Tag: inflammation
Severe Trauma and Sepsis: Organ Damage and Tissue Repair
This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects... read more
Neostigmine’s Anti-Inflammatory Edge: Cholinergic Boost Slashes Cytokines, Organ Failure, and Mortality in Septic Shock
In a randomized controlled trial, researchers investigated the adjuvant use of continuous neostigmine infusion (0.2 mg/hr for 5 days) in patients with septic shock, leveraging its ability to enhance vagal cholinergic anti-inflammatory... read more
Systemic Corticosteroids for Inflammatory Disorders in Pediatrics
This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover... read more
Predicting Sepsis Mortality: The Power of NLR and PCT Clearance
A retrospective cohort study analyzed the dynamic changes of several inflammatory biomarkers to predict mortality in 64 Intensive Care Unit (ICU) patients diagnosed with sepsis. The study, which collected clinical and... read more
Critical Care Anesthesiology
This book is dedicated to the management of the critically ill patient, in particular, the one affected by infectious diseases. The book, thanks to its structure, can be useful both to health professionals already operating... read more
Copine 5: A Key Defender Against Sepsis’s Deadly Leak
This study identifies Copine 5 (CPNE5) as a critical factor in the development of life-threatening sepsis-induced vascular leakage and mortality. Analysis of human aorta cells revealed that CPNE5 is the primary Copine family... read more
Management of Dysregulated Immune Response in the Critically Ill
This book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, deals with dysregulated host response a relatively new term introduced by the Sepsis-3 definitions in 2016. In contrast to systemic... read more
AI Alert: Machine Learning Predicts Septic Shock Early in the ICU
This study developed and successfully validated a machine learning (ML) model designed to provide an early prediction of septic shock in intensive care unit (ICU) patients diagnosed with sepsis. Best Performer: Out of... read more
Sepsis Danger: High Ferritin Levels Flag Risk of Acute Liver Injury
This study used data from the MIMIC-IV database (training group) and an external hospital dataset (clinical validation group) to develop and validate a prediction model for sepsis-associated acute liver injury (SALI). The... read more
ICU Risk Check: Simple Blood Biomarker Predicts Mortality in Heart Attack Patients
A study using data from the MIMIC-IV database investigated the prognostic value of the Neutrophil-Platelet Activity Ratio (NPAR) in critically ill adult patients admitted to the ICU with a first acute myocardial infarction... read more
Sepsis’s Silent Heart Attack: Decoding and Targeting the Multi-Layered Cardiac Failure
This review synthesizes the current understanding of sepsis-induced myocardial dysfunction (SIMD), moving the field beyond supportive care toward precision therapies. While challenges remain in addressing the diverse nature... read more
Why Early mHLA-DR Fails and Dynamic Monitoring is Key to Immunosuppression in Septic Shock
This 20-year study of 1,023 septic shock patients confirms that the immune marker mHLA-DR is a robust biomarker for identifying the most immunosuppressed patients who face a higher risk of death and ICU-acquired infections. The... read more
Individualizing PEEP in Acute Brain Injury
The consensus is that Positive End-Expiratory Pressure (PEEP) can be safely used in most patients with Acute Brain Injury (ABI), provided its effects on the brain are closely monitored. PEEP Safety and ICP: While PEEP... read more
Calming the Storm: Probiotics Significantly Modulate Inflammatory Cytokines in Pediatric Sepsis
This randomized double-blind study investigated the effect of probiotic treatment in children admitted to the pediatric intensive care unit (PICU) with sepsis. Inflammatory Improvement: Probiotic therapy led to a significant... read more
Predicting Mortality in Sepsis-Related ARDS Using Machine Learning
The application of machine learning methodologies to construct prognostic prediction models for sepsis patients complicated by ARDS, informed by the new global definition, proves to be reliable. This approach can assist clinicians... read more
New Sepsis Diagnostic Tool Receives $4.87M Grant to Guide Critical Care
A team of doctors and engineers at Washington University School of Medicine received a $4.87 million grant from the U.S. Department of Defense to create a new, rapid diagnostic device for sepsis. This handheld device will... read more
oXiris Treatment Efficacy To Reduce Endotoxin Levels
In this pilot study of patients with CS requiring VA-ECMO, the application of an oXiris did not demonstrate a significant reduction in endotoxin levels at 48 h compared with standard care. While we observed temporal decreases... read more
Vitamin D Dynamics in Severe ARDS Patients on ECMO
This retrospective study investigated time-dependent changes in vitamin D levels and their correlation with disease severity and inflammation in 24 invasively mechanically ventilated patients with acute respiratory distress... read more
Glycemic Control Role in Inflammation Markers and Clinical Outcomes in Type 2 Diabetes Patients with Severe COVID-19
This study demonstrates that among hospitalized COVID-19 patients with type 2 diabetes mellitus, poor glycemic control (HbA1c ≥ 7%) correlates with increased systemic inflammation, greater disease severity, and worse clinical... read more
Fluid Management Impact on Outcomes in Sequential Extracorporeal Support
Sepsis is a life-threatening condition characterized by dysregulated inflammatory responses, often leading to multiple organ dysfunction and high mortality rates. Continuous renal replacement therapy (CRRT) and extracorporeal... read more
Leptin and Linterlukin-6 Relationship and Influence of Mortality in Sepsis
High leptin levels might counteract the adverse prognostic effect of elevated IL-6 on septic mortality. At the same IL-6 level, leptin could predict septic mortality. Leptin might be a protecting factor for men and gender-different... read more
Predicting Sudden Decrease in Oxygenation in Mechanically Ventilated ICU Patients as a Surrogate Marker for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening form of respiratory failure characterized by widespread lung inflammation that severely impairs oxygenation. Affecting millions of patients worldwide, ARDS... read more
