Tag: trial
COVID-19: a boost for intensive care authorship?
Almost 180 million cases of COVID-19 have been diagnosed, with almost 4.000.000 deaths. Since this pandemic had unprecedented worldwide healthcare and socio-economic effects, the scientific world is under exceptional pressure... read more
Effects of Early Mobilization on the Prognosis of Critically Ill Patients
Early mobilization was effective in enhancing the recovery of critically ill patients, but more large-scale, multicenter randomized controlled trials are required to further confirm these findings. A total of 39 articles... read more
Clinical Trials Design Evaluating Sedation in Critically Ill Adults Requiring Mechanical Ventilation
These recommendations are intended to assist researchers in the design, conduct, selection of endpoints, and reporting of clinical trials involving sedative medications and/or sedation protocols for adult ICU patients who... read more
REGN monoclonal antibodies work in selected hospitalised COVID-19 patients
New findings suggest a significant benefit from REGN in terms of the primary outcome of mortality for patients who have low levels of their own antibodies at the time of admission. This was an unexpected result for me... read more
RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more
RRT in Critically Ill Patients with AKI
Recent evidence has shown that pre-emptive or earlier renal-replacement therapy (RRT) in patients with severe acute kidney injury (AKI) and no urgent indications does not confer clinical benefit. By default, this would imply... read more
Delirium and long term cognition in critically ill patients
Delirium, a form of acute brain dysfunction, is very common in the critically ill adult patient population. Although its pathophysiology is poorly understood, multiple factors associated with delirium have been identified,... read more
Protocol and statistical analysis plan for the PREPARE II randomised clinical trial
Cardiovascular collapse is a common complication during tracheal intubation of critically ill adults. Whether administration of an intravenous fluid bolus prevents cardiovascular collapse during tracheal intubation remains... read more
Tocilizumab Use May Be Associated with a Short-term Mortality Benefit
For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required. Its benefits may also lie in reducing the... read more
Severity of Hypoxemia may Explain Indeterminate Results in Pediatric Trials of iNO
Inhaled nitric oxide (iNO) is used for refractory hypoxemia in acute respiratory distress syndrome (ARDS) via vasodilation of pulmonary arterioles to ventilated alveoli, particularly in pediatrics. However, iNO has not affected... read more
COVID-19 Infection Induces Long-lived Bone Marrow Plasma Cells
Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity testing for effective management. Here, we describe "Systematic Parallel Analysis of RNA coupled to Sequencing for Covid-19 screening"... read more
Percutaneous Ultrasound Guided Gastrostomy Tube Placement
Percutaneous ultrasound guided gastrostomy (PUG) is similar in terms of complications to percutaneous gastrostomy tube (PRG) placement and a safe method for gastrostomy tube placement in the critically ill with the added... read more
Managing Patients With Short-Term Mechanical Circulatory Support
The use of mechanical circulatory support for patients presenting with cardiogenic shock is rapidly increasing. Currently, there is only limited and conflicting evidence available regarding the role of the Impella (a microaxial,... read more
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS
Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation... read more
Clinical strategies for implementing lung and diaphragm-protective ventilation
Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm develops atrophy as a consequence of low... read more
Checklist for Early Recognition and Treatment of Acute Illness and Injury
A quality-improvement intervention with remote simulation training to implement a decision support tool was associated with decreased nonadherence to daily care processes, shorter length of stay, and decreased mortality. The... read more
Randomised controlled trials in pre-hospital trauma
This mapping review has highlighted that evidence from trials in prehospital trauma is sparse and where trials have been completed, the reporting is generally poor and study designs sub-optimal. There is a continued need,... read more
Precision Medicine in ARDS
Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for... read more
Sepsis Subclasses: A Framework for Development and Interpretation
Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based... read more
Increasing the Reproducibility of Research Reduces the Problem of Apophenia
Apophenia, or the tendency of identifying meaningful patterns where none truly exist, is part of the human condition. We cannot surmount it, but we can strive to manage its influence. In the research context, apophenia can... read more
COVID-19: Convalescent Plasma vs. Standard Plasma
Administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection increased antibodies to severe acute respiratory syndrome coronavirus disease 2 but was not associated with improved outcome. Enrollment... read more
Promoting Evidence-Based Practice in ARDS
There is a dearth of literature addressing interventions to improve implementation of evidence-based practices in acute respiratory distress syndrome (ARDS). Existing interventions to improve clinician knowledge and facilitate... read more
