Tag: anticoagulation
Unfractionated Heparin May Improve Near-term Survival in ICU Patients with Sepsis Pneumonia
This study found that early administration of heparin, particularly in sufficient doses (Heparin Sodium 5000 units/mL, 1 mL per dose, three times daily (TID)) for more than 7 d, was associated with reduced near-term mortality... read more
Anticoagulation Among COVID-19 Patients
In this prospectively designed meta-analysis of randomized trials, administration of therapeutic- compared with prophylactic-dose anticoagulation with heparins to patients hospitalized for COVID-19 was associated with 23%... read more
Atrial Fibrillation Status and Associations with Adverse Clinical Outcomes in COVID-19 Patients
COVID-19 patients with atrial fibrillation (AF) are at high risk of adverse clinical outcomes. Such patients may need increased surveillance and consideration for early anticoagulation. Patients admitted with COVID-19... read more
Citrate Anticoagulation for CRRT
Regional citrate anticoagulation (RCA) is a viable option for liver failure patients. The pro-posed inducible metabolic pathway hypothesis challenges the belief in hepatic dominance over citrate metabolism during RCA-CRRT.... read more
Workbook on Renal Replacement Therapy in ICU (ISCCM)
This workbook focuses on renal replacement therapy in ICU. The incidence of acute kidney injury in critically ill patients is increasing steeply. Acute kidney injury in this setting is associated with high morbidity and mortality.... read more
Anticoagulation in the ICU: Contact Pathway Inhibition Future
Bleeding and thrombotic complications are the main cause of morbidity and mortality in critically ill patients on the intensive care unit (ICU), receiving short-term percutaneous mechanical circulatory support (pMCS) by extracorporeal... read more
Early Control of Elevated Blood Pressure – INTERACT3
Early control of elevated blood pressure is the most promising treatment for acute intracerebral hemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols for early intensive... read more
Prostacyclin Anticoagulation Efficacy in Critically Ill Patients Requiring Extracorporeal Support
Extracorporeal support modalities are highly prothrombotic. Anticoagulation is frequently used for patients receiving Continuous Renal Replacement Therapy (CRRT), Molecular Adsorbent Recirculating System (MARS), and Extracorporeal... read more
Thrombotic and Bleeding Complications During Antithrombotic Treatment
Remarkable progress has been made in the pharmacological management of patients with cardiovascular disease, including the frequent use of antithrombotic agents. Nonetheless, bleeding complications remain frequent and potentially... read more
Atrial Fibrillation and Ischemic Stroke Patients While on Oral Anticoagulation
Patients with Atrial Fibrillation (AF) and ischemic stroke while on oral anticoagulation are at increased risk of recurrent ischemic stroke and death. These patients currently have an unmet medical need. Individual participant... read more
Heparin-based vs. Bivalirudin-based Anticoagulation in Pediatric ECMO
Bivalirudin may be a safe, cost-effective alternative to heparin in achieving anticoagulation in pediatric extracorporeal membrane oxygenation (ECMO) patients. Prospective multicenter studies and randomized control trials... read more
Algorithm to Predict Thromboembolism in COVID-19 Patients
Patients with COVID-19 are at increased risk for thrombosis and might be stratified on admission based on lower Pao2/FiO2 ratio, higher D-dimer levels and history of major hemorrhages. 64 thromboses were recorded in 54... read more
Trauma-induced Coagulopathy
Trauma is a major cause of mortality worldwide, and bleeding is the leading preventable cause of death. About one-quarter of patients with severe trauma develop a clotting disorder termed trauma-induced coagulopathy (TIC)... read more
Plasma Exchange in the ICU
In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement... read more
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19
Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. The... read more
tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?
How do you define a last-ditch effort to save someone's life from COVID-19? Perhaps giving tPA to a severe COVID patient? At this point, I am certain many of us have attempted, with informed consent of course, therapies for... read more
Reducing Mortality in Acute Kidney Injury
This book describes the techniques, strategies, and drugs that have been demonstrated by at least one paper published in a peer-reviewed journal to significantly influence survival in patients with or at risk for acute kidney... read more
Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients
Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32)... read more
Anticoagulation in COVID-19 Patients
Clinical, laboratory, and autopsy findings support an association between COVID-19 and thromboembolic disease. Acute COVID-19 infection is characterized by mononuclear cell reactivity and pan-endothelialitis, contributing... read more
Anticoagulation Post-Discharge in Patients Hospitalized Secondary to COVID-19
This study contains interesting data that could contribute to the standard of practice when treating patients after hospitalization for COVID-19. However, use caution when applying the results of this study. Several problems... read more
Bivalirudin vs. Heparin for Maintenance Systemic Anticoagulation During ECMO
When compared with heparin-based systemic anticoagulation, bivalirudin demonstrated feasibility and safety as established by the absence of increases in identifiable adverse outcomes while manifesting substantial improvements... read more
