Tag: coronavirus
Lactoferrin for the Treatment of COVID‑19
The coronavirus disease 2019 (COVID‑19) outbreak was caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The clinical outcomes of elderly individuals and those with underlying... read more
NIH ACTIV trial of blood thinners pauses enrollment of critically ill COVID-19 patients
Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19... read more
Endothelial Activation and Dysfunction in COVID-19
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization. As of 4 August 2020, more than 18 million confirmed infections had been reported globally. Most... read more
Effective design of barrier enclosure to contain aerosol emissions from COVID-19 patients
Facing shortages of personal protective equipment, some clinicians have advocated the use of barrier enclosures (typically mounted over the head, with and without suction) to contain aerosol emissions from coronavirus disease... read more
Pulse Oximeter Devices Have Higher Error Rate in Black Patients
A study showed that the devices, which measure oxygen levels in the blood, were three times more likely to give misleading readings among African-American patients. Pulse oximeters are one of the most commonly used tools... read more
Azithromycin in Patients Hospitalised with COVID-19
2582 hospitalised patients were randomised to standard of usual care plus azithromycin and 5182 patients received standard of usual care only. Exclusions including patients with long QTc or hypersensitivity to a macrolide... read more
Estimate Death Probabilities of Hospitalized Patients with COVID-19
The Covid-19 pandemic has become a global public health crisis and providing optimal patient care while preventing a collapse of the healthcare system is a principal objective worldwide. Here we describe a formula, requiring... read more
Outcomes Associated with the Use of Renin-Angiotensin-Aldosterone System Blockade in Hospitalized Patients with COVID-19 Infection
Use of ACEI or ARBs prior to hospitalization was not associated with adverse outcomes in COVID-19 and the therapeutic benefits of continuing ACEI or ARB in hospitalized patients with COVID-19 was not offset by adverse outcomes. Data... read more
Decrease in CPR Initiation During COVID-19 Outbreak
During the COVID-19 period, we observed decreased initiation of CPR by bystanders and first aid providers for BLS, and decreased ALS by the MMT, regardless if subjects were infected with SARS-CoV-2 or not. ROSC rates... read more
Adapting to the COVID-19 Pandemic
Thrust into a pandemic unlike any other, health professionals today must continually adapt to an ever-changing environment. Protocols change at dizzying rates, while the physical and mental demands of our jobs increase... read more
ICU Workers Are Quitting Due To Crushing Stress From COVID-19 Surge
As hospitals struggle in Los Angeles County, Intensive Care Unit nurses confront tough choices: remain in the coronavirus trenches for patients and colleagues, or quit when you are overwhelmed? The massive surge in coronavirus... read more
America Is Running Out of Nurses
In normal times, there are some 50,000 travelling nurses in the United States. Most are full-time gig workers who move from job to job, usually staying in one place for thirteen weeks. (That length is a holdover from old... read more
The Emerging Evidence for a Genetic Susceptibility to Severe COVID-19
A defining feature of the COVID-19 pandemic has been the wide spectrum of clinical presentations, ranging from asymptomatic viremia to life-threatening illness. Factors such as advancing age and co-morbid status have been... read more
Genetic Mechanisms of Critical Illness in COVID-19
Host-mediated lung inflammation is present, and drives mortality, in critical illness caused by COVID-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development. Here... read more
Anaesthetists and intensive care doctors are at lower risk of COVID-19 infection compared with other medical staff
Following the first recorded death of an anaesthetist from COVID-19 in the UK in November 2020, a review of available data published in Anaesthesia (a journal of the Association of Anaesthetists) shows that unexpectedly,... read more
Smell test may help spot COVID-19 cases
A scratch-and-sniff screening tool that identifies impaired sense of smell, a common symptom of COVID-19, could help quickly pinpoint cases. Researchers from the University of Colorado in Boulder studied a smell test called... read more
Clinical characteristics of critically ill patients with COVID-19
In this study of critical patients infected by SARS-CoV-2 in a high-complexity hospital, the majority were comorbid elderly men, a large percentage required invasive mechanical ventilation, and ICU mortality was 25%. Design... read more
An Online Tool to Simulate the Effect of Pooled Testing for COVID-19
This diagnostic study describes an online tool created with actual severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus copy number data to help policy makers understand how pooled testing compares with single-sample... read more
Dr. Atul Gawande on why COVID-19 vaccinations will test American society
The distribution of COVID-19 vaccines in America will test a deeply divided society, and not just because of mistrust in vaccinations, Atul Gawande, MD, told New Yorker Editor David Remnick. Dr. Gawande, longtime contributor... read more
