Rapid Clinical Effects of Convalescent Plasma Therapy in Severe COVID-19 ARDS

Administration of convalescent plasma (CP) in critically ill COVID-19 patients leads to a rapid and highly significant improvement of sequential organ failure assessment (SOFA) score along with improvements in respiratory... read more

Promising Prognostic Predictors in Sepsis Patients Using Lactate and Albumin Ratio

Serum Lactate/Albumin ratio and BAR ratio were significantly higher in sepsis and/or septic shock and associated with increased length of hospital stay and increased in-hospital mortality and poor clinical outcome inside... read more

Prophylactic IV Antibiotics Outcomes in Patients with Acute Severe Brain Injury on Mechanical Ventilation

Among critically ill patients with acute brain injury, prophylactic IV antibiotics were associated with less VAP but not with changes in length of stay, mortality, or neurologic outcomes. Patients with structural brain... read more

Association Between Ketamine Use and Mortality in Critically Ill Patients Receiving Mechanical Ventilation

In this retrospective study, we observed that younger patients with acute respiratory distress syndrome (ARDS) may benefit from ketamine use in terms of 14-day mortality. However, these benefits were not observed in longer-term... read more

Peritoneal Dialysis in AKI: 20 Years of Experience at a Single Center

Peritoneal dialysis (PD) may be an effective solution for acute kidney injury (AKI) patients, allowing adequate metabolic and fluid control. Age, APACHE score, hepatorenal syndrome and dropout from PD were associated... read more

Flow Control Ventilation in ICU

Flow control ventilation is an innovative technique of mechanical ventilation with a potentially lung protective characteristics. The constant inspiratory and expiratory flow, no ventilation pauses, and inspiration to... read more

ICU-acquired Weakness: Critical Illness Myopathy and Polyneuropathy

Critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) are significant complications in intensive care unit (ICU) patients, first identified in the late 20th century. These conditions often present... read more

Weaning Failure From Mechanical Ventilation

Ultrasound is a useful tool for identifying weaning failure from cardiovascular, diaphragmatic, respiratory, and airway origin. The strengths of our scoping review lie in its comprehensive approach to synthesizing diverse... read more

Peripheral and Respiratory Muscle Weakness and Functional Impairments in ICU Patients

This study demonstrated that patients discharged from ICU in this resource-constrained setting presented with peripheral and respiratory muscle weakness at unit discharge. Muscle weakness occurred despite a short ICU... read more

Monitoring Mechanical Ventilation Using Ventilator Waveforms

This book discusses the interpretation of mechanical ventilator waveforms. Each page shows a screenshot from a real patient and explains one or two messages. It starts with basic information about the waveforms and goes... read more

Monitoring Mechanical Ventilation Using Ventilator Waveforms

Nebulized Furosemide Effect on the Mortality of Mechanically Ventilated ARDS Adult Patients

This RCT tackles an important topic in critical care medicine, which involves a large number of critically ill patients and continues to harbor high mortality despite improvements in management. The results of the study... read more

Ventilation Practices in ABI Patients and Association with Outcomes

Current mechanical ventilation practices for patients with acute brain injury (ABI) are poorly defined. This study aimed to describe ventilator settings/parameters used in intensive care units (ICUs) and evaluate their association... read more

Respiratory Monitoring in Mechanical Ventilation: Techniques and Applications

This book covers the up-to-date advancement of respiratory monitoring in ventilation support as well as detecting the physiological responses to therapeutic interventions to avoid complications. Mechanical ventilation nowadays... read more

Respiratory Monitoring in Mechanical Ventilation: Techniques and Applications

Helmet CPAP as NIV for COVID-19 Patients

The COVID-19 pandemic has challenged healthcare systems globally, highlighting the need for effective respiratory support strategies. Helmet continuous positive airway pressure (CPAP) has emerged as a potential noninvasive... read more

Tracheostomy in COVID-19 Patients

Tracheostomy is common in critically ill COVID-19 patients. In patients predicted to need a tracheostomy at some point, early, rather than late, tracheostomy might be a means to reduce the time spent in ICU. However,... read more

Pirfenidone to Prevent Fibrosis in ARDS

Pulmonary fibrosis is a major complication of the Acute Respiratory Distress Syndrome (ARDS). Pirfenidone is an approved treatment for idiopathic pulmonary fibrosis. It may attenuate ARDS-related fibrosis and decrease the... read more

Hemophagocytic Lymphohistiocytosis Markers Associated with Mortality in Critically Ill Patients

The present study highlights the prognostic significance of HLH criteria in critically ill patients. Individuals exhibiting two or more criteria at ICU admission experienced nearly a doubling in mortality as compared to patients... read more

COVID-19 vs non-COVID-19 Patients Without Hematological Malignancies Treated for Invasive Pulmonary Aspergillosis

COVID-19-associated pulmonary aspergillosis (CAPA) patients have less comorbidities and higher fungal burden compared to Putative Invasive Pulmonary Aspergillosis (PIPA), but clinical outcomes are similar between groups.... read more

Airflow Patterns and Adaptive Attachment Ventilation with Deflectors

A novel ventilation mode was introduced and investigated by a series of experiments under isotherm condition, focusing on elucidating the airflow patterns and characteristics associated with this mode. Semi-empirical equations... read more

Oral Health Care and VAP in ICU Patients

Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more

Assessing the Risk of Poor Clinical Outcomes in Preterm Neonates with Late-onset Sepsis

A predictive calculator for assessing the risk of poor clinical outcomes in preterm neonates with late-onset sepsis (LOS) has been developed. By leveraging readily available clinical data at the time of blood culture collection,... read more

Patients Under Mechanical Ventilation Are Highly Perceptive

This meta-synthesis provides insights into the perception of intensive care patients under Mechanical Ventilation (MV) who are continuously observing their own lives. This process is complex and involves a highly differentiated... read more