Extracorporeal Cardiopulmonary Resuscitation (ECPR) in Adults

Extracorporeal Cardiopulmonary Resuscitation (ECPR) in Adults

Rates of survival with functional recovery for both in-hospital and out-of-hospital cardiac arrest are notably low. Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a modality to improve prognosis by augmenting... read more

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19

An overall good trial that supports the use of high flow oxygen therapy in patients with Severe COVID-19. Randomized controlled trial conducted across three centers in Columbia over 5 months from August 2020 to January... read more

Targeted Temperature Management in Adult Cardiac Arrest

Targeted Temperature Management in Adult Cardiac Arrest

Among adult patients with cardiac arrest, the use of targeted temperature management at 32–34 °C, when compared to normothermia, did not result in improved outcomes in this meta-analysis. There was no effect of initiating... read more

Loading and Increasing Vancomycin Dose Frequency Not Advantageous for Gram-Positive Sepsis in Infants

Loading and Increasing Vancomycin Dose Frequency Not Advantageous for Gram-Positive Sepsis in Infants

The efficacy of a vancomycin loading dose with more frequent dosing and shorter duration of treatment was comparable to standard dosing regimens for gram-positive sepsis in infants but with heightened risk for impaired hearing,... read more

Et Tu, Calcium?

Et Tu, Calcium?

We know our core medications for ACLS (epinephrine, amiodarone, lidocaine) but what is the role of other medications, like calcium? We know calcium can be used in the non-ACLS setting for hyperkalemia to prevent or treat... read more

Hypothermia vs Normothermia for Out-of-Hospital Cardiac Arrest

Hypothermia vs Normothermia for Out-of-Hospital Cardiac Arrest

Hypothermia was first introduced in 2002 by two studies, Bernard et al and The Hypothermia After Cardiac Arrest (HACA) trial. The latter, although a small trial, showed improved neurologic outcomes at six months when patients... read more

High-dose vs. Low-dose Prednisolone in post-COVID-19 Patients

High-dose vs. Low-dose Prednisolone in post-COVID-19 Patients

In some patients, respiratory symptoms and imaging abnormalities persist after acute coronavirus disease 2019 (COVID-19) pneumonia. The chest computed tomography (CT) generally shows diffuse parenchymal lung abnormalities... read more

Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis

Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis

The incidence of postoperative atelectasis was lower in patients undergoing either laparoscopic colectomy or robot-assisted prostatectomy who received pressure support ventilation during emergence from general anesthesia... read more

First-Pass Orotracheal Intubation: Video Laryngoscopy vs. Direct Laryngoscopy

First-Pass Orotracheal Intubation: Video Laryngoscopy vs. Direct Laryngoscopy

Among patients in the ICU requiring intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associated with higher rates of severe life-threatening... read more

Lopinavir-ritonavir and Hydroxychloroquine for COVID-19 Patients

Lopinavir-ritonavir and Hydroxychloroquine for COVID-19 Patients

Recent trials involving steroids and other immunomodulators have shown benefits and contributed to improved care. Given the emerging nature of the virus, several repurposed agents were also considered as potential antiviral... read more

Severe Hyponatremia Management with DDAVP Clamp-Bolus Technique

Severe Hyponatremia Management with DDAVP Clamp-Bolus Technique

The DDAVP clamp technique has considerably simplified the management of severe hyponatremia. The DDAVP clamp was a substantial step forwards in the management of severe hyponatremia. It eliminated a lot of the variability... read more

Safety and Efficacy of MUST-ARDS

Safety and Efficacy of MUST-ARDS

This important first study, using multipotent adult progenitor cells in ARDS patients (MUST-ARDS), was a phase 1/2 randomised, blinded, placebo-controlled trial that demonstrated safety and tolerability of intravenous administration... read more

Effectiveness of Therapeutic Heparin vs. Prophylactic Heparin on COVID-19 Patients

Effectiveness of Therapeutic Heparin vs. Prophylactic Heparin on COVID-19 Patients

In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital wards, therapeutic heparin was not significantly associated with a reduction in the primary outcome but the odds of death at 28 days... read more

Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation. However, there is uncertainty... read more