Tag: trial

Effect of Vitamin C and Thiamine on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock

A 2020 randomized trial reported no difference in duration of time alive and free of vasopressor administration at 7 days among intensive care unit (ICU) patients with septic shock assigned to vitamin C, thiamine, and hydrocortisone... read more

eFAST Performance with a Novel vs. Conventional Transducers

Point-of-injury extended focused assessment with sonography in trauma (eFAST) may identify life-threatening torso hemorrhage and expedite casualty evacuation. The purpose of this study was to compare combat medic eFAST performance... read more

Pretreating Transfused Erythrocytes with NO Prevents Pulmonary Hypertension

Researchers at Massachusetts General Hospital (MGH; Boston, USA), Harvard Medical School (HMS; Boston, MA, USA), and other institutions conducted a trial to see if treating stored packed sheep RBCs with NO before transfusion... read more

Could Stress Ulcer Prophylaxis Increase Mortality in High-acuity Patients?

Although considerable uncertainty remains, the inferences from SUP-ICU and PEPTIC are consistent with the hypothesis that proton pump inhibitors (PPIs) increase the risk of death in patients with higher illness severity.... read more

It’s Insane to Keep Using Mortality As a Primary Endpoint in Critical Care Trials

Mortality is an important endpoint, so we shouldn't ignore mortality trends entirely. However, the vast majority of these will be spurious. Thus, we should generally not change practice due to them. In the history of critical... read more

Tranexamic Acid in TBI – CRASH-3 Trial Treatment

The CRASH-3 trial is a multi-centre, randomised, placebo-controlled trial of the effects of tranexamic acid on death and disability in patients with traumatic brain injury (TBI). Patients with reactive pupils and/or mild... read more

Potential Therapy for Improving Sudden Cardiac Arrest Resuscitation Outcomes

The severity of cardiogenic shock following asystolic cardiac arrest is dependent on the length of cardiac arrest prior to cardiopulmonary resuscitation and is mediated by myocardial stunning resulting from mitochondrial... read more

Should We Treat Fever in Critically Ill Patients Without Acute Brain Pathology?

In one of the sessions at #LIVES2019 in Berlin, Prof. Frank Van Haren of Canberra Hospital, Australia, presented findings from the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management... read more

Management of Cardiogenic Shock Complicating Myocardial Infarction – 2019 Update

In general, randomized clinical trials in CS are difficult to perform and only three randomized trials adequately powered to detect differences in clinical outcomes achieved completion of the required number of patients. Based... read more

Health Coaching to Increase Appropriate Inhaler Use in COPD

Health coaching may provide a scalable model that can improve care for people living with chronic obstructive pulmonary disease (COPD). Baseline adherence and inhaler technique were uniformly poor and did not differ by... read more

Glucose Variability as Measured by Inter-measurement Percentage Change is Predictive of In-patient Mortality in Aneurysmal Subarachnoid Hemorrhage

Reduced glucose variability is highly correlated with in-patient survival and long-term mortality in subarachnoid hemorrhage (aSAH) patients. This finding was observed in the non-diabetic and well-controlled diabetic patients,... read more

Prone Positioning Monitored by Electrical Impedance Tomography in Patients with Severe ARDS on VV-ECMO

Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), the impact of... read more

Tranexamic Acid Has Nominal Benefit for TBI

Studies examining the use of tranexamic acid (TXA) inescapably seem to pit our rigorous methodological demons against our practical clinical angels. The CRASH-2 trial randomized 20,211 adult trauma patients presenting... read more

The ABCDE Bundle Associated with Significant Reductions in Duration of Mechanical Ventilation

The focus on long-term consequences of critical illness has intensified with increasing ICU utilization and survivorship. Post Intensive Care Syndrome (PICS) is increasingly recognized and has profound and long-lasting negative... read more

Beta-Blocker Therapy in Severe TBI

Propranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe Traumatic Brain Injury (TBI). This randomized trial speaks in favor of routine administration of beta-blocker therapy... read more

Conservative vs. Interventional Treatment for Spontaneous Pneumothorax

Although the primary outcome was not statistically robust to conservative assumptions about missing data, the trial provides modest evidence that conservative management of primary spontaneous pneumothorax was noninferior... read more

Leading EHR System Adopts Bundle to Prevent ICU Delirium

Seminal studies at Vanderbilt University Medical Center over the past two decades by pulmonary and critical care specialist Wes Ely, M.D. and colleagues have spurred ICU delirium research, and the resulting body of evidence... read more

Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in ICUs

Among ICU nurses, an intervention that included education, role-play, and debriefing resulted in a lower prevalence of job strain at 6 months compared with nurses who did not undergo this program. Further research is... read more

Can Cooling Patients Help After a Cardiac Arrest?

The cooling trial, involving nine UK hospitals, is being led by researchers at the University Hospital of Wales, Cardiff. Altogether, 1,900 patients worldwide are part of the trial, called TTM2. Half of patients were... read more

Intravenous Fluid Therapy in Critically Ill Adults

Despite the administration of intravenous fluids to critically ill patients being a near-universal intervention, the available evidence base guiding their safe and appropriate use is scarce and derived mainly from academically... read more

Activin Type II Receptor Blockade for Treatment of Muscle Depletion in COPD

Blocking the action of negative muscle regulators through the activin type II receptors with bimagrumab treatment safely increased skeletal muscle mass but did not improve functional capacity in patients with COPD and low... read more

Vitamin Treatment For Sepsis Fails In Large Trial

Hope for an effective and inexpensive treatment for the deadly condition sepsis has dimmed following results of a major new study. Researchers had hoped that a simple treatment involving infusions of vitamin C, vitamin... read more