Septic Distributive Shock: Resuscitative Endovascular Balloon Occlusion of the Aorta

Massive distributive shock can lead to total collapse of the cardiopulmonary system with a subsequent need for CPR. Partial REBOA may be a viable resuscitation adjunct in such cases to restore hemodynamics and increase coronary... read more

Lactate Trajectory Models for Predicting AKI and Mortality in Hyperlactatemia Patients

The present study underscores the significant prognostic value of lactate trajectories in critically ill patients, particularly those with hyperlactatemia. Our findings suggest that rapid lactate clearance is strongly... read more

Hemophagocytic Lymphohistiocytosis Markers Associated with Mortality in Critically Ill Patients

The present study highlights the prognostic significance of HLH criteria in critically ill patients. Individuals exhibiting two or more criteria at ICU admission experienced nearly a doubling in mortality as compared to patients... read more

Clinical Prediction Model Development for Stages of AKI in Critically Ill Patients

Using readily available predictors in the ICU setting, we could develop a prediction model for different stages of AKI with good performance and promising clinical usefulness. Among critically ill patients, acute kidney... read more

Total Bilirubin as a Marker for Hemolysis and Outcome in ARDS Patients Treated with vvECMO

Patients with acute respiratory distress syndrome (ARDS), treatment with veno-venous ECMO and a total bilirubin (tBili) plasma concentration over the threshold of 3.6 mg/dl had significantly lower chances of survival, recovery... read more

The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals

An indispensable resource for physicians, nurse practitioners, physician assistants, pharmacists, and nurses in managing critically ill patients. This comprehensive guide delves deep into the world of vasopressors and inotropes,... read more

The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals

Vasoactive Agents in Cardiogenic Shock Related to AMI and ADHF

Cardiogenic shock (CS) is a heterogeneous condition associated with exceptionally high mortality rates, despite significant advances in the field of cardiology. The primary causes of CS are myocardial infarction-related CS... read more

Methylprednisolone vs. Hydrocortisone in Septic Shock Patients

Corticosteroids play an important role in the management of septic shock patients, especially in those with higher doses of vasopressor. However, the therapeutic benefits of corticosteroids are not limited to hydrocortisone... read more

Machine Learning Model for Predicting Acute Pancreatitis Mortality in the ICU

Machine learning model has been proved to be superior to existing prediction scores for mortality prediction of Acute Pancreatitis (AP). The use of most of previous ML models is limited in clinical practice, mainly due... read more

Impact of Short-Acting Beta-Blockers on the Outcomes of Septic Shock Patients

In patients with septic shock, short-acting beta-blockers may improve survival and reduce new-onset tachyarrhythmias. However, these findings were based on low certainty evidence and given ongoing concerns regarding adverse... read more

Predicting MODS in Trauma-induced Sepsis with Machine Learning Models

The nomogram and machine learning models provide enhanced predictive accuracy for multiple organ dysfunction syndrome (MODS) in trauma-induced sepsis patients compared to traditional scoring systems. These tools, accessible... read more

Code Sepsis – Early Decompensation and Predictors

Early recognition and management of sepsis within the first hour of a sepsis alert is critical for patient survival, requiring healthcare providers to be trained to identify "red flag" symptoms like rapid breathing (tachypnea)... read more

Hemodynamic Monitoring Made Easy: Mastering Critical Care Skills for Nurses and Clinicians

This thorough, simple-to-follow book was created especially for critical care nurses, clinicians, and other healthcare workers to help you fully utilize hemodynamic monitoring. With its straightforward, methodical approach... read more

Hemodynamic Monitoring Made Easy: Mastering Critical Care Skills for Nurses and Clinicians

Clinical Outcomes of Early Phenotype-Desirable Antimicrobial Therapy for Enterobacterales Bacteremia

This is first study to compare clinical outcomes between patients with E coli, K pneumoniae, K oxytoca, and P mirabilis BSIs receiving early PDAT vs delayed PDAT using DOOR analysis. Receiving early phenotype-desirable... read more

IFG vs. CBG in Patients with Multiple Organ Failure Requiring Vasopressor Infusion

Interstitial flash glucose (IFG) does not demonstrate either analytical or clinical accuracy to be considered equivalent to capillary blood glucose (CBG) in patients with multiple organ failure who require vasopressor infusion. This... read more

Prediction of AKI in ICU Patients Based on Interpretable Machine Learning

The machine learning model described in this study is capable of accurately predicting the onset of AKI in ICU patients up to 24 hours in advance. Validated within the MIMIC-IV and MIMIC-III databases, the model demonstrates... read more

Intubate Patients with Sepsis Before Midnight or When the Time Comes?

The ever-recurring decision for every clinician is to act or not to act and when to act. The balance of benefit or harm of an intervention and the optimal timing of treatment is not always clear. Intervening or not and... read more

Fluid Bolus Therapy with 20% Albumin vs. Crystalloid-based Regimen

In this trial involving adult patients undergoing cardiac surgery with cardiopulmonary bypass, 20% albumin fluid bolus therapy (FBT) compared to crystalloid FBT did not decrease the occurrence of acute kidney injury (AKI).... read more

Association Between SHR and Mortality in Patients with Heart Failure Complicated by Sepsis

This study suggests that stress hyperglycemia ratio (SHR) may be a valuable predictor of prognosis in patients with heart failure combined with sepsis. Both high and low SHR values are associated with poorer outcomes.... read more

Rethinking Energy and Protein Provision for Critically Ill Patients

In critically ill patients, we suggest that energy and protein be delivered progressively in stable or recovering patients. If a patient deteriorates, regardless of days spent in the ICU, low-dose energy and protein should... read more

Septic Shock in the Prehospital Setting

Septic shock (SS) is a potential life-threatening condition in which an early identification and immediate therapy stand out as the main cornerstones to improve survival chance; in this context, emergency medical services... read more

Protocolized Fluid Balance Neutralization During CRRT

Bitker et al. report the GO NEUTRAL randomized clinical trial results, which investigated fluid balance neutralization guided by functional hemodynamic monitoring (FHM) protocol versus a standard of care in critically ill... read more