Intravenous High-Dose Magnesium for New-Onset Rapid Atrial Fibrillation in the ICU

New-onset atrial fibrillation (AF) is a frequent complication in the intensive care unit (ICU) and is associated with poorer patient outcomes. Despite international guidelines offering limited recommendations, a growing body... read more

The Long-term Impact of nirsevimab on RSV-related Hospitalizations

Following two consecutive RSV seasons, nirsevimab immunization demonstrated significant protection against severe outcomes. The first season showed a substantial reduction in severe disease, and this protective effect continued... read more

Clot Formation Within Tracheostomy Tube in Surgical Unit

Clotting inside tracheostomy tubes is a major problem that can block the airway and trigger breathing problems, more especially among critical care patients. This clinical audit is a full report of the Tracheostomy Care Practice... read more

Hemodynamic and Neurological Presentations of Invasive Meningococcal Disease in Adults

Neurological and hemodynamic presentation of invasive meningococcal disease (IMD) are clinically and prognostically distinct. Recognition of these phenotypes is critical for appropriate management and prediction of outcome. Of... read more

Gastrointestinal Bleeding in Patients with Antithrombotic Therapy

Patients with anticoagulant therapy more often present with a lower source of GI bleeding than both those on antiplatelet medications and those with no antithrombotics. This should be taken into account when initially evaluating... read more

Heterogenous Treatment Effect of Neuromuscular Blocking Agents for Moderate-to-severe ARDS

The systematic and short-term administration of cisatracurium in patients with moderate-to-severe ARDS appears to confer greater survival benefit in those with a higher baseline life expectancy. Further validation through... read more

Meropenem and Piperacillin/Tazobactam Optimized Dosing Regimens for Critically Ill Patients Receiving RRT

This study provides optimized dosing regimens for meropenem and piperacillin/tazobactam in critically ill patients receiving diverse renal replacement therapy (RRT) prescriptions. Daily dosing is dependent on the target... read more

Critical Care Ultrasonography Usage in the Management of Cardiogenic Shock

Despite advancements in treatment, cardiogenic shock (CS) still has a very high mortality rate. To improve patient outcomes, a timely diagnosis and the correct management are crucial. This is especially true given the changing... read more

Norepinephrine Dosing: A Historical Look at Reporting and Salt Formulations

Reporting on norepinephrine dosage has been inconsistent due to variations in how drug labels account for different salt formulations. This inconsistency creates problems in clinical practice and research by making it difficult... read more

oXiris Treatment Efficacy To Reduce Endotoxin Levels

In this pilot study of patients with CS requiring VA-ECMO, the application of an oXiris did not demonstrate a significant reduction in endotoxin levels at 48 h compared with standard care. While we observed temporal decreases... read more

Improving Hemodynamics in Vasoplegia Septic Shock with Adjunctive Tocilizumab

In pediatric patients with vasoplegia septic shock, adjunctive tocilizumab is associated with improved hemodynamics, shortened shock duration, and reduced mortality. IL-6 may serve as both a biomarker and therapeutic target... read more

Endotracheal Intubation Preoxygenation in Resource-limited Settings

Optimal preoxygenation strategies for endotracheal intubation (ETI) in LRS require both protocol adaptation and clinical resourcefulness. An individualized approach using the most feasible combination of techniques should... read more

Enhancing Early Mortality Prediction for Sepsis-associated ARDS Patients Using Machine Learning

This study utilized the MIMIC-IV, eICU CRD, and NWICU databases to construct and validate a machine learning model, SAFE-Mo, which predicts early mortality in patients with sepsis-associated acute respiratory distress syndrome... read more

Neurally Adjusted Ventilatory Assist Decreases the Requirement of Corticosteroids

This study aimed to evaluate the incidence of bronchopulmonary dysplasia (BPD) and the dosage of corticosteroids in extremely preterm infants with the implementation of neurally adjusted ventilatory assist (NAVA). This... read more

The Influencing Factors of Neonatal Extubation Failure

This study conducted a systematic review and meta-analysis of 22 studies, revealing significant differences in risk factors between the extubation success and failure groups. Subgroup analysis further showed variations in... read more

Increased Driving Pressure During Assisted Ventilation for Hypoxemic Respiratory Failure Is Associated with Lower ICU Survival

Driving pressure is marker of severity and a possible target for lung protection during controlled ventilation, but its value during assisted ventilation is unknown. Inspiratory holds provide an estimate of driving pressure... read more

Restrictive vs. Liberal Transfusion Strategy in Patients with Spontaneous ICH

Red blood cell transfusions are commonly administered to anemic patients with spontaneous intracerebral hemorrhage (ICH); however, the optimal hemoglobin threshold to initiate transfusion is uncertain in this population.... read more

Impact of Low-Dose Ketamine Infusion on Intracranial Pressure and Hemodynamics in Septic Shock Patients

Adult patients with septic shock, on hemodynamic support, had high-to-normal intracranial pressure (ICP). Low-dose continuous ketamine infusion as an adjunct sedative appeared to have favorable outcomes concerning ICP and... read more

Airway Management Success in Out-of-hospital Cardiac Arrest Using Different Devices

Although this study found no significant difference in the FPS rates between direct laryngoscopy and video laryngoscopy, the more frequent use of conventional laryngoscopy was associated with a lower FPS rate among anesthetists.... read more

The Role of Neuroimaging in Brain Death Diagnosis

Brain death remains a medically and ethically complex topic, due to its religious and philosophical implications, despite the attempt to "scientificise" what is death and what is not. BD is characterized by a lack of universal... read more

Altered Lower Brainstem Neurophysiological Response Is Associated with Mortality In Deeply Sedated Critically Ill Patients

Absent cough reflex is associated with mortality in intensive care unit (ICU) patients requiring deep sedation, suggesting that lower brainstem dysfunction contributes to adverse outcomes. We conducted a multicenter observational... read more

Anticoagulation Management and Outcomes in Critically Ill Patients with Acute Mesenteric Ischemia

This study suggests a significant survival benefit of early full-dose anticoagulation in ICU patients with acute mesenteric ischemia and no difference in hemorrhagic complications. Early full-dose anticoagulation and revascularization... read more