Advances In ICU Care Are Saving More Patients Who Have COVID-19

One thing that has improved a lot over the course of the pandemic is treatment of seriously ill COVID-19 patients in intensive care units. Here's one man's success story. If you think all the coronavirus news is bad, consider... read more

Management of Post-acute COVID-19 in Primary Care

Post-acute COVID-19 ("long covid") seems to be a multisystem disease, sometimes occurring after a relatively mild acute illness. Clinical management requires a whole-patient perspective. This article, intended for... read more

Thrombotic and Hemorrhagic Complications in Critically Ill Patients with COVID-19

Critically ill patients with COVID-19 experience high rates of venous and arterial thrombotic complications. The rates of bleeding may be higher than previously reported and re-iterate the need for randomised trials to better... read more

The Pooled Prevalence of Pulmonary Embolism in Patients with COVID-19

It is needed to pay more attention to the relatively high prevalence of pulmonary embolism (PE) in COVID-19 patients, especially in ICU wards. Future studies that will explore the detection method considering high infectivity... read more

How Severe COVID-19 Infection is Changing ARDS Management

The COVID-19 pandemic has provided many intensivists (and some non-intensivists) several years' worth of severe ARDS management experience over the course of just a few months. While the challenges have, in places, been extreme,... read more

Coagulopathy of COVID-19

Severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019 frequently induces hypercoagulability with both microangiopathy and local thrombus formation, and a systemic coagulation defect that leads to large... read more

ECMO During the Coronavirus Disease 2019 Pandemic

In the midst of the 2009 influenza A H1N1 pandemic, clinicians turned to extracorporeal membrane oxygenation (ECMO) as a strategy to save lives. Based on the H1N1 experience, and the ECMO to Rescue Lung Injury in Severe... read more

Outcomes of COVID-19 Patients Admitted to Australian ICUs During Early Pandemic Phase

During the early phase of the pandemic in Australia, patients admitted to ICU with COVID-19 had lower mortality and longer length of stay than reported from other regions. These findings reinforce the importance of ensuring... read more

Letter Warns Against Clinical Role for Cardiac MRI in Asymptomatic COVID Patients

We are a group of clinicians, researchers and imaging specialists writing in response to recent publications and media coverage about myocarditis after COVID-19. We work in different areas such as public health, internal... read more

Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children

In this cohort study of 315 children with COVID-19 and 1402 children with seasonal influenza, there were no statistically significant differences in the rates of hospitalization, admission to the intensive care unit, and... read more

Pragmatic Approach to Inpatient Diabetes Management During COVID-19

The pandemic of COVID-19 has presented new challenges to hospital personnel providing care for infected patients with diabetes who represent more than 20% of critically ill patients in ICUs. Appropriate glycemic management... read more

From Russia with Love – “Sputnik V” COVID-19 Vaccine Generated an Immune Response

Between June 18 and Aug 3, 2020, Ministry of Health of the Russian Federation enrolled 76 participants to the two studies (38 in each study). In each study, 9 volunteers received rAd26-S in Phase 1, nine received rAd5-S in... read more

Sepsis and COVID-19: Perspectives From a Sepsis Coordinator

Coronavirus disease 2019 (COVID-19) has brought difficulties and disruptions to all corners of the world. As a sepsis coordinator, I can attest that the scientific and healthcare community in the United States has been particularly... read more

COVID-19: A Critical Analysis of Chloroquine and Hydroxychloroquine Clinical Pharmacology

Chloroquine and hydroxychloroquine have been used for over 60 years in the treatment of malaria, amoebic liver abscess, and several rheumatological conditions, but their clinical pharmacology is not well understood. COVID-19... read more

Hydroxychloroquine With or Without Azithromycin

Among patients hospitalized with mild-to-moderate COVID-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. A total of 667 patients... read more

Training Multidisciplinary Healthcare Workers to Reinforce ICUs in Times of Need

ESICM is to carry out a C19 SPACE programme funded by the European Commission for the training of multidisciplinary healthcare professionals not regularly working in ICUs, to give extra support to ICUs during the COVID-19... read more

Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19

Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority... read more

CDC Tells States How to Prepare for Covid-19 Vaccine by Early November

The Centers for Disease Control and Prevention has notified public health officials in all 50 states and five large cities to prepare to distribute a coronavirus vaccine to health care workers and other high-risk groups as... read more

Steroids Confirmed to Help Severely Ill COVID-19 Patients

In patients hospitalized with COVID-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those... read more

Obesity and the Risk of Intubation or Death in Patients with COVID-19

Among consecutive patients hospitalized with coronavirus disease 2019, obesity was an independent risk factor for intubation or death. A total of 305 patients were included in this study. We stratified patients by body... read more

Principles Guiding Non Pandemic Critical Care Research During a Pandemic

Deliberation about continuing non pandemic research should use objective, transparent criteria considering several aspects of the research process such as bedside and research staff safety, infection control, the informed... read more

Asthma Among Hospitalized Patients with COVID-19 and Related Outcomes

Among hospitalized patients 65 years or younger with severe COVID-19, asthma diagnosis was not associated with worse outcomes, regardless of age, obesity, or other high-risk comorbidities. Future population-based studies... read more