive ICP Monitoring for TBI Patients When Invasive Systems Not Available
Using a mixed-method approach involving literature review and an in-person consensus by experts, a set of recommendations designed to assist clinicians managing traumatic brain injury (TBI) patients using nICP systems plus... read more
Handbook on the Neuropsychology of Traumatic Brain Injury
This book collects and synthesizes the latest thinking on the condition in its variety of cognitive and behavioral presentations, matched by a variety of clinical responses. Acknowledging the continuum of injury and the... read more
Assessing TBI with Transorbital Sonography
Transorbital sonography (TOS) represents an innovative tool for neurological assessment. It has been validated that the presence or absence of eyelid edema does not compromise the accuracy of ultrasound-based pupillary function... read more
ECMO Use in Pediatric Trauma: National Trauma Data Bank Report
The findings of this study support the increasing use of extracorporeal membrane oxygenation (ECMO) as a potentially effective intervention for pediatric trauma patients, including those with TBI. While ECMO provides... read more
Risk Factors for Traumatic Intracranial Hemorrhage in Mild TBI Patients
The findings from this study provide additional context to risk factors currently in use as components in guidelines for the management of mild traumatic brain injury (mTBI) in the ED setting, contrasting high risk predictors... read more
Antithrombin III Levels and Outcomes Among Patients With Trauma
In this cohort study of trauma patients, antithrombin III deficiency was associated with greater severity of illness and worse hospital outcomes. Specifically, antithrombin III deficiency was associated with fewer ventilator-free... read more
Patients with TBI: Characteristics, Triage, Primary Referral and Mortality
Traumatic brain injury (TBI) is a potential high-risk condition, but appropriate care pathways, including prehospital triage and primary referral to a specialized neurosurgical centre, can improve neurological outcome and... read more
