A Perspective on Post-Cardiac Arrest Syndrome
This book presents a valuable new perspective on Post-Cardiac Arrest Syndrome (PCAS), which was defined as system failure following whole-body ischemia-reperfusion injuries by the 2008 International Liaison Committee on Resuscitation.... read more
Hypothermic Cardiac Arrest: Prognostic Factors for Successful Resuscitation Before Rewarming
Patients with core body temperature ... read more
Protocolized Fluid Balance Neutralization During CRRT
Bitker et al. report the GO NEUTRAL randomized clinical trial results, which investigated fluid balance neutralization guided by functional hemodynamic monitoring (FHM) protocol versus a standard of care in critically ill... read more
Relationship between Concentrations of Oxygen and Levels of Oxidative Stress in Patients Receiving Oxygen Therapy for Severe COVID-19 Pneumonia
We evaluated the potential of high-flow oxygen therapy to increase oxidative stress and inflammation in COVID-19 patients. Our observation of decreased MDA levels when transitioning hypertensive patients from high-flow to... read more
Preventing VAP Non-Pharmacologically
In critically ill, intubated patients on intensive care unit (ICU), ventilator-associated pneumonia (VAP) is a significant complication contributing to substantial mortality, morbidity, and prolonged stays, which in turn... read more
ARDS and Prone Positioning
Prone positioning has been a treatment option for acute respiratory distress syndrome in critically ill patients. Since the COVID-19 pandemic, awake prone positioning has been utilized as a treatment option for non-intubated... read more
Management of Refractory COPD
Chronic obstructive pulmonary disease (COPD) is a common condition with an estimated global prevalence of almost 12 percent in adults over age 30 years [1-3]. Prior to the onset of the COVID-19 (coronavirus disease 2019)... read more
How I Perform Diaphragmatic Ultrasound in the ICU
The diaphragm is a thin, dome-shaped muscle, comprising a costal and crural part, and a non-contracting central tendon. Muscle fiber activation shortens and thickens the diaphragm in the zone of apposition, moving the dome... read more
The Paracetamol Challenge in ICU
Paracetamol is one of the most widely prescribed medications in critically ill patients. Our intensive care unit (ICU) administered 50.133 g of paracetamol in 2023 (16.230 intravenous [IV] doses, 33.825 oral doses and 78... read more
Spontaneous Breathing Trials Should Be Adapted for Each Patient According To The Critical Illness
Unassisted SBTs, namely PSV0PEEP0 and T-piece trial, are the most appropriate to replicate the postextubation effort to breathe. In this multicentre randomized cross-over study, adult intensive care unit patients under... read more
Managing Blood Glucose Control in the ICU
Current evidence supports avoiding iatrogenic factors that aggravate hyperglycemia, such as early-PN and liberal corticosteroid use, and does not support TGC, except with accurate tools and protocols that prevent iatrogenic... read more
Invasive Fungal Infections in Non-neutropenic Patients
Critically ill patients, particularly those with features of immunosuppression, are susceptible to invasive fungal infections (IFI), which pose significant diagnostic and therapeutic challenges. Candida and Aspergillus,... read more
Microbial Dynamics and Pulmonary Immune Responses in COVID-19 Secondary Bacterial Pneumonia
Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated... read more
Comprehensive Tracheostomy Care: The National Tracheostomy Safety Project Manual (Advanced Life Support Group)
Comprehensive Tracheostomy Care is a resource developed by the UK National Tracheostomy Safety Project (NTSP) to help promote and facilitate the safe management of tracheostomies and laryngectomies. The scope includes... read more
Outcomes and inflammation changes in different types of immunocompromised patients with critically ill COVID-19 admitted to ICU
Critically ill COVID-19 patients admitted to the ICU exhibit distinct clinical outcomes based on their immunosuppression status, with cancer patients facing the highest mortality rate due to variations in inflammatory responses... read more
Pulmonary Barotrauma in COVID-19 Patients: Experience From a Tertiary University Hospital
Mechanical ventilation (MV) in COVID-19 patients is often complicated with pulmonary barotrauma. The aim of this study was to determine the incidence and risk factors associated with the development of pulmonary barotrauma... read more
Delirium and Weakness Acquired in the ICU: Individual and Combined Effects on 90-Day Mortality in Survivors of Critical Illness
Mortality is substantially high among critically ill survivors who experience both delirium and weakness, although no additive effect on mortality was observed when these conditions occur together. Our findings highlight... read more
COVID-19 Leaves Lasting Impact on Nursing Practices and Job Satisfaction
The COVID-19 pandemic exacerbated the difficulties nurses experience, especially in emergency departments, requiring adjustments in practice care settings and continuing to impact their overall job satisfaction. Nursing... read more
Tracheostomies The Complete Guide
Tracheostomies: The Complete Guide (2nd ed.) serves as a comprehensive resource for healthcare practitioners and patients navigating the complexities of tracheostomy and laryngectomy care. This edition emphasizes the... read more
A Blueprint for Change in Acute and Critical Care Nursing
A new article from Penn Nursing faculty proposes a significant shift in how nursing care is measured within acute and critical care settings by recognizing the full scope of a nurse's work and its impact on patient outcomes. The... read more
COVID-19 and the Cardiovascular System: From Pathophysiology to Clinical Management
COVID-19 and the Cardiovascular System: From Pathophysiology to Clinical Management comprehensively covers COVID-19's impact on the cardiovascular system. Coverage includes the pathophysiology, clinical manifestations, diagnostic... read more
Microbiological Profile of Hospital Infections in ICUs
Hospital-acquired infections are a serious public health problem, leading to increased morbidity and mortality among patients admitted to intensive care units, complications related to health care, as well as longer hospital... read more
