Sex Differences in the Outcome of Critically Ill COVID-19 Patients

Among patients admitted to ICU for severe COVID-19, males experienced higher severity of illness and more frequent intervention than females. Ultimately, the hazard of death was moderately elevated in males compared to females... read more

Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients

In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early... read more

ICU Cardiac Arrest Among Very Elderly Critically Ill Patients

The occurrence of ICU-CA in critically ill patients with advanced age (≥ 90 years) is relatively rare. The observed mortality in the ICU and hospital was exceedingly high. Notably, providing cardiopulmonary resuscitation... read more

Corticosteroid Treatment and Survival in Critically Ill COVID-19 Patients

Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid... read more

Low-Frequency Ventilation May Facilitate Weaning in ARDS Treated with ECMO

Low-frequency ventilation is comparable to conventional protective ventilation in patients with ARDS who have been treated with ECMO. However, low-frequency ventilation may support weaning from invasive mechanical ventilation... read more

A prediction model for nonresponsive outcomes in critically ill patients with ARDS undergoing prone position ventilation

In this study, a risk prediction model for nonresponse to prone position ventilation in acute respiratory distress syndrome (ARDS) patients was constructed, which demonstrated good predictive value and clinical utility. Early... read more

COVID-19 ARDS Patients vs. Patients with ARDS

Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS... read more

Early Reapplication of Prone Position During VV-ECMO for ARDS

A combination of prone positioning (PP) and venovenous extracorporeal membrane oxygenation (VV-ECMO) is safe, feasible, and associated with potentially improved survival for severe acute respiratory distress syndrome (ARDS).... read more

Basics of Mechanical Ventilation

Basics of Mechanical Ventilation

This book is a practical and easily understandable guide for mechanical ventilation. With a focus on the basics, this text begins with a detailed account of the mechanisms of spontaneous breathing as a reference point to... read more

Ventilator-associated Pneumonia Risk Factors in Patients with Severe COVID-19

Patients with COVID-19 are at high risk of VAP, which may be related to issues other than prolonged mechanical ventilation (MV) time. Multiple factors increase the chances of these patients developing VAP, including:... read more

Pitfalls in the Management of Mechanical Ventilation: ARDS and Hypermetabolic States

Mechanical Ventilation (MV) is an invaluable, lifesaving therapy for patients with acute respiratory failure, but it must be individualized for each specific underlying physiologic derangement to maximize benefits and minimize... read more

Pressure Support Ventilation During ECMO Support in Patients with ARDS

In the initial phases of veno-venous extracorporeal membrane oxygenation (VV ECMO) support for severe acute respiratory distress syndrome (ARDS), ultraprotective controlled mechanical ventilation (CMV) is typically employed... read more

Outcomes for Mechanically Ventilated Patients with Acute Myocardial Infarction Admitted to Medical vs Cardiac ICUs

In this multicenter, national analysis of ICU admission for critically ill patients with AMI, we found that admission to the Cardiac Intensive Care Unit (CICU) was associated with lower in-hospital mortality than patients... read more

Efficacy of β-Blockers in Decreasing Mortality in Sepsis and Septic Shock Patients

This study suggests that the use of β-blockers in sepsis and septic shock patients is associated with a significant decrease in in-hospital mortality and also associated with better patient outcomes. As β-blockers cause... read more

Navigating the Complexity of ECMO and Positioning in ARDS Treatment

We read with great interest the network meta-analysis by Sud et al. comparing venovenous extracorporeal membrane oxygenation (VV-ECMO), prone positioning, and supine mechanical ventilation in patients with severe hypoxemic... read more

Antifungal Prophylaxis of COVID-19 Associated Pulmonary Aspergillosis in Ventilated Patients

This study investigated the impact of POSA prophylaxis on risk of CAPA development in mechanically ventilated COVID-19 patients receiving corticosteroids. We observed a significant variation in CAPA incidence rates among... read more

Another Perspective on Tidal Volume: From Statistics to Uncertainty

We have read with great interest the recent editorial by Pellegrini et al. Undoubtedly, now more than ever, we have begun to question the true role of tidal volume (VT) in acute respiratory distress syndrome (ARDS). As... read more