Tag: mortality
Apoptotic cells for therapeutic use in cytokine storm associated with sepsis
Sepsis has no proven specific pharmacologic treatment. Reported mortality in sepsis ranges from 30%-45%. This study was designed to determine the safety preliminary efficacy of allogenic apoptotic cells administered for immunomodulation... read more
Emerging pharmacological therapies for ARDS: COVID-19 and beyond
ARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biologic mechanisms... read more
Decompensated Hypothyroidism: Why do we miss it, and how do we improve?
A 75-year-old female is brought to the Emergency Department (ED) by emergency medical services (EMS) for altered mental status. Vital signs include BP 87/64, HR 55, T 92.6 rectal, RR 12, SpO2 95% on room air. She is oriented... read more
Prior Routine Use of NSAIDs and Important Outcomes in Hospitalised COVID-19 Patients
Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory... read more
Utility of RV Remodeling Over Risk Stratification in COVID-19
This study contributes to the growing body of literature illustrating the adverse prognostic implications of RV dilation and dysfunction in the setting of severe COVID-19. Mechanistic explanations for RV failure in this population... read more
Conservative or Liberal Oxygen Therapy in Adults After Cardiac Arrest
Conservative oxygen therapy was associated with a statistically significant reduction in mortality at last follow-up compared to liberal oxygen therapy but the certainty of available evidence was low or very low due to bias,... read more
Factors Associated to ICU Mortality in Critically Ill Patients Infected with COVID-19 in Spain
Older COVID-19 patients with higher APACHE II scores on admission, those who developed AKI grades II or III and/or septic shock during ICU stay had an increased risk-of-death. ICU mortality was 31%. A total of 663 patients... read more
Using Dynamic Variables to Guide Perioperative Fluid Management
Intravenous fluid administration is an integral part of patient management during anesthesia. This practice has a strong clinical rationale since a decrease in blood volume, either present before or developing during surgery,... read more
Stress Hyperglycemia and Mortality in Subjects With Diabetes and Sepsis
Stress-induced hyperglycemia is a relevant prognostic factor also in the presence of diabetes. Mild-to-moderate stress hyperglycemia is considered a protective reaction to providing fuel for the immune system and brain at... read more
Early Arterial Embolization and Mortality in Mechanically Ventilated Patients With Hemoptysis
The objective of this study was to clarify whether early intervention by arterial embolization reduced mortality in mechanically ventilated patients with hemoptysis. The results show that early intervention by arterial... read more
Mortality Outcomes with Hydroxychloroquine and Chloroquine in COVID-19
No benefit of hydroxychloroquine or chloroquine on the survival of COVID-19 patients found. For hydroxychloroquine, the confidence interval is compatible with increased mortality or negligibly reduced mortality. Findings... read more
Real-time AI prediction for major adverse cardiac events in emergency department patients with chest pain
An artificial intelligence (AI) real-time prediction model is a promising method for assisting physicians in predicting major adverse cardiac events (MACE) in ED patients with chest pain. Further studies to evaluate the impact... read more
Sepsis and the Obesity Paradox: Size Matters in More Than One Way
Our retrospective analysis suggests that although patient size (i.e., body mass index) is a predictor of in-hospital death among all-comers with sepsis—providing further evidence to the obesity paradox—it adds that illness... read more
Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19
Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority... read more
Steroids Confirmed to Help Severely Ill COVID-19 Patients
In patients hospitalized with COVID-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those... read more
ICU Trends for Patients with COVID-19 in England, Wales and Northern Ireland
Observed trends suggest opposing effects of ICU strain and clinical learning. Further investigation is needed to identify modifiable system factors that could alleviate strain in future epidemics and changes in clinical practice... read more
Pediatric Critical Care and COVID-19
We provide early clinical and laboratory data about critical pediatric COVID-19, which suggest a variable disease but generally good outcomes compared with adults. Targets for research include the course of organ failure... read more
Computer Tomographic Assessment of Gastric Volume in Major Trauma Patients
In major trauma patients, overall stomach volume deriving from food, fluids and air must be expected to be around 400–500 mL. Gastric dilation caused by air is common but not typically associated with pre-hospital airway... read more
