Balanced Solution vs. 0.9% Saline Solution Fluid Treatment in Critically Ill Patients

Balanced Solution vs. 0.9% Saline Solution Fluid Treatment in Critically Ill Patients

Among critically ill patients requiring fluid challenges, use of a balanced solution compared with 0.9% saline solution did not significantly reduce 90-day mortality. The findings do not support the use of this balanced... read more

Continuous Pneumatic Regulation of Tracheal Cuff Pressure to Decrease VAP in Mechanically Ventilated Patients

Continuous Pneumatic Regulation of Tracheal Cuff Pressure to Decrease VAP in Mechanically Ventilated Patients

Continuous regulation of cuff pressure of the tracheal tube using a pneumatic device was not superior to routine care in preventing Ventilator-associated pneumonia (VAP) in patients with severe trauma. A total of 434 patients... read more

RECOVERY-RS trial finds CPAP reduces need for invasive ventilation in hospitalised COVID-19 patients

RECOVERY-RS trial finds CPAP reduces need for invasive ventilation in hospitalised COVID-19 patients

The NIHR-supported Respiratory Strategies in COVID-19; CPAP, High-flow, and Standard Care (RECOVERY-RS) trial has demonstrated that treating hospitalised COVID-19 patients who have acute respiratory failure with continuous... read more

Discordance Between Respiratory Drive and Sedation Depth in Critically Ill Patients Receiving Mechanical Ventilation

Discordance Between Respiratory Drive and Sedation Depth in Critically Ill Patients Receiving Mechanical Ventilation

Sedation depth is not a reliable marker of respiratory drive during critical illness. Respiratory drive can be low, moderate, or high across the range of routinely targeted sedation depth. 56 patients undergoing 197 bedside... read more

Higher ICU Sepsis Case Volume Associated with Significantly Lower Hospital Mortality

Higher ICU Sepsis Case Volume Associated with Significantly Lower Hospital Mortality

In this cohort study of 273,001 patients with sepsis at 231 ICUs in the UK, a higher annual sepsis case volume in the ICU was associated with significantly lower hospital mortality, and this association had no significant... read more

Reliability of Mechanical Ventilation During Continuous Chest Compressions

Reliability of Mechanical Ventilation During Continuous Chest Compressions

All investigated transport ventilators were able to provide alveolar ventilation even though chest compressions considerably decreased tidal volumes. Our results support the concept of using ventilators to avoid excessive... read more

Artificial Intelligence Hold Promise in the ICU

Artificial Intelligence Hold Promise in the ICU

In a 2018 article entitled “Human Cognitive Limitations”, the University of Utah's Alan Morris estimated the number of variables an intensivist has to take into account for a patient on mechanical ventilation. He... read more

Sedation Practices and Characteristics of Ventilated Patients

Sedation Practices and Characteristics of Ventilated Patients

Patients on mechanical ventilator experience anxiety and physiological stress. Sedating them can help those patients to cope up with ET tube, to bear all the interventions, for accessing adequate oxygenation and above... read more

Inhaled Sedation in the ICU: A New Option and Its Technical Prerequisites

Inhaled Sedation in the ICU: A New Option and Its Technical Prerequisites

Andreas Meiser summarizes the current literature on inhalation sedation of critically ill patients. To meet clinical demands, he describes the development of new devices to administer volatile anesthetics together with common... read more

Diaphragm Ultrasonography in ICU: Why, How, and When To Use It?

Diaphragm Ultrasonography in ICU: Why, How, and When To Use It?

An overview of the principles and current applications of diaphragm ultrasound and innovative ultrasound-based techniques. In the ICU, ultrasound is starting to be acknowledged as a useful tool for studying the diaphragm.... read more

Managing Rising COVID-19 Cases in ICU

Managing Rising COVID-19 Cases in ICU

I have been working in intensive care for over 20 years, including a decade as a consultant, and facing winter pressures has always been the norm. However, the past 18 months have been something else. During the winter... read more

Effects of Early Mobilization on the Prognosis of Critically Ill Patients

Effects of Early Mobilization on the Prognosis of Critically Ill Patients

Early mobilization was effective in enhancing the recovery of critically ill patients, but more large-scale, multicenter randomized controlled trials are required to further confirm these findings. A total of 39 articles... read more

Personalized Mechanical Ventilation in ARDS

Personalized Mechanical Ventilation in ARDS

A personalized mechanical ventilation approach for patients with adult respiratory distress syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging, and biological phenotypes may improve ventilation... read more

Effect of Graded Early Mobilization on Psychomotor Status and Length of ICU Stay in Mechanically Ventilated Patients

Effect of Graded Early Mobilization on Psychomotor Status and Length of ICU Stay in Mechanically Ventilated Patients

This research showed that graded early mobilization was highly effective to improve the motor and psychological status of mechanically ventilated patients and reduce their length of ICU stay. In the control group mean... read more

Prone Positioning and Survival in Mechanically Ventilated Patients with COVID-19

Prone Positioning and Survival in Mechanically Ventilated Patients with COVID-19

In-hospital mortality was lower in mechanically ventilated hypoxemic patients with coronavirus disease 2019 treated with early proning compared with patients whose treatment did not include early proning. Among 2,338 eligible... read more

A Rational Approach on the use of ECMO in Severe Hypoxemia

A Rational Approach on the use of ECMO in Severe Hypoxemia

Veno-venous extracorporeal membrane oxygenation (ECMO) is a helpful intervention in patients with severe refractory hypoxemia either because mechanical ventilation cannot ensure adequate oxygenation or because lung protective... read more

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen therapy and non-invasive ventilation in COVID-19 should be based on pathophysiological changes and a step-by-step approach should be adopted in choosing the right therapeutic strategy for each patient. Continuous... read more