ARDS vs. PseudoARDS – Failure of the Berlin Definition

True ARDS might be defined as a histological diagnosis involving diffuse alveolar damage throughout the lungs (characterized by hyaline membrane formation and thickening of the alveolar walls). PseudoARDS refers to patients... read more

Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic

The ongoing pandemic could affect the duration, variety and severity of the mental, physical, and cognitive impairments intensive care unit (ICU) survivors and their families frequently present. We aim to determine the impact... read more

The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks

Our data suggest that the sepsis risk stratification tools currently utilized in emergency departments and on the general wards do not predict mortality adequately. This is illustrated by the disparity in mortality risk... read more

Neurological Complications After First Dose of COVID-19 Vaccines

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate... read more

The Nexus Between Sleep Disturbance and Delirium Among Intensive Care Patients

Sleep in intensive care is hampered due to many factors; the clinical environment itself exacerbates sleep disturbance. Research suggests that interventions aimed at improving sleep quality have produced positive effects... read more

Prehospital FAST Reduces Admission Time and Treatment

The focused assessment with sonography in trauma (FAST) exam is an established trauma care diagnostic procedure. Ultrasound performed during prehospital care can improve early treatment and management of the patients. According... read more

Diaphragm Dysfunction After Cardiac Surgery

Symptomatic diaphragmatic dysfunction was found in 7.6% of patients after cardiac surgery. It led to an increase of respiratory complications, such as pneumonia, prolonged ventilation, and intensive care. Coronary bypass... read more

COVID-19 and Critical Illness Neuropathy

We have described COVID patients in the ICU with critical illness neuropathy (CIP). COVID-related CIP could have implications for the functional recovery and rehabilitation strategies. Nerve conduction studies showed a... read more

Kidney Imaging with Point-of-Care Doppler Ultrasonography

We read with great interest the article by Caroli et al., in which they meticulously discuss the role of imaging in elucidating both structural and functional aspects of kidney disease. Herein, we would like to briefly comment... read more

Changes in Barriers to Implementing Early Mobilization in the ICU

This study was undertaken to investigate the rate of mobilization, defined as a rehabilitation level of sitting on the edge of a bed or higher, and its association with changes in barriers in the intensive care unit (ICU).... read more

Interhospital Transfer of COVID-19 Patients Treated with High-flow Nasal Oxygen Therapy

At the start of the COVID-19 pandemic, early intubation was recommended on the basis of worldwide observations of severe hypoxemia. However, some patients were ultimately able to benefit from high-flow nasal cannula (HFNC)... read more

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest

In comatose survivors of out-of-hospital cardiac arrest, a target temperature of 31 °C did not significantly reduce the rate of death or poor neurologic outcome at 180 days compared with a target temperature of 34 °C. However,... read more

Emerging Advances have the Potential to Change the Future of Sepsis Care

In recent years, many advances in the sepsis literature have occurred, including new definitions, changes to the Surviving Sepsis Campaign (SSC) bundles, new pharmacologic agents, and adjunct treatments. There are also... read more

Pre-hospital suPAR, Lactate and CRP Measurements for Decision-making

Pre-hospital suPAR measurements alone or combined with C-reactive protein (CRP) and/or lactate measurements could not predict the ED discharge or hospital admission of 109 non-urgent EMS patients with non-specific chief complaints... read more

CCSC Encourage Flu Shots Amid COVID-19 Spread

The members of the Critical Care Societies Collaborative (CCSC), which includes the American Association of Critical-Care Nurses (AACN), American College of Chest Physicians (CHEST), American Thoracic Society (ATS), and Society... read more

Pulmonary Artery Catheterization in Patients with Cardiogenic Shock

Very low-quality observational evidence suggests pulmonary artery catheterization (PAC) use in patients with cardiogenic shock is associated with lower mortality. Overall, these results support consideration of PAC for... read more

Carbapenem Antibiotics for the Empiric Treatment of Nosocomial Pneumonia

Carbapenem-based empiric regimens were associated with lower mortality rates compared with non-carbapenems, largely driven by trials of ventilator-associated pneumonia (VAP). The mortality effect was not observed in trials... read more

Perioperative Dexmedetomidine on the Incidence of Postoperative Delirium

Delirium occurs commonly following major non-cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive dysfunction; increased length of hospital stay; and major postoperative... read more

COVID-19: Restricted Visitation Policies in Acute Care Settings

Patients, families, and healthcare professionals were impacted by restricted visitation polices in acute care settings during COVID-19. The consequences of this approach on patients and families are understudied and warrant... read more

Brain–lung Interactions and Mechanical Ventilation in Patients with Isolated Brain Injury

During the last decade, experimental and clinical studies have demonstrated that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs... read more

Timing of Antibiotic Therapy in the ICU

Severe or life threatening infections are common among patients in the intensive care unit (ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial therapy for clinical resolution. Antibiotics... read more

Short-term and Long-term Rates of Postacute Sequelae of COVID-19 Infection

In this systematic review, we evaluated the temporal progression of clinical abnormalities experienced by patients who recovered from an infection with SARS-CoV-2, starting with a mean of 30 days post–acute illness and... read more