Tag: coronavirus
tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?
How do you define a last-ditch effort to save someone's life from COVID-19? Perhaps giving tPA to a severe COVID patient? At this point, I am certain many of us have attempted, with informed consent of course, therapies for... read more
Thromboinflammation and Antithrombotics in COVID-19
Thrombotic complications of SARS-CoV-2 infection were recognized early in the pandemic, when infected patients often presented with abnormal coagulation findings and acute macrovascular obstruction, and evidence of pulmonary... read more
Risks and Burdens of Incident Diabetes in Long COVID
In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who were enrolled during... read more
Comparative analysis of the risks of hospitalisation and death associated with COVID-19 variants in England
The risk of severe outcomes following SARS-CoV-2 infection is substantially lower for omicron than for delta, with higher reductions for more severe endpoints and significant variation with age. Underlying the observed risks... read more
Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality
Current guidelines recommend use of dexamethasone, 6 mg/d, up to 10 days or until discharge for patients hospitalized with COVID-19. Whether patients who received less than 10 days of corticosteroids during hospitalization... read more
Sotrovimab Effect Among High-risk COVID-19 Patients
Among nonhospitalized patients with mild to moderate COVID-19 and at risk of disease progression, a single intravenous dose of sotrovimab, compared with placebo, significantly reduced the risk of a composite end point of... read more
Critically Ill Pregnant Women with COVID-19: Management and Outcome
Coronavirus disease 2019 (COVID-19)-infected pregnant women are at higher risk of intensive care unit (ICU) admission and mechanical ventilation. Because reports describing the clinical course and management of critically... read more
Clinical, Biological and Molecular Aspects of COVID-19
The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the... read more
Indicators for Monitoring COVID-19 Community Levels and Making Public Health Recommendations
Widespread uptake of COVID-19 vaccines that are highly effective against severe illness and death, the accrual of high rates of vaccine- and infection-induced immunity at the population level, and the availability of effective... read more
Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill
As remarked by the authors of the recent PLUS trial, a systematic review and meta-analysis of randomized controlled trials comparing balanced resuscitation fluid to 0.9% saline was reported in the New England Journal of Medicine... read more
Palliative Care Consultation and End-of-life Outcomes in Hospitalized COVID-19 Patients
Palliative care consultation was not associated with CPR performed at the end-of-life but was associated with increased incidence of comfort care being utilized. These results suggest that utilizing palliative care consultation... read more
Anticoagulation in COVID-19 Patients
Clinical, laboratory, and autopsy findings support an association between COVID-19 and thromboembolic disease. Acute COVID-19 infection is characterized by mononuclear cell reactivity and pan-endothelialitis, contributing... read more
Pediatric Pneumonia Research Priorities in the Context of COVID-19
Operational research on health system capacities, and evaluating optimized delivery of existing treatments, diagnostics and case management approaches are needed. This list should act as a catalyst for collaborative research,... read more
3D Printing PPE During COVID-19 Pandemic
Supply chain disruption during the COVID-19 pandemic has forced healthcare systems to look for alternative ways to meet dramatically increased demand for personal protective equipment (PPE). One potential solution to this... read more
POCUS and Digital Tomosynthesis Correlation When Used with COVID-19 Pneumonia Patients
Point-of-care ultrasound (POCUS) in primary care has good sensitivity and specificity when compared to digital tomosynthesis as regards the diagnosis of COVID-19 pneumonia in patients with the clinical suspicion of pulmonary... read more
Clinical Profile and Recovery Pattern of Dysphagia in COVID-19 Patients
COVID-19 considerably impacted swallowing function in the current study. Although many patients recovered within an acceptable timeframe, some experienced persistent severe dysphagia and a protracted recovery with dependence... read more
Cardiovascular Complications of COVID-19: Risk, Pathogenesis and Outcomes
This book discusses the evidence behind the relationship between COVID-19 and heart disease based on emerging state-of-the-art data. The rapid and unexpected global spread of the COVID-19 has revealed proportional levels... read more
Ascending Aortic Thrombus After COVID-19 Infection
SARS-CoV-2 predisposes patients to both venous and arterial thromboembolism, including ascending aortic thrombus. The current guidelines for anticoagulation recommend three to six months of continuous anticoagulation... read more
