Tag: coagulation
Distinct Immune Profiles and Clinical Outcomes in Sepsis Subphenotypes Based on Temperature Trajectories
Sepsis subphenotypes identified using the universally available measurement of body temperature had distinct immune profiles. Hypothermic patients, who had the highest mortality rate, also had the lowest levels of most pro-... read more
Citrate Anticoagulation for CRRT
Regional citrate anticoagulation (RCA) is a viable option for liver failure patients. The pro-posed inducible metabolic pathway hypothesis challenges the belief in hepatic dominance over citrate metabolism during RCA-CRRT.... read more
Uncovering Heterogeneity in Sepsis
Among critically ill patients with sepsis, subtype strategies using clinical, biomarker, and transcriptomic data do not identify comparable patient populations and are likely to reflect disparate clinical characteristics... read more
Platelets and Fibrinogen Matter When Bleeding on ECMO
Fibrinolysis is poorly investigated in ECMO patients, partly due to a lack of routine laboratory tests evaluating fibrinolysis. Hence, hyperfibrinolysis may be a contributor to bleeding risk during ECMO treatment. However,... read more
Endotoxin Role in Septic Shock
Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop sepsis with very high endotoxin activity... read more
COVID-19 Critical and Intensive Care Medicine Essentials
This book provides healthcare professionals in Critical Care setting an easy consultation guide to fight against COVID-19. The book is divided into sections: Fundamentals of COVID-19, Pneumological critical care, Neurological... read more
Plasmodium Vivax Presenting with Septic Shock and Disseminated Intravascular Coagulation
Malaria has various causative agents that can have a spectrum of disease manifestations, some potentially fatal. Various species have been established as etiologies of malaria, though our understanding of the severity of... read more
Disseminated Intravascular Coagulation in COVID-19 Setting
Disseminated intravascular coagulation (DIC) is an acquired syndrome that can lead to catastrophic thrombosis and hemorrhage. In DIC, an uncontrolled release of pro-inflammatory mediators activates tissue factor-dependent... read more
Atrial Fibrillation and Ischemic Stroke Patients While on Oral Anticoagulation
Patients with Atrial Fibrillation (AF) and ischemic stroke while on oral anticoagulation are at increased risk of recurrent ischemic stroke and death. These patients currently have an unmet medical need. Individual participant... read more
Algorithm to Predict Thromboembolism in COVID-19 Patients
Patients with COVID-19 are at increased risk for thrombosis and might be stratified on admission based on lower Pao2/FiO2 ratio, higher D-dimer levels and history of major hemorrhages. 64 thromboses were recorded in 54... read more
Trauma-induced Coagulopathy
Trauma is a major cause of mortality worldwide, and bleeding is the leading preventable cause of death. About one-quarter of patients with severe trauma develop a clotting disorder termed trauma-induced coagulopathy (TIC)... read more
Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients
Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32)... read more
Cluster ICU Treatment Strategies for TBI by Hospital Treatment Preferences?
Although correlations between treatment policies within domains were found, the failure to cluster hospitals indicates that a specific treatment choice within a domain is not a proxy for other treatment choices within or... read more
d-dimer and Death in COVID-19 Patients
In this multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs across the United States, higher d-dimer was independently associated with a greater risk of death. The added value of d-dimer in... read more
Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid
Combinations of coagulation factor concentrates suspended in albumin solutions can restore thromboelastometry parameters in the absence of plasma. This kind of artificial colloid fluids with coagulation-restoring characteristics... read more
The Blood-Clot Problem Is Multiplying
For weeks, Americans looked on as other countries grappled with case reports of rare, sometimes fatal blood abnormalities among those who had received the AstraZeneca vaccine against COVID-19. That vaccine has not yet... read more
Endothelial Activation and Dysfunction in COVID-19
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization. As of 4 August 2020, more than 18 million confirmed infections had been reported globally. Most... read more
