Myopericarditis Following COVID-19 Vaccination and Non-COVID-19 Vaccination
The overall incidence of myopericarditis from 22 studies (405,272,721 vaccine doses) was 33·3 cases (95% CI 15·3–72·6) per million vaccine doses, and did not differ significantly between people who received COVID-19... read more
Science and Practice of Pediatric Critical Care Medicine
The field of critical care medicine is in the midst of a dramatic change. Technological and scientific advances during the last decade have resulted in a fundamental change in the way we view disease processes, such as sepsis,... read more
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19
Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. The... read more
External Chest-wall Compression in Prolonged COVID-19 ARDS with Low-compliance
SARS-CoV-2 can lead to severe respiratory failure (C-ARDS) with some clinical and radiological characteristics that match the presentation of acute respiratory distress syndrome (ARDS). The management of mechanical ventilation... read more
Damage Control in Trauma Care: An Evolving Comprehensive Team Approach
This book describes current, evidence-based guidelines for damage control interventions across the field of trauma care with the aim of enabling clinicians to apply them to best effect in daily clinical practice. Emphasis... read more
The impact of physical medicine and rehabilitation consultation on clinical outcomes in the SICU
The impact of a physical medicine and rehabilitation (PM&R) consultation on clinical outcomes in critically ill surgical patients remains unclear. The aim of this study is to examine whether the patients who received PM&R... read more
Probiotics for the Prevention of Ventilator-Associated Pneumonia
Presently, there is conflicting evidence regarding the efficacy of probiotics in the prevention of ventilator-associated pneumonia (VAP). This meta-analysis was conducted to update current clinical evidence and evaluate the... read more
Prevalence of COVID-19-Associated Pulmonary Aspergillosis
First reports of cases and case series of COVID-19-associated pulmonary aspergillosis (CAPA) emerged during the first months of the pandemic. Prevalence rates varied widely due to the fact that CAPA was, and still remains,... read more
Physiological Responses to In-Bed Cycle Ergometry Treatment in ICU Patients with External Ventricular Drainage
These data suggest that supine CE in a heterogeneous cohort of neurocritical care patients with EVDs is safe and tolerable. Larger prospective studies are needed to determine the efficacy and optimal dose and timing of supine... read more
PPIs Should Not Be Prescribed for Upper GI Bleeds
The topic of PPIs for upper GI bleeds was one of the first posts on First10EM. There is no new evidence, and the bottom line is the same (just don’t use them), so if you are a long time reader, you can probably skip this... read more
Long-term Outcomes of Hospital Survivors Following an ICU Stay
Australian patients admitted to ICU who survive to discharge have worse long-term survival than the general population, except for the elderly admitted to ICU following cardiac surgery. These findings may assist during goal-of-care... read more
Principles of Critical Care
Quickly and accurately diagnose and treat the critically ill patient with guidance from the field's definitive text. Considered the field's definitive text, Principles of Critical Care offers unmatched coverage of the diagnosis... read more
How Autoimmune Disease Risks Increases After COVID-19
The link between COVID-19 infection and development of autoimmune disease is becoming more pronounced, and fields including dermatology are seeking answers to what drives it all. A late-breaking session at the American... read more
Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia
Airway infection is a major cause of mortality worldwide. The identification of new mechanisms aiding in effective host immune response is therefore required. Here, we show that the specific depletion of the pleural immune... read more
tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?
How do you define a last-ditch effort to save someone's life from COVID-19? Perhaps giving tPA to a severe COVID patient? At this point, I am certain many of us have attempted, with informed consent of course, therapies for... read more
Thromboinflammation and Antithrombotics in COVID-19
Thrombotic complications of SARS-CoV-2 infection were recognized early in the pandemic, when infected patients often presented with abnormal coagulation findings and acute macrovascular obstruction, and evidence of pulmonary... read more
Pulse Oximetry Waveform: A Non-invasive Physiological Predictor for the ROSC During CPR
Pulse oximetry plethysmography (POP) may be a novel and effective method for predicting return of spontaneous circulation (ROSC) during resuscitation, with a prognostic value similar to ETCO2 at early stage. 150 out-of-hospital... read more
Use of ECMO in Acutely Poisoned Pediatric Patients in US
Extracorporeal Membrane Oxygenation (ECMO) may improve the hemodynamic and metabolic status of poisoned pediatric patients. Persistent hypotension, acidemia/acidosis, and elevated Pao2 after 24 hours of ECMO were associated... read more
High Dose Insulin and Euglycemia Therapy for Beta-adrenergic Receptor Treatment and Calcium Channel Antagonists Overdose
High dose insulin with dextrose supplementation is indicated for patients with calcium channel blocker and beta blocker overdose and signs of cardiac toxicity. Mechanisms are not completely elucidated, but mostly related... read more
Hemodynamic Management Challenges of Septic Shock
Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ dysfunction, caused by dysregulated host response to infection (Singer et al. 2016). Septic shock... read more
Moderate Procedural Sedation and Analgesia
Introducing the definitive resource designed for practitioners working in the rapidly expanding area of moderate procedural sedation and analgesia clinical practice. Moderate Procedural Sedation and Analgesia: A Question... read more
General Anesthesia vs. Sedation Using Hemodynamic Control During Intraarterial Treatment for Stroke
The functional outcomes 3 months after endovascular treatment for stroke were similar with general anesthesia and sedation. Our results, therefore, suggest that clinicians can use either approach. Of 351 randomized patients,... read more
