Pandemic Triggers Mass Exodus of Critical Care Nurses
Australian hospitals are experiencing a mass exodus of experienced critical care nurses as the COVID-19 pandemic stretches healthcare workers unlike ever before, prompting medical colleges to warn of a workforce crisis. Australian... read more
Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant
Among patients undergoing LT, use of iEPO was associated with similar risks for PGD-3 development and other postoperative outcomes compared with the use of iNO. A total of 201 randomized patients met eligibility criteria... read more
Dynamic Delirium Severity Trajectories and Healthcare Utilization
This secondary analysis did not identify a significant relationship between delirium severity trajectories and healthcare utilization or mortality within 2 years of hospital discharge. The overall sample (n = 431) had... read more
Anti-interleukin Drugs Effect on COVID-19 Patients
Drugs targeting IL-1 or IL-6 did not shorten the time to clinical improvement in this sample of patients with COVID-19, hypoxic respiratory failure, low SOFA score, and low baseline mortality risk. Between April 4, and... read more
Weaning Methods From Mechanical Ventilation in Adult Patients
In general consideration, our study provided evidence that weaning with proportional assist ventilation has a high probability of being the most effective ventilation mode for patients with mechanical ventilation regarding... read more
The Exciting Future of Our Physical Exam with POCUS
Point-of-care ultrasound (POCUS) is the natural progression of what Laennec started over 200 years ago, a tool he would undoubtedly add to his diagnostic repertoire were he able to, as he did with Auenbrugger’s percussion... read more
Optimizing Critical Illness Recovery: Perspectives and Solutions From the Caregivers of ICU Survivors
This qualitative, multicenter, international study of caregivers of critical illness survivors identified consistently unmet needs, means by which caregivers accessed support post ICU, and several care mechanisms identified... read more
Head Rotation in Anaesthetised Apnoeic Patients Significantly Increases Mask Ventilation Efficiency
Head rotation of 45° in anaesthetised apnoeic adults significantly increases the efficiency of mask ventilation compared with the neutral head position. Head rotation is an effective alternative to improve mask ventilation... read more
Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest
Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation. However, there is uncertainty... read more
Ivermectin Not the Crisis It’s Claimed to Be
I can't remember any time when the U.S. Food and Drug Administration had to resort to the faux-folksy mode of expression to try to get its point across. We live in strange times. The FDA was responding, of course, to the... read more
Use of Hemoadsorption in Patients With Severe Intoxication Requiring ECMO
Drugs intoxications often lead to severe vasoplegia and cardiogenic shock, and VA-ECMO represents a viable therapy option. However, as cardiopulmonary support is not contributing to the removal of the causal agent from the... read more
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role... read more
Year of the Nurse: A 2020 Covid-19 Pandemic Memoir
This book is for everyone, nurse or otherwise, who is furious about how 2020 went down and how 2021 is going. #1 Amazon Bestseller in Critical & Intensive Care Nursing #1 Amazon Bestseller in Mental Health Nursing #1... read more
Endothelial Glycocalyx Degradation Contributes to Metabolic Acidosis in Children After Cardiopulmonary Bypass Surgery
Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary... read more
Critical Illness in Patients with Hematologic Malignancy
Critical illness in patients with a newly diagnosed hematologic malignancy is frequent, occurring early after diagnosis. Certain baseline characteristics can help identify those patients at the highest risk. A total of... read more
Adrenal Insufficiency in Patients Taking Benralizumab as Corticosteroid Sparing Therapy
A personalised regimen of tapering oral corticosteroids in the presence of the anti-IL5 receptor α-directed cytolytic monoclonal antibody benralizumab can help to achieve elimination or dose reduction of oral corticosteroids... read more
Effect of Adjunctive Vitamin C, Glucocorticoids, and Vitamin B1 on Sepsis
We aimed to compare the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock. MEDLINE, Embase, CENTRAL, ClinicalTrials.gov... read more
Acute Eosinophilic Pneumonia Secondary to Daptomycin
Daptomycin is an antimicrobial agent with activity against gram-positive bacteria that is usually reserved for severe infections. Acute eosinophilic pneumonia (AEP) is an increasingly rare side effect that can manifest after... read more
Seven Signs of Life: Stories from an Intensive Care Doctor
Seven Signs of Life encompasses intensive care stories centered around patients and as a means to explain the ICU to the non-clinician. However, Aoife Abbey organises her book by emotion, not by body system. This clever structure... read more
How protein-based COVID vaccines could change the pandemic
Unlike the relatively new technologies that the mRNA and viral-vector COVID-19 shots are based on, protein vaccines have been used for decades to protect people from hepatitis, shingles and other viral infections. To... read more
Not all COVID waves look the same. Here’s a snapshot of the Delta surge
Waves of Covid can give you an awful sense of déjà vu. As "Hot Vax Summer" gave way early to Delta-anxious fall, you could be forgiven for feeling a familiar sense of dread, not so different from what you’d felt before... read more
One Night in the ER
Follow Dr. Jim McCray through a single twelve-hour night shift working in the emergency room of a small Midwestern hospital. The fast-paced writing chronicles Dr. McCray's experience with wit and candor as he manages... read more
